RESUMO
Studies of granular materials, both theoretical and experimental, are often restricted to convex grain shapes. We demonstrate that a nonconvex grain shape can lead to a qualitatively novel macroscopic dynamics. Spatial crosses (hexapods) are continuously sheared in a split-bottom container. Thereby, they develop a secondary flow profile that is completely opposite to that of rod-shaped or lentil-shaped convex grains in the same geometry. The crosses at the surface migrate towards the rotation center and sink there mimicking a "reverse Weissenberg effect." The observed surface flow field suggests the existence of a radial outward flow in the depth of the granular bed, thus, forming a convection cell. This flow field is connected with a dimple formed in the rotation center. The effect is strongly dependent on the particle geometry and the height of the granular bed.
RESUMO
Immune-induced inflammation plays an important role both in aggravating and healing of post myocardial infarction (MI) injuries. Potent anti-inflammatory and local immunomodulatory activity of infliximab has been suggested to have modulating effects on immune responses after MI. The aim of the present study was to evaluate the efficacy of infliximab on hemodynamic responses and myocardial injuries following isoproterenol-induced myocardial infarction. Male Wistar rats, weighting 260 ± 20 g were assigned into ten groups (n = 6) of saline (normal saline), infliximab (7 mg/kg), isoproterenol (100 mg/kg for two consecutive days), and isoproterenol plus infliximab (30 min after the second injection of isoproterenol). The heart tissues and serums were analyzed 24, 48, 72, and 96 h post-MI and hemodynamic parameters, histopathological changes, malondialdehyde (MDA), Total antioxidant capacity (TAC), lactate dehydrogenase (LDH), and lactate levels were assessed in the respective groups. Infliximab partially improved hemodynamic depression in the first days after MI, but the heart became more suppressed later. A similar result also obtained at the MDA tissue levels but not serum levels. Anti-inflammatory effects of Infliximab may improve cardiac function and prevent heart tissue injury early after MI; however, it can worsen the condition later by inhibiting compensatory reactions such as cardiac remodeling and tissue repair.
