RESUMO
A 35-year-old healthy male with no history of any past medical illness developed severe headache, vomiting and drowsiness while at high altitude (4,572 m) in the eastern Himalayan ranges. He was evacuated to a tertiary-care hospital where he was diagnosed to have cerebral sinus venous thrombosis (CSVT) on magnetic resonance imaging, with deep vein thrombosis (DVT) of his right popliteo-femoral vein on color Doppler study. Investigation for thrombophilia revealed protein S (PS) deficiency in this patient. Family screening revealed low levels of PS in two elder brothers. One brother had a history of 'stroke in young' at the age of 20 years with the other being asymptomatic. This established the hereditary nature of PS deficiency. We are not aware of any previously published report on hereditary PS deficiency combined with CSVT and DVT occurring at high altitude. However, 1 case of protein C deficiency with CSVT has been reported previously.
Assuntos
Doença da Altitude/complicações , Deficiência de Proteína S/complicações , Trombose dos Seios Intracranianos/etiologia , Trombofilia/complicações , Tromboflebite/etiologia , Aclimatação , Adulto , Doença da Altitude/sangue , Doença da Altitude/tratamento farmacológico , Anticoagulantes/uso terapêutico , Anticonvulsivantes/uso terapêutico , Infarto Cerebral/diagnóstico por imagem , Infarto Cerebral/etiologia , Saúde da Família , Hemiplegia/tratamento farmacológico , Hemiplegia/etiologia , Humanos , Masculino , Militares , Papiledema/etiologia , Radiografia , Recidiva , Trombose dos Seios Intracranianos/diagnóstico por imagem , Trombose dos Seios Intracranianos/tratamento farmacológico , Trombofilia/genética , Tromboflebite/diagnóstico por imagem , Tromboflebite/tratamento farmacológico , Tromboflebite/genética , Ultrassonografia , Vômito/etiologia , Varfarina/uso terapêuticoRESUMO
A young lady who had aplastic anaemia presented for cerebral venous thrombosis after five years of follow up. She was diagnosed to have paroxysmal nocturnal haemoglobinuria. She had received immunosuppressive therapy with methylprednisolone, cyclosporine-A, anti-lymphocyte globulin, danazol and pregnenolone. The relation between aplastic anaemia, paroxysmal nocturnal haemoglobinuria and cerebral venous thrombosis is discussed. The role of immunosuppressive therapy for aplastic anaemia in causation of paroxysmal nocturnal haemoglobinuria is reviewed.
Assuntos
Anemia Aplástica/complicações , Hemoglobinúria Paroxística/etiologia , Trombose do Seio Sagital/etiologia , Adulto , Anemia Aplástica/induzido quimicamente , Feminino , Humanos , Imunossupressores/efeitos adversos , Imageamento por Ressonância Magnética , Trombose do Seio Sagital/diagnósticoAssuntos
Confusão/etiologia , Intoxicação por Organofosfatos , Adolescente , Atropina/uso terapêutico , Diagnóstico Diferencial , Diarreia/etiologia , Eletromiografia , Eletrofisiologia , Feminino , Humanos , Intoxicação/complicações , Intoxicação/diagnóstico , Intoxicação/terapia , Vômito/etiologiaRESUMO
An Indian female with familial amyloidotic polyneuropathy is reported. The literature with regard to recent advances in the field is reviewed.
Assuntos
Amiloidose/diagnóstico , Doenças do Sistema Nervoso Periférico/genética , Adulto , Amiloidose/genética , Feminino , Humanos , Índia , Doenças do Sistema Nervoso Periférico/diagnósticoRESUMO
Two cases of pancerebellar syndrome following hyperpyrexia are described and the relevant literature reviewed. Cranial computed tomography demonstrated morphologic evidence of cerebellar degeneration while the patients were showing satisfactory clinical progress.
