High-density electric source imaging patterns and outcomes following temporal lobectomy in patients with hippocampal sclerosis.

OBJECTIVE: The objective of this study was to ascertain specific patterns of electrical source imaging (ESI) that are associated with a good surgical outcome (no seizure recurrence) using 256-channel high-density (HD) electroencephalography (EEG) in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) who underwent temporal lobectomy. METHODS: Adult patients (age ≥ 18 years) were prospectively recruited from September 2016 to May 2020 at the authors' center. All patients underwent phase I presurgical evaluation and were subsequently advised to proceed with surgery based on consensus from a multidisciplinary epilepsy conference, without knowing HD-ESI results. All recruited patients were followed for at least 12 months after surgery. The outcome of interest was a status of no seizure recurrence, which was assessed at the end of the study. The association between ESI patterns and outcome was assessed using the chi-square or Fisher exact test. Associated p values as well as odds ratios and 95% CIs were reported. The diagnostic performance of the significant pattern associated with the outcome was also evaluated. RESULTS: Fifty-eight patients with known predictors for either good or worse surgical outcomes were recruited. The mean postoperative follow-up period was 33.34 (SD 13.88) months. Forty-seven patients had sufficient interictal epileptiform discharges for HD-ESI analysis. Thirteen of these 47 patients experienced seizure recurrence. The most common source localizations were at Brodmann area (BA) 20 (inferior temporal area) and BA 21 (middle temporal area). A specific ESI pattern of BA 21 without extratemporal sources was significantly associated with no seizure recurrence (p = 0.047). This pattern had a high positive predictive value of 100% and false-positive rate of 0% associated with no seizure recurrence following the surgery. CONCLUSIONS: A specific ESI pattern that was highly associated with no seizure recurrence following surgery was demonstrated by a 256-channel HD-EEG. If this pattern can be reproducibly proven in further studies, some TLE-HS patients may be able to proceed with surgery without further investigations.

Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.

OBJECTIVE: The objective of the study was to assess the effects of antiepileptic drugs (AEDs) on posterior alpha rhythm and determine whether they produce pathological slow waves in patients with epilepsy. METHODS: Outpatient electroencephalographs (EEGs) in alert patients were selected. The three compared groups include 1) patients with an interested AED (monotherapy or combined with other AEDs); 2) patients with AEDs other than the interested AED; and 3) patients who did not take AEDs. Outcomes were frequency of posterior alpha rhythm and presence of generalized continuous (CSWs) and generalized intermittent slow waves (ISWs). Analysis of variance was used to assess which AED was associated with slower posterior alpha rhythm. Chi-square and logistic regression were employed to assess association and odds ratio (OR) with 95% confidence interval (CI) between pathological generalized slow waves and each AED. RESULTS: Among 1050 EEG tracings, 638 EEGs met our criteria. Electroencephalographs requested because of cognitive decline and psychiatric symptoms were excluded, leaving 616 EEGs for analysis. Four hundred thirty-seven patients received at least one AED, whereas the remaining 179 patients did not take AED. Conventional AEDs [carbamazepine (CBZ), p = 0.024; phenobarbital (PB), p = 0.013; phenytoin (PHT), p = 0.001] except valproic acid (VPA) were associated with slower alpha frequency. Carbamazepine [adjusted OR: 5.74 (95% CI: 2.07, 15.94)] and PB [adjusted OR: 2.58 (95% CI: 1.15, 5.78)] were significantly associated with generalized ISWs. None were associated with generalized CSWs. CONCLUSIONS: Phenytoin, CBZ, and PB are associated with slower posterior alpha frequency. The latter 2 AEDs also produced pathological generalized ISWs. Valproic acid, benzodiazepines, and new-generation AEDs are not associated with either outcome. The presence of generalized ISWs in patients taking CBZ or PB should be cautiously interpreted since there can be drug effects. Association with cognitive side effects of these slow waves should be further studied.