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Metabolomics ; 16(9): 99, 2020 09 11.
Artigo em Inglês | MEDLINE | ID: mdl-32915321

RESUMO

Direct infusion untargeted mass spectrometry-based metabolomics allows for rapid insight into a sample's metabolic activity. However, analysis is often complicated by the large array of detected m/z values and the difficulty to prioritize important m/z and simultaneously annotate their putative identities. To address this challenge, we developed MetaboShiny, a novel R/RShiny-based metabolomics package featuring data analysis, database- and formula-prediction-based annotation and visualization. To demonstrate this, we reproduce and further explore a MetaboLights metabolomics bioinformatics study on lung cancer patient urine samples. MetaboShiny enables rapid and rigorous analysis and interpretation of direct infusion untargeted mass spectrometry-based metabolomics data.


Assuntos
Biologia Computacional , Metabolômica/métodos , Software , Curadoria de Dados , Interpretação Estatística de Dados , Bases de Dados Factuais , Humanos , Neoplasias Pulmonares/metabolismo , Aprendizado de Máquina , Espectrometria de Massas em Tandem
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