Relationship between rehabilitation therapies and outcome of stroke patients in Israel: a preliminary study.

BACKGROUND: The relationship between the amount of rehabilitation therapy and functional outcome in stroke patients has not been established. OBJECTIVES: To evaluate the effectiveness of inpatient rehabilitation for post-acute stroke, and examine the relationship between intensity of therapies and functional status at discharge. METHODS: We evaluated 50 first-stroke patients, average age 63 years, in a prospective descriptive study. The impairment and Functional Independence Measurement were assessed both at admission to rehabilitation and at discharge. Patients were monitored weekly during their stay by means of discipline-specific measures of activity level. Predictor variables included intensity of physical, occupational and speech therapies; demographic characteristics; length of stay; and time since the stroke. RESULTS: A significant reduction in impairment was observed at discharge. The predictors of gains and activity level at discharge as well as motor vs. cognitive components of the FIM were neither consistent nor did they occur in the same trend of functional improvement. Greater FIM motor level at discharge was associated with younger age, higher admission motor and cognitive level, and receipt of any speech therapy, while greater FIM cognitive level was associated with higher cognitive level at admission, shorter interval from onset to admission, and more intense occupational therapy. More intense OT was associated with greater and more cognitive improvement during the hospitalization. CONCLUSION: Since the sample was relatively small and heterogenous in terms of the patients' functional abilities, the findings cannot be generalized to the whole population of stroke patients. Further efforts to identify the best timing, modalities, intensity and frequency of the various treatments are needed to improve the cost-benefit equation of rehabilitation in stroke patients.

Blood homocysteine levels in stroke patients undergoing rehabilitation.

BACKGROUND: One of the major concerns of a stroke victim is the threatening possibility of loosing all the functional achievements attained through prolonged rehabilitation effort, in case of a recurrent cerebrovascular event. Recently, elevated serum homocysteine (Hcy) level was found to be associated with an increased risk for atherosclerotic vascular disease. The aim of the present study was to assess the yield of screening stroke patients for hyperhomocysteinemia, as part of the measures taken to reduce the risk of stroke recurrence. MATERIAL/METHODS: Blood Hcy levels of stroke patients undergoing rehabilitation were compared to the Hcy levels of patients admitted for rehabilitation following brain damage of non-vascular etiologies. RESULTS: The mean Hcy level was found to be significantly higher in the former group (10.21+/-7.81 micromol/L and 6.16+/-4.28 micromol/L in the stroke group and in the non-vascular group, respectively [p<0.003]). However, when analysis of variance was applied and the correlation with age was accounted for, the difference between the groups became insignificant. CONCLUSIONS: Considering the current high cost of blood Hcy tests, the above findings do not support adoption of an overall, non-selective screening policy for hyperhomocysteinemia in stroke patients. However, it may be justified to measure Hcy levels, as well as folic acid, vitamin B6 and vitamin B12 levels, in selected stroke cases. Further study is needed in order to set clear guidelines for the search after this possible risk factor of stroke, one of the major causes of morbidity and mortality in modern society.