[Organic personality disorder: conceptual review and research strategies]. / El trastorno orgánico de la personalidad: análisis conceptual y estrategias para la investigación.

The historical review of "psychiatric personality disorders" reveals the lack of convergence of those disorders with the organic personality disorder (OPD). Only the psychopathy concept has been used as a psychopathological phenotype for one of the groups of OPD, the so-called "pseudopsychopaths". These patients have been described from the beginning of the XXth century under the heading of "frontal lobe syndrome". It was only with the development of the psychiatric nosologies, towards the middle of the XXth century, that the term "organic personality disorder" started to be used. The accumulation of knowledge about the different prefrontal areas and the development of neuropsychological models that try to explain social behavior have opened new ways of understanding this syndrome. The orbitofrontal cortex has been identified as one of the key structures in behavioral and emotional regulation. Recognition of emotions in voices and faces, empathy, appreciation of humor, tasks that show "theory of mind" are some of the dimensions included in the examination of the non-cognitive functions of the prefrontal cortex

[Attentional impairment after traumatic brain injury: assessment and rehabilitation]. / Alteraciones de la atención tras daño cerebral traumático: evaluación y rehabilitación.

INTRODUCTION: Attention disorders are a major problem after traumatic brain injury underlying deficits in other cognitive functions and in everyday activities, hindering the rehabilitation process and the possibility of return to work. Functional neuroimaging and neuropsychological assessment have depicted theoretical models considering attention as a complex and non-unitary process. DEVELOPMENT: Although there are conceptual difficulties, it seems possible to establish a theoretical background to better define attentional impairments and to guide the rehabilitation process. The aim of the present study is to review some of the most important pieces involved in the assessment and rehabilitation of attentional impairments. We also propose an appropriate model for the design of individualized rehabilitation programs. Lastly, different approaches for the rehabilitation are reviewed. CONCLUSIONS: Neuropsychological assessment should provide valuable strategies to better design the cognitive rehabilitation programs. It is necessary to establish a link between basic and applied neuropsychology, in order to optimize the treatments for traumatic brain injury patients. It is also emphasized that well-defined cognitive targets and skills are required, given that an unspecific stimulation of cognitive processes (pseudorehabilitation) has been shown to be unsuccessful.

[Memory and the executive functions]. / Memoria y funciones ejecutivas.

INTRODUCTION: The terms 'executive functioning' or 'executive control' refer to a set of mechanisms involved in the improvement of cognitive processes to guide them towards the resolution of complex problems. Both the frontal lobes, acting as structure, and the executive processes, acting as function, work with memory contents, operating with information placed in the diencephalic structures and in the medial temporal lobe. Generally, we can state that many works find an association between frontal damage and specific memory shortages like working memory deficit, metamemory problems, source amnesia, or difficulties in the prospective memory. DEVELOPMENT: This paper is a critical review of the working memory concept and proposes a new term: the attentional operative system that works with memory contents. Concerning the metamemory, the frontal lobes are essential for monitoring processes in general and for 'the feeling of knowing' kind of judgements in particular. CONCLUSIONS: Patients suffering prefrontal damage show serious problems to remember the information source. Thus, the information is rightly remembered but the spatiotemporal context where that information was learned has been forgotten. Finally, the prospective memory deals with remembering to make something in a particular moment in the future and performing the plan previously drawn up.

[A proposal for a protocol for use in the evaluation of the executive functions]. / Propuesta de un protocolo para la evaluación de las funciones ejecutivas.

INTRODUCTION: Executive functions include a variety of components such as the capacity implicated in goal formulation, the faculties employed in processes planning, and the strategies used to achieve the pretended objectives. In a previous work, taking as starting basis those models which have attempted to clarify those processes implicated in executive functions, we posed an integrative model. DEVELOPMENT: Starting from this model, we now propose an assessment protocol. Thus, executive functions considered as problem solving, require in generic terms, objective selection, planning, and monitoring processes (tower of Hanoi and zoo map). Each of these sub-processes operate through the working memory both with the visospatial sketch and the phonological loop. The central executive system, or attentional supervisor system (ASS), acts when there is no known solution and we must create an alternative one. CONCLUSIONS: In this sense, the ASS could contain the following functions: amplification of the phonological loop and visospatial sketch capacity (Sternberg type tasks), information manipulation and actualization (n-back paradigm), information manipulation and maintenance (Wechsler Memory Scale letters and numbers), simultaneously work in two cognitive tasks (dual execution tasks), inhibition (Stroop and go-no go paradigms), and cognitive sets alternation (Wisconsin Card Sorting Test). Once this planning process has been done, we must take a decision (gambling task paradigm), being the somatic marker in charge of this process.

[Pragmatic impairments following traumatic brain injury]. / Alteraciones de la pragmática de la comunicación después de un traumatismo craneoencefálico.

OBJECTIVE: To describe how cognitive impairments contribute to the loss of communicative competence after traumatic brain injury (TBI), what instruments can be used to evaluate the pragmatic skills and which therapeutic approaches may be used to improve or compensate for this deficit. DISCUSSION: We present a detailed bibliographic review on the topic that shows how certain functions (namely, memory, attention and executive functions) interact with communication skills, both expressive and comprehensive. The pragmatic approaches for cognitive-communicative TBI impairments are allow to count typical difficulties that are described (difficulty with topic selection, turn-taking initiation, ability to respond or give indirect requests, ability to meet the informational needs of the listener, appropriateness of utterances within conversation, etc). Next a general outline of the assessment and treatment of is provided, including several strategies based on recovery and functional adaptation and compensation. CONCLUSIONS: Given the huge influence of communicative skills on social and vocational integration, it is crucial to obtain a better understanding of the interaction between cognitive functions and communicative skills. Therefore, we need to devise assessment protocols specifically designed for Spanish speakers as well as new therapeutic approaches to increase the life quality of this population. The specific approaches to improve narrative, procedural and conversational discourse must divide from the components of the pragmatic competence and promote the cooperative participation of the teamwork who attend to the patient.

[Rehabilitation programs for executive functions]. / Rehabilitacion de las funciones ejecutivas.

INTRODUCTION: The executive functions are the high-level functions that have generated many studies. These functions comprise a whole range of cognitive abilities related to novelty problem solving. So, it includes: goal selection, planning, initiation of activity, self regulation and use of feedback. There are many papers about the definition of executive functions and about their deficits in different pathologies. However, there only exist a few works about the possibility of recovering these functions and the elaboration of programs of cognitive rehabilitation. AIM AND METHOD: The aim of this report is to review the main rehabilitation programs for executive functions and to adapt them to our culture and context from a theoretical practice perspective. In spite of the utility of these programs, we make a reflection on their limitations. In this sense, we emphasized the oversight of emotional aspects involved in decision making. Besides, new directions for the investigation in this area are pointed out.

[Functional neuroimaging applied to the study of neuropsychological rehabilitation]. / Aplicación de la neuroimagen funcional al estudio de la rehabilitación neuropsicológica.

OBJECTIVE: We review the main aspects of functional recovery after brain injury as well as neuroimaging characteristics that make it relevant and useful to assess these changes. We also review some issues regarding recovery of motor and sensory functions, language and visuo spatial processes, and we discuss the methods used in this field, the difficulties found, and future implications. DEVELOPMENT: One of the main aspects in the study of the brain is the capacity to reorganize different functions in order to compensate for the deficits after a lesion in the central nervous system. The study of these adaptive processes is important in a clinical field as well as for basic research, as it is a clear example of brain plasticity. All the findings show how the study of the plastic phenomena or functional reorganization will allow us to better know how the brain works after a lesion. CONCLUSION: The use and combination of the new functional neuroimaging techniques gives the opportunity to register the reorganization of the brain with a high temporal and spatial resolution. It will give also an objective measure to assess the effectiveness of the rehabilitation programs. It will allow to identify different variables related to rehabilitation outcome and will guide effectively the selection of different rehabilitation approaches.

[Attention and executive processes in neuropsychological rehabilitation of the visuospatial processes]. / Atencion y funcionamiento ejecutivo en la rehabilitacion neuropsicologica de los procesos visuoespaciales.

INTRODUCTION AND OBJECTIVE: Cognitive deficits following lesions in parieto occipital areas tend to cause, among others, visuospatial and visuoperceptive alterations. The aim of this article is to examine the influence of others possible deficit over its rehabilitation. DEVELOPMENT: We discuss several patients who present visuospatial impairment after different brain injuries, not only those affecting the areas typically involved in these deficits, such as parieto occipital cortex. Rehabilitation was conducted on an individual basis in the brain injury unit of Beata Maria Ana hospital. Neuropsychological evaluation showed some difficulties not previously described together with these deficits, related to attention, working memory and executive functions, as well as topographic disorientation, lack of visuospatial coordination, distances perception disorders and difficulty to mentally rotate objects. The rehabilitation was AIMed not only at restoration but also compensation of visuospatial deficits, successfully achieved after treatment: patients were capable of returning to their daily activities, including their jobs. CONCLUSION: In patients with visuospatial deficits, a compressive neuropsychological evaluation seem to be essential to define the influence of the other cognitive domains over the rehabilitation of visuospatial problems. In particular, the reinforcement of processes related to attention control and executive functions could very important, give their contribution to the learning of compensatory strategies and assuming that those functions pay key role in the organization and supervision demanded for perceptual skills.

[Psychiatric and neuropsychological legal assessment of traumatic brain damage and Law 30/95]. / La peritación psiquiátrica y neuropsicológica del daño cerebral traumático y la Ley 30/95.

Medico-legal assessment of people who have suffered injuries in road traffic accidents must use Law 30/95 as a reference frame. Psychiatric and neuropsychological syndromes secondary to traumatic brain injury (TBI) are no exception and pose demanding challenges to physicians and psychologists. This paper analyzes descriptive and nosological difficulties face by psychiatrists and psychologists; their expert contribution includes translation of official diagnostic entities into categories published in the annex of Law 30/95. Our psychopathological repertoire was created in the 19th century and has hardly been revised since. The wide and varied types of neuropsychological impairments encountered in TBI have to be diagnosed within a very narrow range of DSM-IV and ICD-10 categories. The most common conflicts encountered in the medicolegal arena are revised: the differential diagnosis between dementia and combinations of organic personality disorder with cognitive impairment; differential diagnosis between spontaneous psychiatric illness (bipolar disorder, schizophrenia) and psychiatric syndromes secondary to brain injury (posttraumatic psychosis, organic bipolar disorder); differential diagnosis between concussional syndrome and organic personality disorder, cognitive impairment or organic affective disorder. Specific diagnostic guidelines are suggested for each of these clinical situations. Actas Esp Psiquiatr 2003;31(6):353-360

[Towards a taxonomy of consciousness]. / Hacia una taxonomía de la conciencia.

INTRODUCTION: There are many definitions in order to describe the consciousness. In the literature appear concepts such alertness, attention, knowledge, conscious experience, awareness of deficits, self awareness, theory of mind in relation with consciousness definition. This multiplicity conceptual lead to formulate a question: Do exist different levels of complexity in the consciousness that depend on neuroanatomics structures differentiated? METHOD: In this paper an approximation toward a taxonomy of consciousness is offered and five levels of complexity and its relation with cerebral structures differentiated are suggested. In the first place, it s consider the alertness state as a necessary condition to exist the consciousness and his relation with attentional states. In the second place, it s present the conscious experience that depends on synchronicity neural activity. On the other hand, the daily clinic work shows the possibility of the existence of a consciousness for each specific field of knowledge. In the fourth place, it s located the self awareness understood like the capacity to perceive to us with objectivity but maintaining a subjectivity sense. At last, the theory of mind refers to the ability for attribute to the others specific mental states. CONCLUSION: It s plan an analysis of the different models that have tried to give an answer to each one of complexity levels to attempt an approach based on the analytic science and not descriptive plane.

[Executive functions: the need for the integration of concepts]. / Funciones ejecutivas: necesidad de una integración conceptual.

INTRODUCTION: The new cognitive neuropsychology approaches have aroused an increasing interest in understanding the higher cognitive processes as well as the neural substrates linked to them. Particularly, the executive functions, reckoned to be essential to control the information processing and to co ordinate behaviour, have received preferential treatment from specialised literature on the subject. DEVELOPMENT: From obsessive compulsive disorder to schizophrenia, from Parkinson s disease to multiple sclerosis, there are many reports that show the affectation of these functions in all these morbid processes. On the other hand, the part that the prefrontal cortex plays in human behaviour in general, and in executive functions in particular, constitutes one of the most important fields of research of neurosciences nowadays. Thus, this cortical area appears closely linked to the executive processes, affecting different respects of the cognitive functions. Working memory, supervisory attentional system, somatic marker, information processing, behaviour planning, social judgement, are processes which have been related to the prefrontal cortex activity as a structure, and to the executive processes as a function. CONCLUSIONS: The aim of this article is to revise the concept of executive functions, and give rise reflections about the usefulness of the aforementioned concept and its practical applicability. It is essential that we understand the difference between structure and function, cognition and emotion, brain activity and behaviour, category and dimension, and between mind and brain, to achieve a more comprehensive approach to this concept of executive functions we all use, and many times find difficult to define and to understand.

[Nosologic aspects of personality change due to head trauma]. / Consideraciones nosológicas del cambio de personalidad postraumático.

INTRODUCTION: Personality change due to head injury is one of the most prevalent neuropsychiatric posttraumatic disorders and causes significant impairment in familial, social or occupational functioning. OBJECTIVES: To study the prevalence and clinical characteristics of personality changes secondary to severe closed head injuries, according to DSM-IV criteria. PATIENTS AND METHODS: Fifty-five patients (aged 15-65 years) with severe head trauma were studied during the chronic stage (11-3 months) with the following instruments: the Revised Iowa Collateral Head Injury Interview for the assessment of posttraumatic frontal symptoms, the Standardized Polyvalent Psychiatric Interview of Lobo et al, assessment of premorbid personality and its exacerbation, and the Scale of Aggressiveness of Yudofsky. RESULTS: Thirty-three patients (60% of the sample) fulfilled DSM-IV criteria for personality change due to head injury; two thirds of them were combined or mixed type, which consists in the association of two or more types specified in the DSM-IV. The most prevalent types were apathic, unstable, disinhibited, aggressive, which are related with lesions in prefrontal cortex. There were nine patients with 'unspecified' symptoms, such as 'inappropriate euphoria' and 'poor insight', and other symptoms related to executive dysfunction. CONCLUSIONS: One third of cases of personality changes were related to premorbid features; this fact argues against the exclusion of the criterium 'excerbation of premorbid personality traits' in DSM-IV. Only one third of posttraumatic personality changes can be classified according to DSM-IV and ICD-10 criteria. The high prevalence of symptoms related to deficit in self-awareness and executive dysfunction suggest the need of further investigations about nosology in this field.

[The detection of possible cases of simulation after a traumatic brain injury]. / La detección de los posibles casos de simulación después de un traumatismo craneoencefálico.

OBJECTIVE: To show the degree of detection of simulation, defined as the conscious, intentional production of false or exaggerated physical and psychological symptoms, motivated by external rewards such as payments by insurance companies and compensations. DEVELOPMENT: In forensic circles, a major problem is under consideration, namely recognition of the existence and nature of cognitive alterations after mild head injury (HI), since it is estimated that in 5-10% of the cases of mild HI there may be simulation of cognitive and emotional deficit, with further difficulty of differential diagnosis between simulation and the post-concussion syndrome. CONCLUSIONS: The forensic assessment of cognitive alterations following HI should include a clinical interview and neuropsychological evaluation. The former helps to determine the causal relationship between the traumatic accident and the resulting damage, continuance of symptoms and the existence or not of a premorbid pathological state. Although there is still not completely reliable, valid marker which permits one to be completely certain that the person is a simulator, neuropsychological evaluation permits suspicion of it in three aspects: 1. General indicators showing lack of internal consistence in the results of the person evaluated. 2. Specific tests to detect possible cases of simulation. 3. Profiles of responses which characterize possible simulators and neuropsychological evaluation tests.

[Differential diagnosis of post-concussive syndrome]. / Diagnóstico diferencial del síndrome posconmocional.

INTRODUCTION: Posconcussional syndrome is characterized by a heterogeneous group of somatic, cognitive and psychosocial symptoms, which occur in patients with head trauma, generally of mild severity. It is the neuropsychiatric postraumatic disorder more prevalent in the field of forensic medicine. DEVELOPMENT: Classical authors (Lishamn and Barraquer, for example) focused on controversial aspects of this syndrome, such as conceptual problems and etiology (organic versus functional). The objective of this report is to review the posconcussional literature in search of relevant aspects in forensic neuropsychology: conceptual aspects, epidemiology, etiology, clinical features, methodology for assessment, and its differential diagnosis with other postraumatic disorders, such as postraumatic stress disorder, adjustment disorder, anxiety disorder, mood disorders (major depressive disorder), substancerelated disorders, dementia due to head trauma, amnesic disorder, somatoform disorders, factitious disorder, malingering, chronic pain and chronic whiplash syndrome.

[Prognostic factors in head injuries]. / Factores de pronóstico en los traumatismos craneoencefálicos.

INTRODUCTION AND OBJECTIVE: Establishment of the prognosis after traumatic brain damage is an important question for doctors, patients and their families, as well as for health organizations and insurers. The precision of the prognosis varies markedly according to the final objective of the prediction (mortality, severity and type of residual defects, return to work), apart from consideration of the many factors which may affect the clinical course after this type of lesion. Our study considers the current state of this question. DEVELOPMENT: We consider the main methodological difficulties in carrying out such studies and review the main variables affecting the prognosis in head injuries, divided into three general groups (severity and type of lesion, characteristics of the individual and variables depending on the context). Finally, we make general comments on the effect of multidisciplinary rehabilitation in relation to the functional prognosis and level of social and employment integration attained by the injured persons.

[Training in social skills in patients with acquired brain damage]. / Entrenamiento en habilidades sociales en pacientes con daño cerebral adquirido.

INTRODUCTION: Brain damaged patients have cognitive deficits, behaviour disorders and personality changes which affect socio-familial behaviour. Frequently, these changes generate considerable disturbance between family members and make it very difficult to return to work. OBJECTIVE: We describe a pilot study which led to the development and application of a focal rehabilitation programme aimed at retraining this group in social skills. PATIENTS AND METHODS: The programme was intensive (3 months) and included 6 outpatients (5 men and 1 woman) who took part in programmes of neuropsychological rehabilitation after traumatic or vascular cerebral lesions (X = 19.2 months after the lesion occurred). The average age of the patients was 27.2 years and their average IQ 109.2. Individual and group interventions were combined (role-playing, 'make-believe' work, video filming) emphasizing particularly the processes of learning without making mistakes and the extension of achievements to the natural setting (controlled trials). RESULTS AND CONCLUSIONS: We state and describe the relationship between the nature of neuropsychological and psychopathological deficits, and the characteristics of the limitations in social behaviour. The patients showed a significant reduction in the level of anxiety and aggressive behaviour and improvement in consciousness of their defects. Some improvement was seen in expressing opinions and emotions, and in ability to adapt social conduct to different situations (flexible behaviour). Finally we describe the conclusions drawn as to this treatment for future review and improvement of the programme.

Attentional set shifting modulates the target P3b response in the Wisconsin card sorting test.

For years the Wisconsin card sorting test (WCST) has been used as a test of frontal lobe function. Recent event-related potential (ERP) research has shown large differences in the amplitude of P3b responses evoked by early and late trials within each WCST series ([8]: Barceló F., Sanz M., Molina V., Rubia FJ. The Wisconsin Card Sorting Test and the assessment of frontal function: A validation study with event-related potentials. Neuropsychologia 1997;35:399-408). In this study, 16 normal subjects performed a WCST adaptation to investigate the role of attentional set shifting in these WCST P3b effects. Two control tasks were designed to examine whether early-late WCST P3b changes reflect category selection (attention) or category storage (memory) operations. Results suggest both a sharp P3b attenuation during shift WCST trials, followed by a gradual P3b build-up during post-shift trials. This P3b modulation could not be attributed to selection or storage of simple sensory stimulus dimensions, nor was it observed when the new rule was externally prompted by the first card in the WCST series. Instead, WCST P3b changes seem related to the endogenously generated shift in the perceptual rule used to sort the cards (i.e., the shift in set). The gradual build-up in P3b amplitude paralleled a progressive improvement in sorting efficiency over several post-shift WCST trials. A model based on formal theories of visual attention and attentional set shifting is proposed to account for these effects. The model offers firm grounds for prediction and bridges the gap between related clinical and experimental evidence.

[The nature, diagnosis and treatment of post-concussion syndrome]. / Sobre la naturaleza, diagnóstico y tratamiento del síndrome posconmocional.

INTRODUCTION: The relationship between brief loss of consciousness, subsequent cognitive and emotional complaints, and impact on daily functioning continues to be hotly debated. DEVELOPMENT: In this paper the strong variability about prevalence of the postconcussional syndrome found in several studies is outstanding and the main issues of this disagreement are suggested. Recent neuroimaging techniques are discussed and some neuropsychological measures are suggested. CONCLUSIONS: Currents models (organic/psychogenic) of postconcussional symptoms are reviewed, and a multifactorial model which integrates biological factors with the relevance of neuropsychological deficits--attention, memory, speed of information processing--and coping process is proposed. Finally, according with this model, we conclude with some suggestions to improve neuropsychological intervention and medical treatment of these patients.