RESUMO
Sex differences in the morphogenesis and adaptation of the mechanisms controlling myocardium contractility during physiological and pathological hypertrophy of the right ventricle were demonstrated in mature rats. The study revealed sex-dependent effects of physiological and pathological cardiac hypertrophy on the coefficient of variation of the cardiomyocyte diameter, length-dependent control of the contractile force, and the maximum velocity of isotonic shortening.
Assuntos
Coração/fisiologia , Contração Isométrica/fisiologia , Contração Isotônica/fisiologia , Contração Miocárdica/fisiologia , Miócitos Cardíacos/fisiologia , Animais , Cardiomegalia/induzido quimicamente , Cardiomegalia/fisiopatologia , Tamanho Celular , Feminino , Coração/efeitos dos fármacos , Coração/fisiopatologia , Ventrículos do Coração/efeitos dos fármacos , Ventrículos do Coração/fisiopatologia , Contração Isométrica/efeitos dos fármacos , Contração Isotônica/efeitos dos fármacos , Masculino , Monocrotalina/toxicidade , Contração Miocárdica/efeitos dos fármacos , Miócitos Cardíacos/efeitos dos fármacos , Miócitos Cardíacos/patologia , Ratos , Ratos Wistar , Caracteres Sexuais , NataçãoRESUMO
The comprehensive study of morphometrical parameters and viscoelastic properties of right ventricle and left ventricle papillary muscles of ISIAH rats during the development of arterial hypertension has been carried out. It is established the significant increase of the index of heart mass to body mass and to tibia length of ISIAH rats in comparison with WAG rats of the same age. There are no any significant differences of "stress-strain" dependences of all experimental groups.
Assuntos
Hipertensão/fisiopatologia , Hipertrofia Ventricular Esquerda/fisiopatologia , Hipertrofia Ventricular Direita/fisiopatologia , Músculos Papilares/fisiopatologia , Animais , Pressão Sanguínea , Humanos , Rim/fisiopatologia , Ratos , Estresse FisiológicoRESUMO
A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6h a day. Parameters of the morphological and functional states of the organs studied were measured and biochemical and enzyme-immunoassays were carried out on the first and second days. This study reveals that the main mechanism by which the L17 compound mediates of its anti-stress was by activation of macrophages on the second day of the experiments and the inhibition of apoptosis in the thymus. The results enable us to suggest that the compound L17 does not improve resistance to stress; however, it does lower the reaction to stress.
Assuntos
Fatores Imunológicos/farmacologia , Estresse Fisiológico/imunologia , Tiadiazinas/farmacologia , Glândulas Suprarrenais/efeitos dos fármacos , Glândulas Suprarrenais/patologia , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Glicemia/análise , Corticosterona/sangue , Masculino , Pâncreas/efeitos dos fármacos , Pâncreas/patologia , Ratos , Restrição Física , Baço/efeitos dos fármacos , Baço/patologia , Estresse Fisiológico/efeitos dos fármacos , Timo/efeitos dos fármacos , Timo/patologiaRESUMO
Response of mast cells to stress has a systemic character, being observed in organs both determining development of stress reaction (thymus, bone marrow, adrenals, stomach, duodenum) and not participating in this process (skin, liver). The reaction of mastocytes is manifested as a total degranulation. Mast cell secretion is regulatory by its nature, and biologically active compound are released directly on the target cells. Along with degranulation, which is observed in organs participating in stress reaction formation, migration of mast cells takes place, resulting in their redistribution.