Recent advances in respiratory diseases: Dietary carotenoids as choice of therapeutics.

A group of bioactive, isoprenoid pigments known as carotenoids is mostly present in fruits and vegetables. Carotenoids are essential for the prevention of physiological issues, which makes maintaining excellent health easier. They are effective functional ingredients with potent health-promoting properties that are widely present in our food and linked to a decrease in the prevalence of chronic diseases, including respiratory diseases. Respiratory infections are the primary cause of death and life-threatening conditions globally, wreaking havoc on the global health system. People rely on dietary sources of carotenoids to reduce a plethora of respiratory diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, asthma, and so on. Carotenoids have received a lot of interest recently in several parts of the world due to their therapeutic potential in altering the pathogenic pathways underlying inflammatory respiratory diseases, which may improve disease control and have beneficial health benefits. This review aimed to provide a thorough understanding of the therapeutic potential of dietary carotenoids in the treatment of respiratory diseases and to identify possible candidates for novel therapeutic development.

Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential.

Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ homeostasis modulation, and osmotic regulation. Regardless of this, analogues of tacrine are considered as a model inhibitor of cholinesterase in the therapy of Alzheimer's disease. The variety both in structural make-up and biological functions of these substances is the main appeal for researchers' interest in them. A new paradigm for treating neurological diseases is presented in this review, which includes treatment strategies for Alzheimer's disease, as well as other neurological disorders like Parkinson's disease and the synthesis and biological properties of newly identified versatile tacrine analogues and hybrids. We have also shown that these analogues may have therapeutic promise in the treatment of neurological diseases in a variety of experimental systems.

Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action.

Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants, molds, and lichens. Emodin has been used as a traditional medication for more than 2000 years and is still common in numerous herbal drugs. Emodin is plentiful in the three plant families, including Polygonaceae (Rheum, Rumex, and Polygonum spp.), Fabaceae (Cassia spp.), and Rhamnaceae (Rhamnus, Frangula, and Ventilago spp.). Emerging experimental evidences indicate that emodin confers a wide range of pharmacological activities; special focus was implemented toward neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, anxiety and depression, schizophrenia, chronic hyperglycemic peripheral neuropathy, etc. Numerous preclinical evidences were established in support of the neuroprotection of emodin. However, this review highlighted the role of emodin as a potent neurotherapeutic agent; therefore, its evidence-based functionality on neurological disorders (NDs).

Evaluation of sleep quality, psychological states and subsequent self-medication practice among the Bangladeshi population during Covid-19 pandemic.

INTRODUCTION: Due to the extended lockdown imposed for SARS-CoV-2 pandemic, many people have experienced problematic sleep patterns and associated health issues worldwide. This study was conducted to assess the sleep quality and psychological states of the Bangladeshi population during the COVID-19 pandemic, respondent's behavioral traits as well as psychological or sleep-related problems induced self-medication practice among the respondents, along with the probability of development of drug dependency. METHODS: The survey was conducted among 2941 respondents from 25th November 2020 to 4th December 2020 where the responses were analyzed by SPSS V22. RESULTS: 10-29.5% experienced a significant degree of sleep problems whereas some experienced severe anxiety and depression. The associations between the behavioral traits and parameters concerning sleep quality, anxiety and depression showed 5% level of significance in all cases. Self-medication practice of sleep aids during this pandemic was reported by 7.14% of the respondents, with a greater percentage belonging to the female or senior age group. Tendency to repeatedly self-medication was observed in 18.86% of this self-medicating populace, and a greater number of male (10.26%) respondents displayed such tendency as opposed to their female (8.6%) equivalents. However, 48.10% of the respondents reported perceptions of improved physical and/or psychological health following self-medication, and this trait was predominant in men (52.14%). CONCLUSION: Results showed a significant number of Bangladeshi populaces were suffering from psychological issues during this COVID-19 which also influenced a certain number of people towards self-medication practice where signs of drug dependency were observed in a significant number of respondents.