Sediment grain size and benthic community structure in the eastern English Channel: Species-dependent responses and environmental influence.

This study addresses the scarcity of evidence on the relationship between benthic communities and coarse-grained sediments in the eastern English Channel. The region's geological history contributes to its predominantly coarse sediment composition. The study employs ternary plots to visualize benthic species' preferences and tolerance for sediment types, revealing their effectiveness. Redundancy Analyses (RDA) and species-level quantile regressions explore the influence of grain size on benthic species distribution. The results indicate a moderate impact of grain size, influenced by hydrodynamics. Estuaries, particularly the Seine Estuary, significantly shape benthic species distribution. Quantile regressions underscore the varied responses of benthic communities along the grain size gradient. The study underscores the importance of considering coarse sediments, offering insights into the complex relationship between benthic communities and sediment characteristics.

Unlikely lead-bearing phases in river and estuary sediments near an ancient mine (Huelgoat, Brittany, France).

Anthropocene mineral diversity is the result of the purification of metals naturally combined with other chemical elements in natural environment. Moreover, the advent of human mining and manufacturing mineral-like compounds has experienced a punctuation event in diversity and distribution owing to the pervasive impact of human activities. In this context, the wastes of an abandoned historical mine, Huelgoat mine (Brittany, France), famous during the eighteenth and the nineteenth century contain significant amounts of chemical elements potentially dangerous to the environment. Lead concentration and Pb-bearing phases were quantified in 7 sediments samples located from mine upstream to the Aulne estuary (100 km downstream to the mine). Results show very high concentrations of lead in the stations located upstream and downstream of the Huelgoat mine, using X-ray fluorescence spectroscopy, ranging from 7000 mg/kg downstream of the mine to a natural concentration of about 80 mg/kg upstream. At the same time, Pb-bearing phases were identified depending on the particle sizes, fine (< 50 µm) and coarse (> 50 µm), using X-ray powder diffraction (XRD), scanning electron microscopy (SEM), total organic carbon (TOC), and pH analyses. For the first time, evidence of anthropogenic mineral "iodoplumbate" formation has been described in a natural environment.

ED-XRF: a promising method for accurate and rapid quantification of metals in a bacterial matrix.

ABSTRACTThe remediation of metal-polluted water using bacterial biofilms is a promising technology. In order to help its development, the present study aims to evaluate the feasibility to utilize XRF spectrometry for accurate and rapid measurement of metal concentrations in bacterial biofilms used in treatment plants. For that purpose, an ED-XRF spectrometer was used to measure Cd, Cu, Fe, Mn, Ni and Zn concentrations within a matrix of marine bacteria Pseudomonas fluorescens BA3SM1 and its metabolites. Contaminated and control cultures of the strain BA3SM1 were dried and crushed, then analysed by ED-XRF. The LOD value of the analysed metals was between 2.08 and 10.5 µg g-1. Metal concentrations were also measured by ICP-AES or ICP-MS to support ED-XRF results. The two techniques showed a good linear correlation with a slope of at least 0.949 and R2 of at least 0.985. These results confirm the possibility to measure metal contents by ED-XRF in bacterial matrices.

Ozanimod to Treat Relapsing Forms of Multiple Sclerosis: A Comprehensive Review of Disease, Drug Efficacy and Side Effects.

Multiple sclerosis (MS) is a prevalent and debilitating neurologic condition characterized by widespread neurodegeneration and the formation of focal demyelinating plaques in the central nervous system. Current therapeutic options are complex and attempt to manage acute relapse, modify disease, and manage symptoms. Such therapies often prove insufficient alone and highlight the need for more targeted MS treatments with reduced systemic side effect profiles. Ozanimod is a novel S1P (sphingosine-1-phosphate) receptor modulator used for the treatment of clinically isolated syndrome, relapsing-remitting, and secondary progressive forms of multiple sclerosis. It selectively modulates S1P1 and S1P5 receptors to prevent autoreactive lymphocytes from entering the CNS where they can promote nerve damage and inflammation. Ozanimod was approved by the US Food and Drug Administration (US FDA) for the management of multiple sclerosis in March 2020 and has been proved to be both effective and well tolerated. Of note, ozanimod is associated with the following complications: increased risk of infections, liver injury, fetal risk, increased blood pressure, respiratory effects, macular edema, and posterior reversible encephalopathy syndrome, among others. Further investigation including head-to-head clinical trials is warranted to evaluate the efficacy of ozanimod compared with other S1P1 receptor modulators.

Marine aggregates in North Atlantic coast: Microbial characteristics and potential interactions with farmed Atlantic salmon (Salmo salar).

Microbial contamination of aggregates collected near an Atlantic salmon farm, in the Cherbourg roadstead, was followed monthly over one year to study the dynamics of Vibrio spp. and explore their impact on farmed fish. Salmon state of health was followed through blood and histopathological analyses. Vibrio were systematically found in aggregates with particularly high concentration in August. The Splendidus clade was strongly dominant in aggregates as well as in gills, and an increase in Vibrio diversity was observed in summer and autumn. Results did not demonstrate that aggregates directly impact the bacterial community of gills, but they suggested an aggregates-gills interaction. Gill contamination was correlated with water temperature and probably impacted by amoebae. Vibrio renipiscarius and Vibrio toranzoniae were isolated in North Atlantic for the first time. A better understanding of the interaction between marine aggregates, Vibrio spp. and fish is essential to improve salmon cage farming.

Improving the monitoring of a dumping site in a dynamic environment. Example of the Octeville site (Bay of Seine, English Channel).

Dredged sediments have different physical and chemical characteristics compared with the sediments in place, which generates multiple effects on the environment. In this study, we show that the sampling strategy used to monitor the effects of dredge spoil deposition on the surrounding environment can lead to different interpretations. It appears that sediment sample replicates may or may not be necessary, depending on the studied area, the prevailing environmental forcings before sediment sampling and the combination of these two factors. The proposed modus operandi allows us to optimize both the confidence on the obtained results and the cost of the sediment studies (sampling and laboratory analyses). The results are based on the sediment fine fraction, which is considered as a key environmental component due, for example, to its strong association with the structure of benthic faunal communities as well as its role in the build-up of pollutants.

Sampling epifauna, a necessity for a better assessment of benthic ecosystem functioning: an example of the epibenthic aggregated species Ophiothrix fragilis from the Bay of Seine.

Sampling the sea bottom surface remains difficult because of the surface hydraulic shock due to water flowing through the gear (i.e., the bow wave effect) and the loss of epifauna organisms due to the gear's closing mechanism. Slow-moving mobile epifauna, such as the ophiuroid Ophiothrix fragilis, form high-density patches in the English Channel, not only on pebbles like in the Dover Strait or offshore Brittany but also on gravel in the Bay of Seine (>5000 ind m(-2)). Such populations form high biomasses and control the water transfer from the water column to the sediment. Estimating their real density and biomass is essential for the assessment of benthic ecosystem functioning using trophic web modelling. In this paper, we present and discuss the patch patterns and sampling efficiency of the different methods for collecting in the dense beds of O. fragilis in the Bay of Seine. The large Hamon grab (0.25 m(-2)) highly under-estimated the ophiuroid density, while the Smith McIntyre appeared adequate among the tested sampling grabs. Nowadays, diving sampling, underwater photography and videos with remote operated vehicle appear to be the recommended alternatives to estimate the real density of such dense slow-moving mobile epifauna.