Association between socioeconomic deprivation and bone health status in the UK biobank cohort participants.

The effect of deprivation on total bone health status has not been well defined. We examined the relationship between socioeconomic deprivation and poor bone health and falls and we found a significant association. The finding could be beneficial for current public health strategies to minimise disparities in bone health. PURPOSE: Socioeconomic deprivation is associated with many illnesses including increased fracture incidence in older people. However, the effect of deprivation on total bone health status has not been well defined. To examine the relationship between socioeconomic deprivation and poor bone health and falls, we conducted a cross-sectional study using baseline measures from the United Kingdom (UK) Biobank cohort comprising 502,682 participants aged 40-69 years at recruitment during 2006-2010. METHOD: We examined four outcomes: 1) low bone mineral density/osteopenia, 2) fall in last year, 3) fracture in the last five years, and 4) fracture from a simple fall in the last five years. To measure socioeconomic deprivation, we used the Townsend index of the participant's residential postcode. RESULTS: At baseline, 29% of participants had low bone density (T-score of heel < -1 standard deviation), 20% reported a fall in the previous year, and 10% reported a fracture in the previous five years. Among participants experiencing a fracture, 60% reported the cause as a simple fall. In the multivariable logistic regression model after controlling for other covariates, the odds of a fall, fracture in the last five years, fractures from simple fall, and osteopenia were respectively 1.46 times (95% confidence interval [CI] 1.42-1.49), 1.26 times (95% CI 1.22-1.30), 1.31 times (95% CI 1.26-1.36) and 1.16 times (95% CI 1.13-1.19) higher for the most deprived compared with the least deprived quantile. CONCLUSION: Socioeconomic deprivation was significantly associated with poor bone health and falls. This research could be beneficial to minimise social disparities in bone health.

Global variation in early epidemic growth rates and reproduction number of seasonal influenza.

BACKGROUND: Little is known about global variation in early epidemic growth rates and effective reproduction numbers (Re) of seasonal influenza. We aimed to estimate global variation in Re of influenza type A and B during a single period. METHODS: Country influenza detection time series from September 2017 through January 2019 were obtained from an international database. Type A and B epidemics by country were selected on the basis of Re estimates for a five-week moving window, advanced by week. Associations of Re with absolute latitude, human development index, percent of the population aged <15 years, and percent of those living in rural areas in each country were assessed. RESULTS: Time series were included for 119 of 169 available countries. There were 100 countries with influenza A and 79 with B epidemics. Median Re for both influenza A and B epidemics was 1.23 (ranges: A 1.10, 1.60; B 1.06, 1.58). Re of influenza B but not A was independently associated with absolute latitude, increasing by 0.022 (95% confidence interval 0.002, 0.043) per 10 degrees. CONCLUSION: The Re of influenza A and B were similar. Only the Re of influenza B was associated with country characteristics, which was increasing with distance from the equator. The approach may be suitable for continuous Re surveillance.