RESUMO
In a mature newborn the symptoms of a disseminated HSV infection were evident at the 6th day of life. Later on bleeding occurred as a result of severe consumption coagulopathy. During treatment with Acyclovir the bleeding situation was controlled by fibrinogen replacement. The infant survived and is under normal psychologic and motorical development now. The treatment result is taken for the good virostatic efficacy of Acyclovir. It inhibits the DNA polymerases and therefore the DNA replication within the herpes viruses selectively. This high degree of selectivity is caused by its selective penetration into the infected cells, its faster transformation by the viral thymidine kinase as well as by its stronger affinity for HSV coded polymerase in detail. The diagnosis had been confirmed by detection of herpes viruses within the blister fluid and cerebrospinal fluid as well as by serological findings.
Assuntos
Coagulação Intravascular Disseminada/congênito , Herpes Simples/congênito , Aciclovir/uso terapêutico , Herpes Simples/tratamento farmacológico , Humanos , Recém-Nascido , MasculinoRESUMO
Chlamydia trachomatis is said to play an important role in the pathogenesis of gynecologic, perinatal and neonatal infectious morbidity. Chlamydia trachomatis is responsible for several infectious syndromes in non-pregnant women, mothers and their offspring. We investigated the incidence of Chlamydia trachomatis in 353 non-pregnant and pregnant women without complaints and in 50 newborn. Chlamydia trachomatis was isolated from 6% of genital carcinoma, about 20% of different gynecological diseases and pregnant women within the first and third trimenon, 35% of puerperas and 10% of newborns. The prevalence of Chlamydia trachomatis antibody occurred in 34 to 55% of the non-pregnant and pregnant women and in 38% of the newborns. We propose a screening for Chlamydia trachomatis infection in high-risk patients and in pregnancy and a treatment of infected individuals.
Assuntos
Infecções por Chlamydia/epidemiologia , Chlamydia trachomatis/isolamento & purificação , Doenças dos Genitais Femininos/complicações , Neoplasias dos Genitais Femininos/complicações , Complicações Infecciosas na Gravidez/epidemiologia , Anticorpos Antibacterianos/análise , Carcinoma in Situ/complicações , Carcinoma in Situ/microbiologia , Colo do Útero/microbiologia , Infecções por Chlamydia/complicações , Infecções por Chlamydia/microbiologia , Chlamydia trachomatis/imunologia , Meato Acústico Externo/microbiologia , Feminino , Doenças dos Genitais Femininos/microbiologia , Neoplasias dos Genitais Femininos/microbiologia , Humanos , Incidência , Recém-Nascido , Cavidade Nasal/microbiologia , Complicações do Trabalho de Parto/microbiologia , Gravidez , Complicações Infecciosas na Gravidez/microbiologia , Primeiro Trimestre da Gravidez , Terceiro Trimestre da Gravidez , Uretra/microbiologia , Neoplasias do Colo do Útero/complicações , Neoplasias do Colo do Útero/microbiologiaRESUMO
Neonatal rat heart muscle primary cell cultures were infected with influenza A viruses. Depending on the infectious dose, functional and structural changes of the heart muscle cells could be registered. The system seems suitable for testing the cytotoxicity of different influenza virus strains.