Polymeric biomolecules based nanomaterials: Production strategies and pollutant mitigation as an emerging tool for environmental application.

The ever-exploding global population coupled with its anthropogenic impact has imparted unparalleled detrimental effects on the environment and mitigating them has emerged as the prime challenge and focus of the current century. The niche of nanotechnology empowered by composites of biopolymers in the handling of xenobiotics and environmental clean-up has an unlimited scope. The appositeness of biopolymer-nanoparticles (Bp-NPs) for environmental contaminant mitigation has received unique consideration due to its exclusive combination of physicochemical characteristics and other attributes. The current review furnishes exhaustive scrutiny of the current accomplishments in the development of Bp-NPs and biopolymer nanomaterials (Bp-NMs) from various polymeric biomolecules. Special attention was provided for polymeric biomolecules such as cellulose, lignin, starch, chitin, and chitosan, whereas limited consideration on gelatin, alginate, and gum for the development of Bp-NPs and Bp-NMs; together with coverage of literature. Promising applications of tailored biopolymer hybrids such as Bp-NPs and Bp-NMs on environmentally hazardous xenobiotics handling and pollution management are discussed as to their notable environmental applications.

Electron beam-irradiated polypyrrole decorated with Bovine serum albumin pores: Simultaneous determination of epinephrine and L-tyrosine.

In current work highly sensitive and stable electrochemical sensor for simultaneous non-enzymatic detection of epinephrine (EP), L-tyrosine (L-Tyr) is constructed based on Electron beam irradiated Polypyrrole (EB-Ppy) nanospheres (Zeta potential 33.69 mV at pH 7) embedded over bovine serum albumin (BSA) (Zeta potential - 11.54 mV at pH 7) porous structure, fabricated by simple chemical routes. The BSA structure has the advantages of large surface area, excellent structure stability, rich pore channels and redox mediator role. The constructed sensor exhibited excellent sensor performances by the combination of protein with NH group and recorded the linear response of EP, L-Tyr individual in the concentration range of 100 nM-1 mM, 100 nM-800 µM, with detection limit 7.1 nM, 8.8 nM (S/N = 3σ/b). The EB-Ppy-BSA/GCE electrochemical sensor manifests intriguing application with good sensitivity, selectivity and reproducibility towards the EP, L-Tyr detection. The practical analytical utility provides great promise by selective measurements in tea, and chicken extract which has a promising future for biological and healthcare applications.

Au-Pd bimetallic nanoparticles anchored on α-Fe2O3 nonenzymatic hybrid nanoelectrocatalyst for simultaneous electrochemical detection of dopamine and uric acid in the presence of ascorbic acid.

We have found that magnetic α-Fe2O3 nanocubes exhibit an intrinsic catalytic activity toward the electrochemical sensing of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid. Au-Pd bimetallic nanoparticles, which act as efficient signal amplifiers, can be attached to the surface of α-Fe2O3 particles to further enhance the catalytic electrochemical signals. The one-step synthesized α-Fe2O3@Au-Pd hybrid nanostructure shows significantly well-separated oxidation peaks with enhanced peak currents of DA and UA. We then demonstrated the use of this nonenzymatic nanoelectrocatalyst for individual detection, and the linear responses of DA and UA were in the concentration ranges of 100 nM-1 mM and 1 µM-1 mM with detection limits of 1.34 × 10-10 M and 1.8 × 10-6 M (S/N = 3σ/b), respectively. For simultaneous detection, the same detection ranges were retained with significantly lower detection limits of 1.38 × 10-11 M and 597 nM, respectively. The fabricated sensor was finally applied in selectivity tests for the detection of DA and UA with satisfactory results. The practical analytical utility was illustrated by selective measurements of human urine, serum and pharmaceutical drugs without any preliminary treatment.

Acalypha indica Linn: Biogenic synthesis of silver and gold nanoparticles and their cytotoxic effects against MDA-MB-231, human breast cancer cells.

This study reports the in vitro cytotoxic effect of biologically synthesized silver and gold nanoparticles against MDA-MB-231, human breast cancer cells. Formation of silver and gold nanoparticles was observed within 30 min and the various characterization techniques such as UV-vis spectrophotometer, FE-SEM, TEM and XRD studies were confirmed the synthesis of nanoparticles. Further, MTT, acridine orange and ethidium bromide (AO/EB) dual staining, caspase-3 and DNA fragmentation assays were carried out using various concentrations of silver and gold nanoparticles ranging from 1 to 100 µg/ml. At 100 µg/ml concentration, the plant extract derived nanoparticles exhibited significant cytotoxic effects and the apoptotic features were confirmed through caspase-3 activation and DNA fragmentation assays. Thus, the results of the present study indicate that biologically synthesized silver and gold nanoparticles might be used to treat breast cancer; however, it necessitates clinical studies to ascertain their potential as anticancer agents.

High prevalence of metabolic syndrome and cardiovascular risk among police personnel compared to general population in India.

OBJECTIVE: There is a paucity of data on the prevalence of metabolic syndrome and diabetes in different occupational categories in India. The aim of this study was to determine the prevalence of metabolic syndrome and associated cardiovascular risk factors among police personnel and compare with the general population (GP). METHODS: Two populations similar in demography were selected for this study. A total of 719 men aged > or = 30 years from Chennai, were randomly selected (police n = 318, GP n = 401). Fasting blood samples were collected, glucose and lipid profile were estimated. Prevalence of metabolic syndrome was determined using IDF definition. Risk associations for metabolic syndrome and diabetes were analyzed using multiple logistic regression analyses. RESULTS: The prevalence of metabolic syndrome (57.3 vs 28.2%; chi2 = 64.5, p < 0.0001) was significantly higher among police compared to GP. Regression analyses showed that age, body mass index, alcohol consumption and smoking were associated with metabolic syndrome while age, family history of diabetes, abdominal adiposity and increased body mass index were associated with diabetes among the policemen. The police had higher prevalence of individual cardio metabolic abnormalities and diabetes in comparison with GP (p < 0.05). CONCLUSION: Prevalence of metabolic syndrome and other cardiometabolic abnormalities were significantly higher among the police. Further research is required to determine the causative factors and effective intervention strategies must be planned to keep the police force healthy and vigilant.