RESUMO
The study involved 97 patients with severe diabetic foot syndrome (DFS) subcompensated type 2 diabetes. All patients were available mediacalcification foot and lower leg arteries of different severity. Depending on the treatment, all patients were divided into 2 groups by stratified randomization. The Ð group received standard therapy, which is indicated for the DFS. A ÐÐ group of patients additionally received basic therapy drug Cytoflavin 10 ml 0,9% NaCl 200 ml for 10 days, followed by transfer to tablet form Cytoflavin 2 tablets 2 times per day orally for one month. We noted a positive trend of treatment of patients who, in addition to standard therapy received the drug Cytoflavin. Thus, the use of complex surgical treatment of patients with mixed form of DFS Cytoflavin reduces the severity of distal polyneuropathy, improves oxygenation of tissues and restores the enzyme activity of antioxidant system, that manifested neuroprotective, antioxidant and anti-hypoxic effects of drugs, which substantiates the indications for its use in the this pathology.
Assuntos
Antioxidantes/uso terapêutico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Pé Diabético/tratamento farmacológico , Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Fármacos Neuroprotetores/uso terapêutico , Niacinamida/uso terapêutico , Succinatos/uso terapêutico , Terapia Combinada , Diabetes Mellitus Tipo 2/complicações , Pé Diabético/etiologia , Pé Diabético/cirurgia , Combinação de Medicamentos , Feminino , Pé/irrigação sanguínea , Humanos , Perna (Membro)/irrigação sanguínea , Masculino , Esclerose Calcificante da Média de Monckeberg/complicações , Esclerose Calcificante da Média de Monckeberg/tratamento farmacológicoRESUMO
The objective of the research was to study the effectiveness of the drug Cytoflavin in the comprehensive treatment of mixed form diabetic foot syndrome with media calcification arteries in 75 elderly patients with type 2 diabetes. Depending on the regimen, patients were divided into two groups: control received basic therapy; main group in addition to the base, received the drug Cytoflavin 10 ml 0,9 % NaCl 200 ml for 10 days, followed by a transition to the tablet form of the drug - 2 tablets 2 times per day orally for one month. The inclusion of the drug Cytoflavin in the treatment regimen increased the effectiveness of treatment, which was shown to improve tissue oxygenation due to the normalization of the basal oxygen tension, restoring the activity of antioxidant enzymes and, consequently, in an authentic decrease in the average time of hospital treatment and a decrease in the number of repeated surgical interventions and reamputatsy over the next year.