[IMMUNE DISORDERS AND THEIR ROLE IN ABORTION].

Objective of the study - to identify the relationship of immunological parameters and their role in termination of pregnancy. 28 women, with a history of 2 or more miscarriages in their medical history, were examined immediately after the termination of pregnancy up to 12 weeks. The control group consisted of 20 healthy non-pregnant women. The content of natural killers of peripheral blood pNK - CD16+, interleukins IL2, IL6, IL10, TNFα; VEGF and γINF were examined by the method of enzyme immunoassay. In women with a history of recurrent miscarriage, immediately after the next termination of pregnancy in the first trimester examinations revealed immune shifts characterized by increased activity pNK - CD16+ compared with the control group - 27.5% (р<0,01); also an increase in the production of interleukins: TNFα to 39.0 pg/ml compared with the control group - 27.5 pg/ml (р<0,05) and IL6 up to 28.5 pg/ml in the control group 13.95 pg/ml (р<0,01). The above changes indicate a dysregulation of the immune system what may be related to the termination of pregnancy in the first trimester.

Bacteriophage Therapy as a Potential Management Option for Surgical Wound Infections.

To investigate the potential role of bacteriophages in the treatment of surgical infections, we conducted a retrospective analysis of four surgical patients who have sought treatment at the Eliava Phage Therapy Center, Tbilisi, Georgia. Two patients had chronic osteomyelitis, one presented with a diabetic foot ulcer, and the fourth patient had developed a severe infectious complication after skin grafting surgery. Patients were treated with different combinations of bacteriophage preparations, based on the sensitivity of the isolated bacterial strain toward commercially available bacteriophages. The treatment lasted on average for 1 month, and positive results were obtained in all four cases: the wounds have healed, the general health status of the patients has improved. No allergic or adverse reactions have been observed throughout the treatment.

Phage therapy against Achromobacter xylosoxidans lung infection in a patient with cystic fibrosis: a case report.

Respiratory infections can lead to serious complications in CF patients, especially when infected with antibiotic resistant bacteria. Alternative treatments for these infections are being sought out to help address this problem. We present a clinical case of a cystic fibrosis (CF) patient, with multi-drug resistant (MDR) Achromobacter xylosoxidans chronic lung infection who was successfully managed with bacteriophage therapy.

[New possibilities for elimination of human papillomavirus from the organism].

The variety of mechanisms of human papillomavirus (HPV) infection suggests that the success of treatment depends on the choice of a universal method, which combines the actions of etiotropic, pathogenetic and symptomatic approaches, without causing unwanted side effect. All these requirements are met by a drug based on the products of plant origin - Indinol. The observed patients with resistant forms of genital warts were divided into 3 groups: first group received the treatment according to the standard, conventional scheme; patients of the second group in addition to the standard scheme 2 times a day (for 90 days) received 2 capsules of Indinol (200 mg) and the patients of third group simultaneously with Indinol undergo infrared irradiation. The results of the observation have shown that the addition of Indinol to the standard treatment had a significant positive effect on the healing process of patients with resistant forms of genital warts. The effects of the Indinol in combination with infrared therapy revealed a statistically significant reduction (3 times) the frequency of relapses in cases of clinically sever forms of disease. Thus, during combined treatment of patients with recurrent, clinically severe forms of genital HPV, it is advisable to use the Indinol, which evidently has the well pronounced virus-eliminative and anti-recurrent actions.