RESUMO
Introduction: Epilepsy is a syndrome of various neurological disorders. Idiosyncratic hepatotoxicity is a rare adverse effect associated with antiepileptic drugs (AED) therapy. Antiepileptic drugs may produce hepatic injury as part of a more widespread hypersensitivity reaction. Laboratory monitoring of asymptomatic effects may allow for the early detection of hepatotoxicity. So the present prospective longitudinal study was carried out to determine the effects of Anticonvulsant drug on liver enzymes among Epileptic Children. Materials Methods: A prospective observational study was conducted among children with seizure disorder attending Paediatric outdoor patient Department of Rajendra Institute of Medical Sciences, Ranchi from February 2014 to October 2015. 50 children with newly diagnosed or untreated seizure disorder were included in case and 50 children of both sexes with same age group as cases were selected as control who did not have seizure. Children with age ranging from 2-10 years were included by consecutive sampling technique. Data was analysed using Statistical Package for Social Sciences (SPSS) software version 25(IBM Corp., Armonk, NY, USA). Paired t test was used to compare the mean values of liver enzymes amongst the children."P-value" was considered to be non - significant if found ≥ 0.05 and significant if P-value was found to be <0.05. Results: In the present study there was no significant alteration of hepatic profile after treatment with valproate except serum alkaline phosphatase which was increased from the initial value than control group and was statistically significantly with P value of less than 0.05. Conclusion: We concluded that these Antiepileptic drugs are safe to use in children up to 1 year.
RESUMO
Background: The objective of this study was to assess the impact of fortified milk on various aspects of growth and development among school children in a tribal-predominant district of Jharkhand, India. Materials and Methods: A longitudinal study was planned in 16 schools (eight in intervention group and eight in control group) of Latehar district of Jharkhand in India. Out of the total 962 study participants, only 528 study participants were considered in study analysis, who were present both during baseline and endline study after 1 year of milk introduction. The study participants were assessed for nutrition, intelligence quotient, and hemoglobin levels with the help of study tools and instruments. Results: The decrease in malnutrition was more evident in the intervention group during endline assessment, with 95% confidence interval (95% CI; 7.37, 7.42) and 95% CI (10.63, 10.58) for the difference in proportion in the intervention and control groups for stunting and thinness, respectively. This was statistically significant (P < 0.05). Anemia also improved with better cognition in the intervention group, and the difference was statistically significant (P < 0.05). Conclusion: In our study, beneficial effects of milk on malnourished children were evident, particularly in combating stunting and thinness, and it also had a positive impact on cognitive skills in school children.