Assuntos
Betacoronavirus/imunologia , Infecções por Coronavirus/epidemiologia , Hidradenite Supurativa/imunologia , Pneumonia Viral/epidemiologia , Guias de Prática Clínica como Assunto , Sistema de Registros/estatística & dados numéricos , Betacoronavirus/patogenicidade , COVID-19 , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/imunologia , Infecções por Coronavirus/terapia , Ciência de Dados , Dermatologia/métodos , Dermatologia/normas , Carga Global da Doença , Hidradenite Supurativa/epidemiologia , Hidradenite Supurativa/terapia , Humanos , Cooperação Internacional , Pandemias , Pneumonia Viral/diagnóstico , Pneumonia Viral/imunologia , Pneumonia Viral/terapia , Prognóstico , Medição de Risco , Fatores de Risco , SARS-CoV-2 , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053-4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.