1.
Stem Cell Res
; 34: 101370, 2019 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30605839
RESUMO
The current prevalence of diagnosable dementia in India is 1% of people over 60â¯years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65â¯years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.