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1.
Anal Bioanal Chem ; 2024 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-39126505

RESUMO

Understanding the relationship between the concentration of a drug and its therapeutic efficacy or side effects is crucial in drug development, especially to understand therapeutic efficacy in central nervous system drug, quantifying drug-induced site-specific changes in the levels of endogenous metabolites, such as neurotransmitters. In recent times, evaluation of quantitative distribution of drugs and endogenous metabolites using matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) has attracted much attention in drug discovery research. However, MALDI-MSI quantification (quantitative mass spectrometry imaging, QMSI) is an emerging technique, and needs to be further developed for practicable and convenient use in drug discovery research. In this study, we developed a reliable QMSI method for quantification of clozapine (antipsychotic drug) and dopamine and its metabolites in the rat brain using MALDI-MSI. An improved mimetic tissue model using powdered frozen tissue for QMSI was established as an alternative method, enabling the accurate quantification of clozapine levels in the rat brain. Furthermore, we used the improved method to evaluate drug-induced fluctuations in the concentrations of dopamine and its metabolites. This method can quantitatively evaluate drug localization in the brain and drug-induced changes in the concentration of endogenous metabolites, demonstrating the usefulness of QMSI.

2.
Chem Commun (Camb) ; 60(39): 5149-5152, 2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38591265

RESUMO

A novel chiral photoswitch composed of a binaphthyl unit and a hexafluorocyclopentene ring has been synthesized. This chiral photoswitch exhibited thermally reversible photochromism between the binaphthyl and helicenoid forms based on 6π-electrocyclization. The helicity of the binaphthyl moiety was reversed upon stereospecific photocyclization and reverted back during the thermal ring opening.

3.
Photochem Photobiol Sci ; 23(1): 133-151, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38129342

RESUMO

A non-photochromic diarylethene 2o with an N-phenylaza-15-crown-5 was synthesized. When the nitrogen atom in the aza-crown ring was protonated, it became photochromic due to the prevention of a twisted intramolecular charge transfer (TICT). Although addition of a monovalent metal cation (Li+, Na+, K+, Rb+, Cs+, Cu+, Ag+) in acetonitrile could not stop the TICT so that it was not photochromic, the addition of a multivalent metal cation (Mg2+, Ca2+, Sr2+, Ba2+, Fe2+, Ni2+, Al3+, Sb5+) changed 2o to be photochromic due to the strong attraction of the lone pair on the nitrogen atom. In the presence of excess Cu2+, 2o was oxidized to be EPR-detectable 2o·+, which was thermally unstable as well as inert towards visible-light irradiation. However, 2o·+ was further oxidized to be fairly stable 2o2+ by the irradiation of 365-nm light in the presence of Cu2+. ESI-MS measurements strongly suggested the generation of 2o·+ by mixing 2o with Cu(ClO4)2 in acetonitrile, and the transformation of 2o·+ to 2o2+ by successive 365-nm light irradiation. Fe3+ similarly worked as the oxidant, but the two-step oxidation of 2o to 2o2+ occurred more easily.

4.
Phys Chem Chem Phys ; 25(41): 28113-28118, 2023 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-37818610

RESUMO

The local ordering of particles is considered an important process in glass transition. Ordering is usually observed in simulation and micrometer-sized colloid. However, clear information on local ordering at the molecular level is difficult to obtain experimentally. In this study, we prepared an easily glass-forming fluorophore with a color change owing to the intermolecular arrangement in the liquid, glass, and crystal states. The bathochromic shifts of the photoluminescence spectra indicated a change in the intermolecular orientation upon immediate cooling of the melt. The recovery of the spectra by successive heating indicated that rotation contributed to the change in the intermolecular orientation. The orientation in the glass was distinct from that during crystal growth, which was observed as a slow bathochromic shift by maintaining the temperature between the melting points of the blue- and green-luminescent crystals obtained from dichloromethane/ethanol and dichloromethane/hexane, respectively. Our results demonstrate that the anisotropic interaction between glass-forming luminophores is useful for uncovering molecular-level events in the glassy state.

5.
J Org Chem ; 86(18): 12549-12558, 2021 09 17.
Artigo em Inglês | MEDLINE | ID: mdl-34324316

RESUMO

Photochromic 1,2-bis(5-carboxy-3-methyl-2-thienyl)hexafluorocyclopentene and its dimethyl ester incorporated in human serum albumin (HSA) showed highly enantioselective photochromic ring-closing reactions upon 366 nm light irradiation. The absolute stereochemistry of the major ring-closed form of the dicarboxylic acid at the newly formed sp3 carbon atoms was determined to be (S,S) by the process of docking simulation of the diarylethene molecule and HSA followed by molecular dynamics calculations and comparison of the measured and calculated CD spectra. Esterification of the major closed form of the diacid gave the minor closed form of the diester. The absolute stereochemistry of the major diester was thus determined to be (R,R).


Assuntos
Albumina Sérica Humana , Tiofenos , Humanos , Estrutura Molecular
6.
Clin Drug Investig ; 40(9): 847-859, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32621143

RESUMO

BACKGROUND AND OBJECTIVES: Topiroxostat, a selective xanthine oxidoreductase inhibitor, is used for the management of hyperuricemic patients with or without gout in Japan. Accumulating evidence has demonstrated the efficacy of topiroxostat for the treatment of hyperuricemia with or without gout. However, the safety and efficacy of topiroxostat in the clinical setting remain unclear, and there is little large-scale clinical evidence. We conducted a post-marketing observational study over 54 weeks. PATIENTS AND METHODS: Patients were centrally enrolled, and case report forms of 4491 patients were collected between April 2014 and March 2019 from 825 medical sites. RESULTS: Overall, 4329 patients were assessed for safety and 4253 patients for effectiveness. The overall incidence of adverse drug reactions was 6.95%, and the incidence rates of adverse drug reactions of gouty arthritis, hepatic dysfunction, and skin disorders, which are of special interest in this study, were 0.79%, 1.73%, and 0.95%, respectively. No case of serious gouty arthritis was observed. Serum urate levels decreased stably over time and showed a significant reduction rate at 54 weeks (21.19% ± 22.07%) and on the final visit (19.91% ± 23.35%) compared to the baseline. The rates for subjects who achieved serum uric acid levels ≤ 6.0 mg/dL at 18 and 54 weeks after administration were 43.80% and 48.28%, respectively. CONCLUSIONS: This study suggests that there is no particular concern about adverse drug reactions or the efficacy of topiroxostat for hyperuricemic patients with or without gout in a post-marketing setting in Japan.


Assuntos
Supressores da Gota/uso terapêutico , Gota/tratamento farmacológico , Hiperuricemia/tratamento farmacológico , Nitrilas/uso terapêutico , Vigilância de Produtos Comercializados , Piridinas/uso terapêutico , Xantina Desidrogenase/antagonistas & inibidores , Adulto , Inibidores Enzimáticos/efeitos adversos , Inibidores Enzimáticos/uso terapêutico , Feminino , Supressores da Gota/efeitos adversos , Humanos , Incidência , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Nitrilas/efeitos adversos , Piridinas/efeitos adversos , Resultado do Tratamento , Ácido Úrico/sangue
7.
Chem Commun (Camb) ; 56(48): 6492-6494, 2020 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-32406882

RESUMO

A thermoresponsive fluorophore based on a photochromic diarylethene possessing donor and acceptor moieties in close proximity to each other has been synthesized. The fluorophore exhibits dual fluorescence, where photoresponsive turn-off switching as well as a thermoresponsive relative intensity change are observed.


Assuntos
Etilenos/química , Corantes Fluorescentes/química , Corantes Fluorescentes/síntese química , Luz , Teoria Quântica , Espectrometria de Fluorescência , Temperatura , Raios Ultravioleta
8.
Biopharm Drug Dispos ; 41(4-5): 151-165, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32187715

RESUMO

This study aimed to investigate the applicability of the Øie-Tozer model to predict human distribution volume (Vd) in the central compartment (V1 ), Vd at steady state (Vdss ), and Vd at beta phase (Vdß ) based on animal Vd. Twenty compounds that have a human V1 /Vdss of 0.053-0.66 were selected from the literature. After intravenous administration of the compounds at 0.1 mg/kg to rats, dogs, and monkeys, plasma concentrations were determined, and pharmacokinetic parameters were obtained by one/two-compartmental analyses. The human V1 , Vdss , and Vdß were predicted from animal Vd using the Øie-Tozer model, and the predictability was compared with that using proportionality and simple allometry. The Øie-Tozer model was the most reliable method for the overall prediction of Vd and applicable for accurately predicting human V1 , Vdss , and Vdß (89%, 85%, and 68% of the compounds within a 3-fold error, respectively) when data of monkey for V1 and data of three animal species for Vdss and Vdß were used. Additionally, the predicted human Vd with the two-compartment model was applicable for predicting pharmacokinetic profiles/parameters in humans after intravenous administration of 18 compounds [except for valproic acid (monophasic elimination profile) and chlorpromazine (deviation: Vdss < V1 )]. The prediction was more accurate than that using the predicted Vdss with the one-compartment model (e.g., underestimation of maximum plasma concentrations: 2 vs 8 compounds within a 3-fold error, respectively). In summary, the Øie-Tozer model was applicable for predicting human V1 , Vdss , and Vdß , and their predicted Vd with the two-compartment model can lead to accurate pharmacokinetic prediction of compounds that show biphasic elimination.


Assuntos
Modelos Biológicos , Animais , Cães , Humanos , Macaca fascicularis , Masculino , Preparações Farmacêuticas/sangue , Preparações Farmacêuticas/metabolismo , Farmacocinética , Ratos Sprague-Dawley
9.
Proc Natl Acad Sci U S A ; 116(40): 19945-19951, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31533957

RESUMO

Cytochrome c oxidase (CcO), a membrane enzyme in the respiratory chain, catalyzes oxygen reduction by coupling electron and proton transfer through the enzyme with a proton pump across the membrane. In all crystals reported to date, bovine CcO exists as a dimer with the same intermonomer contacts, whereas CcOs and related enzymes from prokaryotes exist as monomers. Recent structural analyses of the mitochondrial respiratory supercomplex revealed that CcO monomer associates with complex I and complex III, indicating that the monomeric state is functionally important. In this study, we prepared monomeric and dimeric bovine CcO, stabilized using amphipol, and showed that the monomer had high activity. In addition, using a newly synthesized detergent, we determined the oxidized and reduced structures of monomer with resolutions of 1.85 and 1.95 Å, respectively. Structural comparison of the monomer and dimer revealed that a hydrogen bond network of water molecules is formed at the entry surface of the proton transfer pathway, termed the K-pathway, in monomeric CcO, whereas this network is altered in dimeric CcO. Based on these results, we propose that the monomer is the activated form, whereas the dimer can be regarded as a physiological standby form in the mitochondrial membrane. We also determined phospholipid structures based on electron density together with the anomalous scattering effect of phosphorus atoms. Two cardiolipins are found at the interface region of the supercomplex. We discuss formation of the monomeric CcO, dimeric CcO, and supercomplex, as well as their role in regulation of CcO activity.


Assuntos
Complexo IV da Cadeia de Transporte de Elétrons/química , Mitocôndrias Cardíacas/enzimologia , Animais , Cardiolipinas/química , Bovinos , Cristalografia por Raios X , Digitonina/química , Transporte de Elétrons , Complexo I de Transporte de Elétrons/química , Ligação de Hidrogênio , Concentração de Íons de Hidrogênio , Membranas Mitocondriais/enzimologia , Conformação Molecular , Oxirredução , Oxigênio/química , Fosfolipídeos/química , Fósforo/química , Ligação Proteica , Conformação Proteica , Multimerização Proteica
10.
Biopharm Drug Dispos ; 40(5-6): 165-175, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30924154

RESUMO

The metabolism and pharmacokinetics of DSP-0565 [2-(2'-fluoro[1,1'-biphenyl]-2-yl)acetamide], an antiepileptic drug candidate, was investigated in rats, dogs, and humans. In human hepatocytes, [14 C]DSP-0565 was primarily metabolized via amide bond hydrolysis to (2'-fluoro[1,1'-biphenyl]-2-yl)acetic acid (M8), while in rat and dog hepatocytes, it was primarily metabolized via both hydrolysis to M8 and hydroxylation at the benzene ring or the benzyl site to oxidized metabolites. After single oral administration of [14 C]DSP-0565 to rats and dogs, the major radioactivity fraction was recovered in the urine (71-72% of dose) with a much smaller fraction recovered in feces (23-25% of dose). As primary metabolites in their excreta, M8, oxidized metabolites, and glucuronide of DSP-0565 were detected. The contribution of metabolic pathways was estimated from metabolite profiles in their excreta: the major metabolic pathway was oxidation (57-62%) and the next highest was the hydrolysis pathway (23-33%). These results suggest that there are marked species differences in the metabolic pathways of DSP-0565 between humans and animals. Finally, DSP-0565 human oral clearance (CL/F) was predicted using in vitro-in vivo extrapolation (IVIVE) with/without animal scaling factors (SF, in vivo intrinsic clearance/in vitro intrinsic clearance). The SF improved the underestimation of IVIVE (fold error = 0.22), but the prediction was overestimated (fold error = 2.4-3.3). In contrast, the use of SF for hydrolysis pathway was the most accurate for the prediction (fold error = 1.0-1.4). Our findings suggest that understanding of species differences in metabolic pathways between humans and animals is important for predicting human metabolic clearance when using animal SF.


Assuntos
Acetamidas/farmacocinética , Anticonvulsivantes/farmacocinética , Acetamidas/sangue , Acetamidas/urina , Administração Oral , Adolescente , Adulto , Animais , Anticonvulsivantes/sangue , Anticonvulsivantes/urina , Compostos de Bifenilo , Cães , Fezes/química , Feminino , Hepatócitos/metabolismo , Humanos , Hidrólise , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Oxirredução , Ratos Sprague-Dawley , Método Simples-Cego , Especificidade da Espécie , Adulto Jovem
11.
RSC Adv ; 9(40): 22900-22906, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-35514469

RESUMO

Plasma surface treatment is typically not effective on fluoropolymers containing polytetrafluoroethylene (PTFE). It is reported that heat-assisted plasma (HAP) treatment at high temperatures (above 200 °C) under atmospheric pressure helium (He) plasma improves the adhesion properties of PTFE. In this study, we investigated the influence of the air concentration during HAP treatment on the adhesion properties of PTFE. Air concentration was controlled via ambient air inflow amount, in other words, base pressure. The PTFE samples HAP-treated in different air concentrations were thermally compressed with an unvulcanized isobutylene-isoprene rubber (IIR). Then, the PTFE/IIR adhesion strength was measured via T-peel test. We show that, when PTFE was HAP-treated in 0.01% air, its PTFE/IIR adhesion strength was over 2 N mm-1; the IIR underwent cohesion failure. However, the PTFE/IIR adhesion strength drastically decreased in the presence of air contamination. The relationships between air concentration during HAP treatment, adhesion properties of PTFE, surface chemical composition, surface morphology, and surface hardness were investigated and discussed.

12.
Chem Commun (Camb) ; 54(26): 3207-3210, 2018 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-29411834

RESUMO

A spiro-functionalized photochromic diarylethene derivative showed multi-colour fluorescence modulation with a photon-quantitative photocyclization reactivity and high thermal stability.

13.
J Pharm Sci ; 106(9): 2509-2514, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28465153

RESUMO

We previously reported a cell-based toxicity assay using sandwich-cultured hepatocytes in combination with a titrated amount of human bile acid (BA) species. In this assay, test compound-induced inhibition of BA efflux from sandwich-cultured hepatocytes leads to BA-dependent cell toxicity (BAtox, i.e., cell death due to the accumulation of BAs). Using this assay, we investigated whether 1-aminobenzotriazole (1-ABT; a nonselective cytochrome P450 inhibitor) enhanced or suppressed test compound-induced BAtox. There was a tendency that BAtox of many compounds was enhanced by 1-ABT in human hepatocytes; in contrast, such a tendency was not observed in rat hepatocytes. In particular, 1-ABT tended to enhance BAtox of several compounds (clopidogrel, ticlopidine, everolimus, etc.) in human, whereas 1-ABT tended to enhance BAtox of only ticlopidine in rat. These results indicate that this system can be used to evaluate BAtox while taking into account drug metabolism and the existence of an interspecies difference in the effect of 1-ABT treatment on BAtox.


Assuntos
Ativação Metabólica , Antagonistas dos Receptores de Hormônios Antidiuréticos/toxicidade , Benzazepinas/toxicidade , Ácidos e Sais Biliares/metabolismo , Inibidores das Enzimas do Citocromo P-450/farmacologia , Hepatócitos/efeitos dos fármacos , Triazóis/farmacologia , Ativação Metabólica/efeitos dos fármacos , Animais , Antagonistas dos Receptores de Hormônios Antidiuréticos/metabolismo , Benzazepinas/metabolismo , Transporte Biológico/efeitos dos fármacos , Células Cultivadas , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Colestase/induzido quimicamente , Colestase/metabolismo , Sistema Enzimático do Citocromo P-450/metabolismo , Hepatócitos/citologia , Hepatócitos/metabolismo , Humanos , Masculino , Ratos , Ratos Sprague-Dawley , Tolvaptan , Testes de Toxicidade
14.
Toxicol Sci ; 158(2): 347-355, 2017 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-28486596

RESUMO

Troglitazone and pioglitazone were developed as thiazolidinedione-type antidiabetes drugs, but only troglitazone was withdrawn from the markets due to severe liver injury. As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury. However, pioglitazone is also a strong BSEP inhibitor, indicating other mechanisms may also be involved in troglitazone-induced BA retention. Although retention of hydrophobic BAs (eg, chenodeoxycholic acid [CDCA]: a nonamidated BA) is known to cause hepatocyte injury, little is known about the hepatic conversion of nonamidated, hydrophobic BA species into less toxic hydrophilic BAs (eg, glycochenodeoxycholic acid: amidated BA) as a mechanism of drug-induced liver injury. In this study, we, therefore, investigated the effects of troglitazone and pioglitazone on BA amidation and the role of amidated BAs in troglitazone-associated BA-mediated hepatotoxicity. We also evaluated the intracellular BA composition of human hepatocytes treated with nonamidated BA species (CDCA or deoxycholic acid [DCA]) in the presence of troglitazone or pioglitazone. Amidation of CDCA and DCA was significantly inhibited by troglitazone (IC50: 5 and 3 µmol/l, respectively), but not pioglitazone. Moreover, treatment with troglitazone led to the retention of CDCA and DCA and decrease of glycine-amidation in hepatocytes. From these results, we suggest that troglitazone-induced liver injury might be caused by the accumulation of nonamidated BAs in hepatocytes due to inhibition of BA amidation.


Assuntos
Amidas/metabolismo , Ácidos e Sais Biliares/metabolismo , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Cromanos/efeitos adversos , Hipoglicemiantes/efeitos adversos , Tiazolidinedionas/efeitos adversos , Células Cultivadas , Humanos , Fatores de Risco , Troglitazona
15.
Org Lett ; 18(19): 5042-5045, 2016 10 07.
Artigo em Inglês | MEDLINE | ID: mdl-27662504

RESUMO

Upon visible light irradiation, a thermally reversible photochromic acid generator merocyanine dye gives a proton to the dimethylamino group of a non-photochromic diarylethene in acetonitrile. The protonation rendered the non-photochromic diarylethene photochromic. Thus, the thermally irreversible photochromic nature of the diarylethene is activated without any physical contact or addition of any compound but only by photoirradiation to the merocyanine dye.

16.
Photochem Photobiol Sci ; 15(3): 325-8, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26906945

RESUMO

An on/off switching for charge-transfer interactions between the side chains of a diarylethene based on photochromic reactions has been proved by the disappearance and appearance of an additional fluorescence band.


Assuntos
Alcinos/química , Fluorescência , Fótons , Estrutura Molecular , Espectrometria de Fluorescência
17.
J Immunotoxicol ; 12(3): 247-60, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25046026

RESUMO

Amodiaquine (AQ) treatment is associated with a high incidence of idiosyncratic drug-induced liver injury (IDILI) and agranulocytosis. Evidence suggests that AQ-induced IDILI is immune mediated. A significant impediment to mechanistic studies of IDILI is the lack of valid animal models. This study reports the first animal model of IDILI with characteristics similar to mild IDILI in humans. Treatment of female C57BL/6 mice with AQ led to liver injury with delayed onset, which resolved despite continued treatment. Covalent binding of AQ was detected in the liver, which was greater in female than in male mice, and higher in the liver than in other organs. Covalent binding in the liver was maximal by Day 3, which did not explain the delayed onset of alanine aminotransferase (ALT) elevation. However, coincident with the elevated serum ALT, infiltration of liver and splenic mononuclear cells and activation of CD8 T-cells within the liver were identified. By Week 7, when ALT levels had returned close to normal, down-regulation of several inflammatory cytokines and up-regulation of PD-1 on T-cells suggested induction of immune tolerance. Treatment of Rag1(-/-) mice with AQ resulted in higher ALT activities than C57BL/6 mice, which suggested that the adaptive immune response was responsible for immune tolerance. In contrast, depletion of NK cells significantly attenuated the increase in ALT, which implied a role for NK cells in mild AQ-induced IDILI. This is the first example of a delayed-onset animal model of IDILI that appears to be immune-mediated.


Assuntos
Agranulocitose/imunologia , Amodiaquina/efeitos adversos , Linfócitos T CD8-Positivos/efeitos dos fármacos , Doença Hepática Induzida por Substâncias e Drogas/imunologia , Células Matadoras Naturais/imunologia , Fígado/metabolismo , Imunidade Adaptativa/genética , Alanina Transaminase/metabolismo , Amodiaquina/administração & dosagem , Animais , Linfócitos T CD8-Positivos/imunologia , Progressão da Doença , Feminino , Proteínas de Homeodomínio/genética , Humanos , Tolerância Imunológica/genética , Fígado/efeitos dos fármacos , Fígado/patologia , Ativação Linfocitária/efeitos dos fármacos , Depleção Linfocítica , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Mutantes , Modelos Animais
19.
Int J Clin Exp Pathol ; 6(12): 2949-54, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24294383

RESUMO

Leiomyomatosis peritonealis disseminata (LPD) is an extremely rare condition, which is characterized by the presence of multiple peritoneal and subperitoneal nodules composed of bland smooth muscle cells. Albeit extremely rare, coexistence of endometriosis within LPD lesions has also reported. Herein, we report the seventh documented case of LPD coexisting with endometriosis within the same lesions and review the pathogenesis of this lesion. A 42-year-old Japanese female presented with an abdominal tumor. Computed tomography revealed a tumorous lesion in the right ovary and multiple small nodules in the abdominal cavity. Under a clinical diagnosis of ovarian cancer with peritoneal dissemination, resection of these lesions was performed. Histopathological study of the disseminated peritoneal nodules revealed proliferation of interlacing bundles of spindle cells with eosinophilic cytoplasm and bland cigar-shaped nuclei. Mitotic figures were hardly seen. The peritoneal nodules of the rectum had cystic cavities within the spindle cell bundles, and endometrial glands and stroma were present around the cystic cavities and spindle cells. The resected tissues of the ovary and cecum showed the same histopathological features. Accordingly, a diagnosis of LPD with endometriosis within the same lesions was made. A possible origin of LPD is thought to be the submesothelial multipotential stem cells, also referred to as the secondary müllerian system. The presence of endometrial tissues within LPD lesions, as seen in the present case, also support this hypothesis because endometrial tissues are also derived from the müllerian system.


Assuntos
Endometriose/complicações , Leiomiomatose/complicações , Neoplasias Ovarianas/complicações , Neoplasias Peritoneais/complicações , Adulto , Biomarcadores Tumorais/análise , Biópsia , Endometriose/diagnóstico , Endometriose/cirurgia , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Intestinais/complicações , Neoplasias Intestinais/secundário , Leiomiomatose/química , Leiomiomatose/patologia , Leiomiomatose/cirurgia , Neoplasias Ovarianas/química , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/cirurgia , Neoplasias Peritoneais/química , Neoplasias Peritoneais/secundário , Neoplasias Peritoneais/cirurgia
20.
Sci Rep ; 3: 3344, 2013 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-24276090

RESUMO

Thermoelectrics is a challenging issue for modern and future energy conversion and recovery technology. Carbon nanotubes are promising active thermoelectic materials owing to their narrow bandgap energy and high charge carrier mobility, and they can be integrated into flexible thermoelectrics that can recover any waste heat. We here report air-stable n-type single walled carbon nanotubes with a variety of weak electron donors in the range of HOMO level between ca. -4.4 eV and ca. -5.6 eV, in which partial uphill electron injection from the dopant to the conduction band of single walled carbon nanotubes is dominant. We display flexible films of the doped single walled carbon nanotubes possessing significantly large thermoelectric effect, which is applicable to flexible ambient thermoelectric modules.

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