1.
Intern Med
; 62(14): 2159-2160, 2023 07 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37081677
Assuntos
COVID-19 , Doença de Leigh , Humanos , COVID-19/complicações , Vasoconstrição , SARS-CoV-2 , Síndrome , Vacinação
2.
Intern Med
; 62(13): 1995-1998, 2023 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36543208
RESUMO
A 26-year-old woman developed a sudden headache, ptosis, and diplopia. Magnetic resonance imaging and angiography demonstrated a symmetrical lesion from the midbrain to the brainstem, involving the solitary nucleus and multifocal cerebral artery narrowing. Reversible cerebral vasoconstriction syndrome (RCVS) was suspected, and the patient improved after vasodilatation. Leigh syndrome was suspected due to the elevated serum pyruvate level, so mitochondrial DNA was analyzed, and an m.9176T>C mutation was detected. The final diagnosis was adult-onset Leigh syndrome manifesting as RCVS. An uncontrolled baroreflex due to a solitary nuclear lesion or endothelial dysfunction may have contributed to her unique presentation.