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1.
J Colloid Interface Sci ; 675: 488-495, 2024 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-38986322

RESUMO

As a promising sustainable power source in intelligent electronics, Triboelectric Nanogenerators (TENGs) have garnered widespread interest, with various strategies explored to enhance their output performance. However, most optimization methods for triboelectric materials have focused solely on tuning chemical compositions or fabricating surface microstructures. Here, we have prepared amino-functionalized reduced graphene oxide (FRGO)/polyimide (PI) composite films (PI-FRGO) via in-situ polymerization, aimed at enhancing PI materials' nanotribological power generation performance. By varying the doping levels of amino groups and controlling the FRGO proportion during synthesis, we can explore the optimal FRGO/PI composite film ratio. At a p-Phenylenediamine: reduced Graphene Oxide (PPDA: RGO) ratio of 1:1 and an FRGO addition of 0.1 %, the output electrical performance peaks with a voltage of 58 V, a charge of 33 nC and a current of 12 µA, nearly 2 times that of a pure PI film. We have fabricated a TENG with an optimally formulated PI-FRGO composite to explore its application potential. Under a 10 MΩ external load resistance, the TENG can deliver a power density of 3.5 mW/m2 and can be powering small devices. This work presents new effective strategies to significantly enhance TENG output performance and promote their widespread application.

2.
Neurotherapeutics ; : e00387, 2024 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-38918128

RESUMO

The precise oxygen content thresholds of ischemic deep parenchymal (OCIDP) and that in cortical microcirculation (OCCM), which leads to ischemic penumbra converting into the infarcted core, remain uncertain. This study employed an invasive fiber-optic oxygen meter and a newly developed oxygen-responsive probe called RuA3-Cy5-rtPA (RC-rtPA) based on recombinant tissue-type plasminogen activator (rtPA) to examine the oxygen content thresholds. A mouse model of middle cerebral artery occlusion was generated and animals were randomly divided into a sham, 24-h reperfusion after 3-h ischemia (IR 3-h), and IR 6-h groups, all of which were sacrificed following reperfusion. Stroke severity was evaluated based on the infarction area, neurological symptoms, microcirculation perfusion, and microemboli in microcirculation. OCIDP was characterized based on its extent and distribution, whereas OCCM was measured using RC-rtPA. During ischemia, stroke severity escalation manifested as increasing infarction area, severe neurologic symptoms, and poorer microcirculation perfusion with more microthrombi depositions. OCIDP presented rapid decline following artery occlusion along with a gradual increase in the hypoxic area. Within 3 â€‹h following ischemia induction, the ischemic tissue that experienced hypoxia could be rescued, and this reversibility would disappear after 6 â€‹h. Within 6 â€‹h, OCCM continued to decrease. A significant decrease in oxygen content in cortical venules and cortical parenchyma was observed. These findings assist in establishing the extent of the ischemic penumbra at the microcirculation level and offer a foundation for assessing the ischemic penumbra that could respond positively to reperfusion therapy beyond the typical time window.

3.
J Colloid Interface Sci ; 671: 336-343, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-38815370

RESUMO

Against the backdrop of advancements in modern multifunctional wearable electronics, there is a growing demand for simple, sustainable, and portable electronic skin (e-skin), posing significant challenges. This study aims to delineate the development of a straightforward, transparent, highly sensitive, and high power-density electronic skin based on a triboelectric nanogenerator(S-TENG), designed for harvesting human body energy and real-time monitoring of the physiological motion status. Our e-skin incorporates thermally treated polyvinylidene fluoride (PVDF) fiber membranes as the contact layer and a film of silver nanowires as the conductive electrodes. The resulting contact-separation type e-skin exhibits an impressive transparency of 80 %, along with a nice sensitivity value, capable of detecting a light touch from a 0.13 g sponge and demonstrating good working stability and breathability. Leveraging the triboelectric effect, our e-skin generates an open-circuit voltage of 301 V and a short-circuit current of 2.7 µA under an extrinsic force of 8 N over an interaction area of 4 × 4 cm2, achieving a power density up to 306 mW/m2. With its signal processing circuitry, the integrated S-TENG showcases nice energy harvesting and signal transmission capabilities. Accordingly, we contend that S-TENG has potential applications in energy capture and real-time human motion state monitoring. This research is anticipated to blaze a novel and practical trail for self-powered wearable devices and personalized health rehabilitation training regimens.


Assuntos
Fontes de Energia Elétrica , Dispositivos Eletrônicos Vestíveis , Humanos , Nanotecnologia , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Nanofios/química , Prata/química , Polivinil/química , Eletrodos , Propriedades de Superfície , Testes Respiratórios/instrumentação , Polímeros de Fluorcarboneto
4.
Molecules ; 29(9)2024 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-38731417

RESUMO

In recent years, renewable and sustainable triboelectric nanogenerators have attracted attention due to their high energy conversion rate, and enhancing their functionality further contributes to their applicability across various fields. A pH-sensitive triboelectric nanogenerator (pH-TENG) has been prepared by electrostatic spinning technology, with anthocyanin as the pH indicator and environmentally friendly polyvinyl alcohol (PVA) as the substrate. Among many friction-negative materials, the pH-TENG exhibits the best combination with fluorinated ethylene propylene (FEP) and yields an open-circuit voltage of 62 V, a short-circuit current of 370 nA, and a transferred charge of 21.8 nC. At a frequency of 3 Hz, it can charge a 4.7 µF capacitor to 2 V within 45 s, effectively powering a thermometer. Furthermore, the presence of anthocyanin does not affect the pH-TENG's power generation performance and enables the monitoring of a wide range of environmental pH changes, with an ΔE change of 28.8 ± 7.6. Therefore, pH-TENG prepared with environmentally friendly materials can bring new available materials to the biological and medical fields.

5.
Cell Death Dis ; 15(4): 291, 2024 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-38658569

RESUMO

Annexin A2 (ANXA2) is a widely reported oncogene. However, the mechanism of ANXA2 in esophageal cancer is not fully understood. In this study, we provided evidence that ANXA2 promotes the progression of esophageal squamous cell carcinoma (ESCC) through the downstream target threonine tyrosine kinase (TTK). These results are consistent with the up-regulation of ANXA2 and TTK in ESCC. In vitro experiments by knockdown and overexpression of ANXA2 revealed that ANXA2 promotes the progression of ESCC by enhancing cancer cell proliferation, migration, and invasion. Subsequently, animal models also confirmed the role of ANXA2 in promoting the proliferation and metastasis of ESCC. Mechanistically, the ANXA2/TTK complex activates the Akt/mTOR signaling pathway and accelerates epithelial-mesenchymal transition (EMT), thereby promoting the invasion and metastasis of ESCC. Furthermore, we identified that TTK overexpression can reverse the inhibition of ESCC invasion after ANXA2 knockdown. Overall, these data indicate that the combination of ANXA2 and TTK regulates the activation of the Akt/mTOR pathway and accelerates the progression of ESCC. Therefore, the ANXA2/TTK/Akt/mTOR axis is a potential therapeutic target for ESCC.


Assuntos
Anexina A2 , Proliferação de Células , Progressão da Doença , Transição Epitelial-Mesenquimal , Neoplasias Esofágicas , Proteínas Proto-Oncogênicas c-akt , Transdução de Sinais , Serina-Treonina Quinases TOR , Humanos , Serina-Treonina Quinases TOR/metabolismo , Anexina A2/metabolismo , Anexina A2/genética , Proteínas Proto-Oncogênicas c-akt/metabolismo , Neoplasias Esofágicas/patologia , Neoplasias Esofágicas/metabolismo , Neoplasias Esofágicas/genética , Animais , Linhagem Celular Tumoral , Transição Epitelial-Mesenquimal/genética , Camundongos Nus , Camundongos , Carcinoma de Células Escamosas do Esôfago/patologia , Carcinoma de Células Escamosas do Esôfago/metabolismo , Carcinoma de Células Escamosas do Esôfago/genética , Movimento Celular , Proteínas de Ciclo Celular/metabolismo , Proteínas de Ciclo Celular/genética , Masculino , Camundongos Endogâmicos BALB C , Invasividade Neoplásica , Regulação Neoplásica da Expressão Gênica , Feminino
6.
Materials (Basel) ; 17(5)2024 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-38473690

RESUMO

Waterborne epoxy (WEP) coatings with enhanced corrosion resistance were prepared using graphene oxide (GO) that was obtained from kish graphite, and amino-functionalized graphene oxide (AGO) was modified by 2-aminomalonamide. The structural characteristics of the GO and AGO were analyzed using X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). And the anti-corrosive performance of waterborne epoxy-cased composite coatings with different addition amounts of AGO was investigated using electrochemical measurements, pull-off adhesion tests, and salt spray tests. The results indicate that AGO15/WEP with 0.15 wt.% of AGO has the best anti-corrosive performance, and the lowest frequency impedance modulus increased from 1.03 × 108 to 1.63 × 1010 ohm·cm-2 compared to that of WEP. Furthermore, AGO15/WEP also demonstrates the minimal corrosion products or bubbles in the salt spray test for 200 h, affirming its exceptional long-term corrosion protection capability.

7.
PLoS One ; 19(2): e0298735, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38412178

RESUMO

Recombination innovation invented during organizations' research and development (R&D) collaborations is a vital mechanism for creating new technological knowledge for organizations. This study aims to reveal the contribution mechanism of different dimensions of proximity to the recombination innovation at the collaborative dyad level and how this mechanism depends on the characteristics of organizations' knowledge base structuration. We conceptualize that the interdependence among knowledge elements in the knowledge base forms the knowledge space of the organization and build a theoretical framework to explain the interactive effect of proximity and organizations' knowledge base characteristics on collaborative recombination innovation. We validated the theoretical hypotheses using Logit regression models based on the longitudinal data of 150 organizations in the global nanotechnology industry. As demonstrated by our findings, technological proximity exerts a negative effect, while geographic proximity exerts an inverted U-shaped effect on collaborative organizations' joint recombination innovation. Organizations' knowledge base decomposability plays a negative role in moderating the effect of technological proximity and plays a positive role in regulating the effect of geographic proximity. In contrast, the degree centrality of the knowledge elements positively moderates the effect of both technological and geographic proximity.


Assuntos
Pesquisa , Tecnologia , Indústrias , Nanotecnologia , Recombinação Genética , China
8.
Neurocrit Care ; 40(1): 225-236, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37208490

RESUMO

BACKGROUND: Iron overload plays an important role in hydrocephalus development following intraventricular hemorrhage (IVH). Aquaporin 4 (AQP4) participates in the balance of cerebrospinal fluid secretion and absorption. The current study investigated the role of AQP4 in the formation of hydrocephalus caused by iron overload after IVH. METHODS: There were three parts to this study. First, Sprague-Dawley rats received an intraventricular injection of 100 µl autologous blood or saline control. Second, rats had IVH and were treated with deferoxamine (DFX), an iron chelator, or vehicle. Third, rats had IVH and were treated with 2-(nicotinamide)-1,3,4-thiadiazole (TGN-020), a specific AQP4 inhibitor, or vehicle. Rats underwent T2-weighted and T2* gradient-echo magnetic resonance imaging to assess lateral ventricular volume and intraventricular iron deposition at 7, 14, and 28 days after intraventricular injection and were then euthanized. Real-time quantitative polymerase chain reaction, western blot analysis, and immunofluorescence analyses were conducted on the rat brains to evaluate the expression of AQP4 at different time points. Hematoxylin and eosin-stained brain sections were obtained to assess the ventricular wall damage on day 28. RESULTS: Intraventricular injection of autologous blood caused a significant ventricular dilatation, iron deposition, and ventricular wall damage. There was increased AQP4 mRNA and protein expression in the periventricular tissue in IVH rats through day 7 to day 28. The DFX treatment group had a lower lateral ventricular volume and less intraventricular iron deposition and ventricular wall damage than the vehicle-treated group after IVH. The expression of AQP4 protein in periventricular tissue was also inhibited by DFX on days 14 and 28 after IVH. The use of TGN-020 attenuated hydrocephalus development after IVH and inhibited the expression of AQP4 protein in the periventricular tissue between day 14 and day 28 without a significant effect on intraventricular iron deposition or ventricular wall damage. CONCLUSIONS: AQP4 located in the periventricular area mediated the effect of iron overload on hydrocephalus after IVH.


Assuntos
Hidrocefalia , Sobrecarga de Ferro , Niacinamida , Tiadiazóis , Animais , Ratos , Aquaporina 4/uso terapêutico , Hemorragia Cerebral/tratamento farmacológico , Hidrocefalia/etiologia , Injeções Intraventriculares , Ferro/metabolismo , Sobrecarga de Ferro/complicações , Niacinamida/análogos & derivados , Ratos Sprague-Dawley
9.
Heliyon ; 9(11): e22403, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38045216

RESUMO

The Low utilization and high cost of platinum counter electrode (CE) in the application of dye-sensitized solar cells has limited its large-scale manufacturing in the industry. Herein, a facile pyrolysis combination of Pt and SBA-15 molecular sieve (MS) formed 1.6-1.9 times higher amount and 2-3 times reduced dimension of Pt distributed within porous structure of SBA-15. The composite CE with 20 % of SBA-15 exhibited an enhanced power conversion efficiency of 9.31 %, exceeding that of absolute Pt CE (7.57 %). This superior performance owed to the promoted oxidation-reduction rate of I3-/I- pairs at the CE interface and the increased conductivity of CE materials attributed from well distributed Pt particles. This work has demonstrated the significance of utilizing porous molecular sieves for dispersing catalytic sites when designing a novel type of counter electrode and their application in DSSCs.

10.
Mol Neurobiol ; 60(11): 6530-6541, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37458988

RESUMO

The non-receptor protein tyrosine phosphatase is a class of enzymes that catalyze the dephosphorylation of phosphotyrosines in protein molecules. They are involved in cellular signaling by regulating the phosphorylation status of a variety of receptors and signaling molecules within the cell, thereby influencing cellular physiological and pathological processes. In this article, we detail multiple non-receptor tyrosine phosphatase and non-receptor tyrosine phosphatase genes involved in the pathological process of brain disease. These include PTPN6, PTPN11, and PTPN13, which are involved in glioma signaling; PTPN1, PTPN5, and PTPN13, which are involved in the pathogenesis of Alzheimer's disease Tau protein lesions, PTPN23, which may be involved in the pathogenesis of Epilepsy and PTPN1, which is involved in the pathogenesis of Parkinson's disease. The role of mitochondrial tyrosine phosphatase in brain diseases was also discussed. Non-receptor tyrosine phosphatases have great potential for targeted therapies in brain diseases and are highly promising research areas.


Assuntos
Doença de Alzheimer , Proteínas Tirosina Fosfatases não Receptoras , Humanos , Proteínas Tirosina Fosfatases não Receptoras/metabolismo , Transdução de Sinais/fisiologia , Fosforilação , Doença de Alzheimer/metabolismo , Encéfalo/metabolismo , Tirosina/metabolismo
11.
Artigo em Inglês | MEDLINE | ID: mdl-37489703

RESUMO

Serum miRNAs are available clinical samples for cancer screening. Identifying early serum markers in lung cancer (LC) is essential for patients' early diagnosis and clinical treatment. Expression data of serum miRNAs of lung adenocarcinoma (LUAD) patients and healthy individuals were downloaded from the Gene Expression Omnibus (GEO). These data were normalized and subjected to differential expression analysis to obtain differentially expressed miRNAs (DEmiRNAs). The DEmiRNAs were subsequently subjected to ReliefF feature selection, and subsets closely related to cancer were screened as candidate feature miRNAs. Thereafter, a Gaussian Naive Bayes (NB), Support Vector Machine (SVM), and Random Forest (RF) classifier were constructed based on these candidate feature miRNAs. Then the best diagnostic signature was constructed through NB combined with incremental feature selection (IFS). Thereafter, these samples were subjected to principal component analysis (PCA) based on miRNAs with optimal predictive performance. Finally, the peripheral serum miRNAs of 64 LUAD patients and 59 normal individuals were extracted for qRT-PCR analysis to validate the performance of the diagnostic model in respect of clinical detection. Finally, according to area under the curve (AUC) and accuracy values, the NB classifier composed of miR-5100 and miR-663a manifested the most outstanding diagnostic performance. The PCA results also revealed that the 2-miRNA diagnostic signature could effectively distinguish cancer patients from healthy individuals. Finally, qRT-PCR results of clinical serum samples revealed that miR-5100 and miR-663a expression in tumor samples was remarkably higher than that in normal samples. The AUC of the 2-miRNA diagnostic signature was 0.968. In summary, we identified markers (miR-5100 and miR-663a) in serum for early LUAD screening, providing ideas for developing early LUAD diagnostic models.

12.
Diagn Pathol ; 18(1): 33, 2023 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-36864456

RESUMO

BACKGROUND: Lung adenocarcinoma (LUAD) is a prevalent malignancy. SNHG15 has been demonstrated to be oncogenic in many kinds of cancers, however the mechanism of SNHG15 in LUAD cisplatin (DDP) resistance remains unclear. In this study, we demonstrated the effect of SNHG15 on DDP resistance in LUAD and its related mechanism. METHODS: Bioinformatics analysis was adopted to assess SNHG15 expression in LUAD tissues and predict the downstream genes of SNHG15. The binding relationship between SNHG15 and downstream regulatory genes was proved through RNA immunoprecipitation, chromatin immunoprecipitation and dual-luciferase reporter assays. Cell counting kit-8 assay was adopted to evaluate LUAD cell viability, and gene expression was determined by Western blot and quantitative real-time polymerase chain reaction. We then performed comet assay to assess DNA damage. Cell apoptosis was detected by Tunnel assay. Xenograft animal models were created to test the function of SNHG15 in vivo. RESULTS: SNHG15 was up-regulated in LUAD cells. Moreover, SNHG15 was also highly expressed in drug-resistant LUAD cells. Down-regulated SNHG15 strengthened the sensitivity of LUAD cells to DDP and induced DNA damage. SNHG15 could elevate ECE2 expression through binding with E2F1, and it could induce DDP resistance by modulating the E2F1/ECE2 axis. In vivo experiments verified that the SNHG15 could enhance DDP resistance in LUAD tissue. CONCLUSION: The results suggested that SNHG15 could up-regulate ECE2 expression by recruiting E2F1, thereby enhancing the DDP resistance of LUAD.


Assuntos
Adenocarcinoma de Pulmão , Adenocarcinoma , Neoplasias Pulmonares , Animais , Humanos , Cisplatino/farmacologia , Adenocarcinoma de Pulmão/tratamento farmacológico , Adenocarcinoma de Pulmão/genética , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/genética , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/genética , Reparo do DNA/genética
13.
Front Pharmacol ; 14: 1084564, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36909178

RESUMO

Several studies have demonstrated the protective effect of dl-3-n-Butylphthalide (NBP) against cerebral ischemia, which may be related to the attenuation of mitochondrial dysfunction. However, the specific mechanism and targets of NBP in cerebral ischemia/reperfusion remains unclear. In this study, we used a chemical proteomics approach to search for targets of NBP and identified cytochrome C oxidase 7c (Cox7c) as a key interacting target of NBP. Our findings indicated that NBP inhibits mitochondrial apoptosis and reactive oxygen species (ROS) release and increases ATP production through upregulation of Cox7c. Subsequently, mitochondrial respiratory capacity was improved and the HIF-1α/VEGF pathway was upregulated, which contributed to the maintenance of mitochondrial membrane potential and blood brain barrier integrity and promoting angiogenesis. Therefore, our findings provided a novel insight into the mechanisms underlying the neuroprotective effects of NBP, and also proposed for the first time that Cox7c exerts a critical role by protecting mitochondrial function.

14.
Gynecol Endocrinol ; 39(1): 2173948, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36750132

RESUMO

Objective: The aim of this study was to investigate the endometrial proteomic profiles of patients with polycystic ovary syndrome (PCOS) with and without insulin resistance (IR). Method of Study: We collected 40 endometrial samples, including PCOS-IR (n = 21), PCOS-non-IR (n = 12), and control (n = 7). Data-independent acquisition (DIA)-based proteomics method is used to identify the expressed proteins among the three groups. The correlation between pregnancy outcomes and identified proteins was analyzed by Lasso regression. Results: A total of 5331 proteins were identified, while 275 proteins were differentially expressed in the PCOS vs. control group and 215 proteins were differentially expressed in the PCOS-IR vs. PCOS-non-IR group. Platelet degranulation, neutrophil degranulation, and very long-chain fatty acid catabolic processes have been found to play important roles in the endometrium of patients with PCOS-IR. Lasso regression analysis found that ACTR1A, TSC22D2, CKB, ABRAXAS2, and TAGLN2 were associated with miscarriage in patients with PCOS. ACTR1A and CKB were higher in the PCOS-IR group and were positively correlated with HOMA-IR (p < .05). Conclusion: In this study, a panel of proteins was found to be differently expressed in the endometrium. ACTR1A and CKB may be considered as PCOS-IR candidate biomarkers.


Assuntos
Resistência à Insulina , Síndrome do Ovário Policístico , Feminino , Gravidez , Humanos , Síndrome do Ovário Policístico/complicações , Síndrome do Ovário Policístico/metabolismo , Proteômica , Endométrio/metabolismo , Resultado da Gravidez , Insulina/metabolismo , Proteínas de Ligação a DNA/metabolismo , Fatores de Transcrição/metabolismo
15.
Eur Neurol ; 86(2): 85-94, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36617418

RESUMO

BACKGROUND: The no-reflow phenomenon refers to a failure to restore normal cerebral microcirculation despite brain large artery recanalization after acute ischemic stroke, which was observed over 50 years ago. SUMMARY: Different mechanisms contributing to no-reflow extend across the endovascular, vascular wall, and extravascular factors. There are some clinical tools to evaluate cerebral microvascular hemodynamics and represent biomarkers of the no-reflow phenomenon. As substantial experimental and clinical data showed that clinical outcome was better correlated with reperfusion status rather than recanalization in patients with ischemic stroke, how to address the no-reflow phenomenon is critical. But effective treatments for restoring cerebral microcirculation have not been well established until now, so there is an urgent need for novel therapeutic perspectives to improve outcomes after recanalization therapies. CONCLUSION: Here, we review the occurrence of the no-reflow phenomenon after ischemic stroke and discuss its impact, detection method, and therapeutic strategies on the course of ischemic stroke, from basic science to clinical findings.


Assuntos
AVC Isquêmico , Fenômeno de não Refluxo , Acidente Vascular Cerebral , Humanos , Microcirculação , Fenômeno de não Refluxo/terapia , Encéfalo , Resultado do Tratamento , Acidente Vascular Cerebral/tratamento farmacológico
16.
Sci Bull (Beijing) ; 67(2): 125-132, 2022 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36546005

RESUMO

The 25Mg(p, γ)26Al reaction plays an important role in the study of cosmic 1.809 MeV γ-ray as a signature of ongoing nucleosynthesis in the Galaxy. At astrophysical temperature around 0.1 GK, the 25Mg(p, γ)26Al reaction rates are dominated by the 92 keV resonance capture process. We report a precise measurement of the 92 keV 25Mg(p, γ)26Al resonance in the day-one experiment at Jinping Underground Nuclear Astrophysics experiment (JUNA) facility in the China Jinping Underground Laboratory (CJPL). The resonance strength and ground state feeding factor are determined to be 3.8±0.3 ×10-10 eV and 0.66±0.04, respectively. The results are in agreement with those reported in the previous direct underground measurement within uncertainty, but with significantly reduced uncertainties. Consequently, we recommend new 25Mg(p, γ)26Al reaction rates which are by a factor of 2.4 larger than those adopted in REACLIB database at the temperature around 0.1 GK. The new results indicate higher production rates of 26gAl and the cosmic 1.809 MeV γ-ray. The implication of the new rates for the understanding of other astrophysical situations is also discussed.

17.
Polymers (Basel) ; 14(21)2022 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-36365488

RESUMO

Lithium metal batteries are emerging as the next generation of high-density electrochemical energy storage systems because of the ultra-high specific capacity and ultra-low electrochemical potential of the Li metal anode. However, the uneven Li deposition on commercial Cu current collectors result in low Coulombic efficiencies (CEs) and poor cycle life. In this research, we proposed the modification of ZnFx(OH)y on Cu foils to expand the lifespan. As-generated ZnLi alloy and LiF could promote uniform Li nucleation and deposition, thus resulting in an improved Li plating/stripping CE and extended cycle life. The Li-S battery with sulfurized polyacrylonitrile cathode and Li-ZnFx(OH)y@Cu anode (N/P ratio of 1.5:1) maintains 95% capacity after 60 cycles, proving the feasibility of ZnFx(OH)y@Cu for practical applications.

18.
BMC Neurol ; 22(1): 327, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36050644

RESUMO

BACKGROUND: ß2-microglobulin has been showing to be vital that associated with brain function and neurological diseases. This study aimed to explore the expressions of ß2-microglobulin in blood and urine of the patients with brain injury, and the effect of hyperbaric oxygen therapy on the content of ß2-microglobulin. METHODS: This prospective study included 54 patients with brain injury and 11 healthy controls. The patients were further assigned to two groups: the conscious disturbance group (n = 32) and the non-conscious disturbance group (n = 22) depending on the Glasgow Coma Scale (GCS). The patients received routine treatment and two courses of hyperbaric oxygen therapy (2.0ATA, 60 min, once a day, 10 days for a course). In the brain injury group, blood ß2-microglobulin (ß2MG) and urine ß2-microglobulin (ß2MU) were detected respectively before and after hyperbaric oxygen therapy (HBOT). Consciousness and cognitive scores were performed, correspondingly. RESULTS: Compared with those of the control group, levels of ß2MG and ß2MU in the brain injury group were significantly increased before HBOT (P < 0.05). Whether it was before or after HBOT, ß2MG's content in the conscious disturbance group was higher than that in the non-conscious disturbance group, while ß2MU's content was obviously higher than that of the non-conscious disturbance group only before HBOT (P < 0.05). Besides, the ß2MU's content in the conscious disturbance group was negatively correlated with GCS score (R = -0.351, P < 0.05) and ß2MG's content in the non-conscious disturbance group was positively correlated with the MMSE score grade (R = 0.598, P < 0.05). The ROC curve was used to assess the evaluation of ß2MG and ß2MU for patients with impaired consciousness with the area under the curve (AUC) of ß2MG and ß2MU were 0.775 and 0.796, respectively. CONCLUSION: The concentrations of blood ß2-microglobulin and urinary ß2-microglobulin were significantly increased in patients with brain injury. The concentrations of ß2-microglobulin were correlated with the degree of consciousness and cognitive function. The changes tendency of ß2-microglobulin may be considered as clinical monitoring index to evaluate the patient's disturbance of consciousness and cognitive degree, and provide a basis for early assessment of prognosis.


Assuntos
Lesões Encefálicas , Lesões Encefálicas/diagnóstico , Lesões Encefálicas/terapia , Escala de Coma de Glasgow , Humanos , Prognóstico , Estudos Prospectivos , Curva ROC , Microglobulina beta-2
19.
Polymers (Basel) ; 14(17)2022 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-36080527

RESUMO

Lithium metal batteries (LMBs) are promising next-generation battery technologies with high energy densities. However, lithium dendrite growth during charge/discharge results in severe safety issues and poor cycling performance, which hinders their wide applications. The rational design and application of functional polymer materials in LMBs are of crucial importance to boost their electrochemical performances, especially the cycling stability. In this review, recent advances of advanced polymer materials are examined for boosting the stability and cycle life of LMBs as different components including artificial solid electrolyte interface (SEI) and functional interlayers between the separator and lithium metal anode. Thereafter, the research progress in the design of advanced polymer electrolytes will be analyzed for LMBs. At last, the major challenges and key perspectives will be discussed for the future development of functional polymers in LMBs.

20.
Polymers (Basel) ; 14(16)2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-36015568

RESUMO

Lithium-metal batteries have attracted extensive research attention because of their high energy densities. Developing appropriate electrolytes compatible with lithium-metal anodes is of great significance to facilitate their practical application. Currently used electrolytes still face challenges of high production costs and unsatisfactory Coulombic efficiencies of lithium plating/stripping. In this research, we have developed a diluted electrolyte which is compatible with both lithium-metal anode and sulfurized polyacrylonitrile cathode. It presents a very high Li plating/stripping Coulombic efficiency of 99.3% over prolonged cycling, and the as-assembled anode-free Li-S battery maintains 71.5% of the initial specific capacity after 200 cycles at 0.1 A g-1. This work could shed light on designing a low-cost and high-performance liquid electrolyte for next-generation high-energy batteries.

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