Theoretical study of a new molecular ion species BeN+: molecular states and cross sections for electronic excitation and dissociation.

We present here a theoretical study of a new molecular ion species BeN+, which has not been reported before. Using a good quality configuration interaction model, we first undertake a configuration interaction calculation of the molecular states to obtain the potential energy curves of several low lying states of BeN+ and the dipole and transition dipole moments of some of its states as a function of the internuclear distance. We find the ground state to be bound and of X 3Σ- character having a shallow minimum at Re = 2.9031a0 and several other closely spaced excited states some of which are repulsive. We have determined the spectroscopic parameters for some of these states by fitting the raw potential energy data to a 6-parameter analytical potential energy function. Subsequently, the R-matrix method is used to obtain electron collision cross sections for electronic excitation from the ground X 3Σ- state to several of its excited states at the equilibrium Re = 2.9031a0 and cross sections for electron impact dissociation. We have also reported many Feshbach resonances and their widths at the equilibrium Re = 2.9031a0, which may, in future studies, be extended to potential energy curves for neutral dissociative states. The states and cross sections obtained are of considerable significance for edge plasma chemistry in fusion devices operating with beryllium walls.

The role of ncRNA in the co-regulation of autophagy and exosome pathways during cancer progression.

Since its discovery a few decades ago, autophagy has been recognized as a crucial signaling pathway, linked to the recycling of cellular components in nutrient stress. Autophagy is a two-way sword, playing a dual role in tumorigenesis. In this catabolic process, dysfunctional organelles, biomolecules, and misfolded proteins are sequestered in the autophagosome and sent to the lysosome for degradation. Alongside, there are cellular messengers called exosomes, which are released from cells and are known to communicate and regulate metabolism in recipient cells. Multivesicular bodies (MVB) act as the intricate link between autophagy and exosome pathways. The continuous crosstalk between the two pathways is coordinated and regulated by multiple players among which ncRNA is the emerging candidates. The exosomes carry varied cargo of which non-coding RNA exerts an immediate regulatory effect on recipient cells. ncRNA is known to exhibit dual behavior in both promoting and inhibiting tumor growth. There is increasing evidence for the involvement of ncRNAs' in the regulation of different hallmarks of cancer. Different ncRNAs are involved in the co-regulation of autophagy and exosome pathways and therefore represent a superior therapeutic approach to target cancer chemoresistance. Here, we will discuss the ncRNA involved in regulating autophagy, and exosomes pathways and its relevance in cancer therapeutics.

Reliability and clinical utility of the chronic pain classification in the 11th Revision of the International Classification of Diseases from a global perspective: results from India, Cuba, and New Zealand.

ABSTRACT: Chronic pain affects 1 in 5 persons and contributes substantially to the global burden of disease. The 11th Revision of the International Classification of Diseases (ICD-11) includes a comprehensive classification of chronic pain. The aim of this ecological implementation field study was to evaluate the classification's interrater reliability and clinical utility in countries with different income levels. The study was conducted in 4 pain clinics in Cuba, India, and New Zealand. Twenty-one clinicians used the ICD-11 to diagnose and code n = 353 patients with chronic pain. Of these, 111 were assessed by 2 clinicians, and Fleiss' kappa was calculated to establish interrater reliability for any diagnosis assigned to ≥15 patients. The clinicians rated the clinical utility of all diagnoses. The interrater reliability could be calculated for 11 diagnoses. It was substantial for 10 diagnoses and moderate for 1 (kappa: 0.596-0.783). The mean clinical utility of the ICD-11 chronic pain diagnoses was rated as 8.45 ± 1.69/10. Clinical utility was rated higher for ICD-11 than for the commonly used classification systems (P < 0.001, η2 = 0.25) and differed between all centers (P < 0.001, η2 = 0.60). The utility of the ICD-11 diagnoses was rated higher than the commonly used diagnoses in Dunedin and Havana, and no difference was found in Kolkata and Hyderabad. The study showed the high interrater reliability of the new chronic pain diagnoses. The perceived clinical utility of the diagnoses indicates their superiority or equality compared with the classification systems currently used in pain clinics. These results suggest the global applicability of the classification in specialized pain treatment settings.