RESUMO
This retrospective review of hospital records analysed pregnancy outcome with 2 different treatments for women with recurrent miscarriage diagnosed with antiphospholipid syndrome in the index pregnancy. Of 64 women, 29 had received aspirin and 35 aspirin plus heparin. Pregnancy-induced hypertension, prematurity, intrauterine growth restriction and neonatal death were considered as maternal and fetal complications. There were no significant differences in antenatal and maternal complications between the groups. HOwever, there were significant differences in mean anticardiolipin IgG antibody levels. Aspirin alone or in combination with parin was equally efficacious in women with antiphospholipid syndrome and recurrent miscarriage.
Assuntos
Síndrome Antifosfolipídica/tratamento farmacológico , Aspirina/uso terapêutico , Fibrinolíticos/uso terapêutico , Heparina/uso terapêutico , Complicações na Gravidez/tratamento farmacológico , Resultado da Gravidez/epidemiologia , Adulto , Anticorpos Anticardiolipina/sangue , Anticorpos Anticardiolipina/efeitos dos fármacos , Síndrome Antifosfolipídica/sangue , Síndrome Antifosfolipídica/complicações , Síndrome Antifosfolipídica/imunologia , Aspirina/farmacologia , Distribuição de Qui-Quadrado , Quimioterapia Combinada , Feminino , Fibrinolíticos/farmacologia , Heparina/farmacologia , Humanos , Imunoglobulina G/sangue , Imunoglobulina G/efeitos dos fármacos , Imunoglobulina M/sangue , Imunoglobulina M/efeitos dos fármacos , Paquistão/epidemiologia , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/imunologia , Estudos Retrospectivos , Resultado do TratamentoAssuntos
Ascite/complicações , Endometriose/complicações , Infecções por Escherichia coli/complicações , Cistos Ovarianos/complicações , Derrame Pleural/complicações , Adulto , Ascite/patologia , Ascite/cirurgia , Endometriose/patologia , Endometriose/cirurgia , Infecções por Escherichia coli/patologia , Infecções por Escherichia coli/cirurgia , Feminino , Humanos , Cistos Ovarianos/patologia , Cistos Ovarianos/cirurgia , Derrame Pleural/patologia , Derrame Pleural/cirurgiaRESUMO
Intracellular free calcium is regulated by Ca(++)-ATPase, one form present on the plasma membrane (PM Ca(++)-ATPase) and the other on sarcoplasmic (endoplasmic) reticulum (SR/ER Ca(++)-ATPase). An endogenous inhibitor of SR Ca(++)-ATPase from human placenta was shown to be present in normal placenta and the activity was not detectable in placenta from preeclamptic patients. The inhibitor was distributed in cytosol and microsomes. The inhibition of Ca(++)-ATPase by this inhibitor was concentration- and time-dependent. The inhibitor neither bound to DEAE- nor CM-sepharose resins at pH 7.5 and 8.5. Furthermore, it was heat stable for 15 min up to 55 degrees C and completely destroyed at 80 degrees C in a few minutes. It was also observed to be stable at room temperature for at least 3 months. The purification and characterization of this inhibitor would be valuable in achieving an understanding of the normal regulation of Ca(++)-ATPase in the placenta during pregnancy.
Assuntos
ATPases Transportadoras de Cálcio/antagonistas & inibidores , Inibidores Enzimáticos/metabolismo , Placenta/metabolismo , Animais , Citosol/metabolismo , Feminino , Humanos , Microssomos/metabolismo , Gravidez , Coelhos , TemperaturaRESUMO
This is a retrospective case control study. Out of a total of 1238 births occurring over a period of 8 months at the Aga Khan University Medical Centre, Karachi, 9.4% were preterm. Factors found to be associated with preterm labour were age > 35, height < 156 cm, anaemia or urinary tract infection in pregnancy, abruptio placentae, polyhydramnios, preterm rupture of membranes, intrauterine growth retardation, fetal distress and intrauterine death. Previous bad obstetric history was also relevant. A preterm baby was found to be at higher risk of postnatal complications resulting in neonatal death or admission to the Neonatal Intensive Care Unit (NICU) than a full term baby.