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1.
Hum Fertil (Camb) ; 26(3): 622-631, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34753367

RESUMO

This review explores the challenges in the diagnosis of hypogonadotropic hypogonadism, the transition of care from paediatric to adult care and the considerable health implications of this condition. The role gynaecologists and general practitioners have in managing hormone replacement therapy and reproductive potential is also highlighted. The fertility treatment options, which include ovulation induction with gonadotrophins and in-vitro fertilisation, are discussed in detail along with highlighting the fact that anovulation and markers of low ovarian reserve prior to priming treatment may not be reflective of poor reproductive potential. The holistic management of women with hypogonadotropic hypogonadism is still not standardised and evidence for subfertility management is scarce. This review aims to highlight this concern and provide guidance by evaluating current evidence.


Assuntos
Hipogonadismo , Infertilidade , Transição para Assistência do Adulto , Adulto , Feminino , Humanos , Criança , Hipogonadismo/tratamento farmacológico , Gonadotropinas/uso terapêutico , Fertilidade
2.
Food Chem Toxicol ; 154: 112312, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34102214

RESUMO

Malachite green (MG) is extensively applied in aquaculture worldwide as a therapeutic agent. MG and its primary metabolite leucomalachite green (LMG) are commonly detected in aquaculture products. MG can cause serious health concerns (in vivo carcinogenic/genotoxic). The extensive water solubility of MG leads to water pollution and hence it is mandatory to remove MG from water. The current study explores adsorptive removal of MG from water using highly water stable Zeolitic Imidazolate framework/graphene oxide composites (ZIF-67@GO). Adsorption performance of newly synthesized composites is justified for MG removal with excellent results of pseudo second order (R2 = 0.99955) which is well-fitted in this case. ZIF-67@GO data of adsorption isotherm for MG is observed using Freundlich Model (R2 = 0.99999) and with adsorption capacity value observed (134.79 mg/g) with removal efficiency of 99.18%, indicates π-staking and electrostatic association between ZIF-67@GO and MG molecules. Synthesized material has retained reusability while removal efficiency reduced only by 6% after many cycles. Furthermore, factors effecting absorption like contact time, pH, adsorbent dose and quantity and temperature are also determined.


Assuntos
Grafite/química , Imidazóis/química , Estruturas Metalorgânicas/química , Corantes de Rosanilina/isolamento & purificação , Poluentes Químicos da Água/isolamento & purificação , Zeolitas/química , Adsorção , Concentração de Íons de Hidrogênio , Cinética , Microscopia Eletrônica de Varredura , Espectroscopia de Infravermelho com Transformada de Fourier , Eletricidade Estática , Temperatura , Termodinâmica
3.
Food Chem Toxicol ; 149: 112008, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33508417

RESUMO

Heavy metals especially lead (Pb) and mercury (Hg) are recognized as most emerging pollutants in underground water and are major threat to public health around the world. Major challenge to mitigate water pollution is construction of effective materials containing a host of deceivingly accessible high-density and high-level efficiency. Herein, we have synthesized two metal-organic frameworks (MOFs) with efficient porosity showing the right combination of structures. Representatively, ZIF-8 and ZIF-67 were designed by reacting Zn, Co salts with 2-methyl imidazole showing superior efficacy in removing Pb and Hg (1978.63&1436.11 mg/g respectively) from water. These adsorbents displayed high distribution values permitting them to quickly reduce concentration level of Pb2+, Hg2+ below permissible limit (Pb = 0-15 µg/L, Hg = 1-10 µg/L). EDX, FTIR analysis revealed that Pb2+, Hg2+ bound through weak interactions. Results presented here have shown extraordinary potential with high environmental remediation performance having 99.5% and 98.1% removal efficiency for lead & mercury respectively. Results revealed that adsorbents have same organic linker that identifies same morphology required for adsorption. The difference in adsorption capacity and porosity (ZIF-8 = 937&1370 m2/g, ZIF-67 = 1289&1889 m2/g) are deliberately caused due to presence of metal atoms having different electronic distribution, as cobalt in ZIF-67 and in case of ZIF-8 zinc metal.


Assuntos
Imidazóis/química , Chumbo/química , Mercúrio/química , Estruturas Metalorgânicas/química , Poluentes Químicos da Água/química , Água/química , Adsorção , Cinética , Microscopia Eletrônica de Varredura , Purificação da Água
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