The protective effects of quercetin on the physiological responses in malathion-exposed common carp, Cyprinus carpio.

This study aimed to evaluate the protective effects of quercetin on the biochemical parameters, immunity, and growth performance in malathion-exposed common carp, Cyprinus carpio. The methods six experimental groups, including the control group, fish exposed to concentrations of 1.04 and 2.08 mg/l malathion, fish supplemented with quercetin (200 mg/kg diet), and fish treated with quercetin + malathion for 21 days, were considered for the experiment. After the feeding period, in results the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) were significantly decreased in the hepatocyte, while malondialdehyde (MDA) content increased in response to malathion. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and glucose, cortisol, and urea levels significantly increased after exposure to malathion. Exposure of fish to malathion-induced decreases in protease, lysozyme, and alternative complement (ACH50) activities and total immunoglobulin (total Ig) in the mucosa. Changes in other parameters were different depending on malathion concentrations. The supplementation of fish with quercetin had no ameliorating effect on the malathion-related alternations of mucosal lysozyme and protease activities. However, quercetin ameliorated the depressing effects of malathion on biochemical and immunological parameters. Changes in the growth performance and hematological parameters indicated the toxic effect of malathion. In conclusion, quercetin could efficiently reduce the toxic effects of malathion on the biochemical, immune, and hematological parameters of the common carp.

Effectiveness of Self-concept Management of Patients with Depression in Diabetic Ulcer.

BACKGROUND: This study explores the management of self-concept in improving the quality of life of diabetic ulcer patients. Low confidence in the quality of life is a factor causing patients with long-term diabetes to believe they cannot be cured properly. Ulcers result from diabetes mellitus complications due to the nervous system and blood vessel damage. Patients with diabetic ulcers experience depression and feel acute stress when the disease has been categorized as a chronic condition. METHODS: This study uses quantitative methods with a cross-sectional study design approach. The data collection techniques used purposive sampling and had 82 diabetic ulcer sufferers as respondents in the study. RESULTS: This study empirically proves that (p-value ≤ α=0.05) where there is effective management of the concept of self-health applied by diabetic ulcer patients in reducing the level of depression and sufferers can increase their confidence in better health factors. CONCLUSION: The effectiveness of self-care management is an important indicator in overcoming diabetic ulcer disease. The low management of self-concept for people with diabetes will certainly impact increasing depression and acute stress, decreasing the quality of life for sufferers.

The Comparative Effects of Teacher Versus Peer-Scaffolding on EFL Learners' Incidental Vocabulary Learning and Reading Comprehension: A Socio-Cultural Perspective.

Drawing on sociocultural theory, and multiple empirical studies conducted on the effectiveness of scaffolding on second or foreign language learning, the authors investigated the application of various forms of scaffolding (i.e., teacher versus peer-scaffolding) on EFL learners' incidental vocabulary learning and reading comprehension performance through a sociocultural perspective. To this end, 60 EFL learners out of one-hundred were selected through the administration of an Oxford Placement Test from three language institutes and divided into 3 groups (two experimental and one control group) each including 20 intermediate EFL learners. The first experimental group received teacher-scaffolding instruction, the second experimental group received peer-scaffolding instruction and the control group received traditional instruction with no scaffolding. The vocabulary and reading comprehension pre-tests were administered to the three groups. At the end of the experiment, the vocabulary and reading comprehension post-tests were administered. The descriptive statistics (mean and standard deviation) and the inferential statistics (a One-way ANOVA) were run to analyze the collected data. The results showed that both experimental groups had better performance than the control group and there was a significant difference between teacher-scaffolding and peer-scaffolding in both vocabulary knowledge and reading comprehension performance and the peer-scaffolding group had a better performance than the teacher-scaffolding group. This research provided some implications about different types of scaffolding for language teachers and syllabus designers.

Prevalence of the Effects of Anxiety and Depression on People with Type 2 Diabetes Mellitus: An Analysis of Health Policy Studies in Improving the Quality of Life of Poor Families in the Urban Areas of West Lombok, Indonesia.

BACKGROUND: To explore the tendency of the effects of anxiety and depression that occur in type 2 diabetes patients, especially poor patients who live in the urban areas with poor economic conditions, who do not have health access from the government, and live away from the hospitals. METHODS: It is a cross-sectional study which aimed to determine the number of patients who experienced anxiety and depression problems due to the declining health conditions caused by diabetes. A sample size of 98 diabetics experiencing anxiety and depression when the treatment was carried out was included. The study design included a qualitative study with in-depth interviews with respondents who were at risk of diabetes, as well as to determine the level of anxiety and depression that occurred when medical care was provided and the feelings experienced by the respondents after the completion of treatment. RESULTS: Diabetic patients are generally unaware that their illness is a chronic disease that takes a long time to treat. When the patients are sick, most of them do not immediately go to the hospital or a specialist to get their health examination and treatment, because the hospital is far from the patients' residence. Furthermore, some patients still use traditional medicine and non-medical treatment, so when the patients with critical conditions are taken to the hospital, they already have chronic diabetes. CONCLUSION: The lack of access to health for chronic patients with poor economic conditions who live far from the hospitals and the scarcity of medical staff to carry out treatment of chronic diseases such as diabetes for poor patients in urban areas certainly have an impact on increasing the number of patients with chronic diseases. Therefore, the government is expected to be able to provide easy health policies to remote rural communities in order to achieve optimal community welfare and health.