RESUMO
Active oxygen species are produced as a consequence of normal aerobic metabolism. Of these, free radicals are usually metabolized or inactivated in vivo by a team of antioxidants. Individual members are a trained team fighting antioxidants to prevent the generation of ROS, destroy or oxidizing potential of capture. In terms of physiological oxidative stress, induced tissue attack is minimal. A relative or absolute deficiency in the antioxidant defense may lead to increased oxidative stress and this event is associated with both the causes and consequences of diseases and cancer, included here. The aim of the study is to identify the role of antioxidant defense systems and the reduction of oxidative stress in dynamic growth and development of malignant tumors. Our in vivo study was developed and referred to carcinosarcoma carriers Wistar rats treated with non-enzymatic antioxidants: vitamin C, vitamin A, zinc salt (II), and arginine in various combinations. Treatment was initiated three weeks before tumor induction.
Assuntos
Antioxidantes/farmacologia , Neoplasias/patologia , Estresse Oxidativo/efeitos dos fármacos , Animais , Proliferação de Células/efeitos dos fármacos , Modelos Animais de Doenças , Ferro/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Oxirredução , Ratos , Ratos Wistar , Espécies Reativas de Oxigênio/metabolismo , Compostos de Sulfidrila/metabolismoRESUMO
In 1994 Butov et al. [Phys. Rev. Lett. 73, 304 (1994)] reported large, extremely low-frequency fluctuations in the luminescence intensity from indirect excitons in a coupled quantum well. We have reproduced these fluctuations in a similar structure. Our observations indicate, however, that the fluctuations are spectral fluctuations rather than intensity fluctuations. We have eliminated several possible causes for the fluctuations and propose a possible cause.