Assuntos
Caderinas/genética , Predisposição Genética para Doença/genética , Mutação em Linhagem Germinativa , Neoplasias Gástricas/genética , Proteína Supressora de Tumor p53/genética , Animais , Células CHO , Subunidade alfa 3 de Fator de Ligação ao Core , Cricetinae , Cricetulus , DNA/química , DNA/genética , Análise Mutacional de DNA/métodos , Proteínas de Ligação a DNA/genética , Saúde da Família , Feminino , Humanos , Imuno-Histoquímica , Masculino , Proteínas de Membrana/genética , Proteínas de Neoplasias/genética , Linhagem , Neoplasias Gástricas/patologia , Fatores de Transcrição/genética , Proteína Supressora de Tumor p53/análiseRESUMO
BACKGROUND: Patients on renal replacement therapy, haemodialysis (HD), or after kidney transplantation (TX), are known to be at risk of acquiring blood-borne infections (HBV, HCV). GBV-C/Hepatitis G virus (HGV) has been described recently and is considered to cause blood-borne infections. The aim of this study was to analyse the risk for the medical staff of HD and TX patients to acquire HGV infection. METHODS: Eighty-five HD patients and 86 TX recipients were compared with 49 health-care workers and 64 blood donors as controls. The HGV prevalence was determined by RT-PCR and antibodies to E2 protein. RESULTS: A high prevalence of HGV was found in the medical staff (24%) which nearly corresponded to the prevalence of the patients (TX 36%, HD 25%) but not to the controls (9%). In contrast, the prevalence of HCV was low in the medical staff (2%) and controls (0%) but high in HD (13%) and TX (13%). Age and duration of employment in the department did not significantly influence the HGV prevalence in staff. The number of viraemic subjects in staff was high, possibly indicating a more recent infection. CONCLUSION: An occupational risk for HGV exists in medical staff of dialysis and transplant patients. Further routes of transmission than only parenteral may play a role in this setting.