A contemporary review of breast cancer risk factors and the role of artificial intelligence.

Background: Breast cancer continues to be a significant global health issue, necessitating advancements in prevention and early detection strategies. This review aims to assess and synthesize research conducted from 2020 to the present, focusing on breast cancer risk factors, including genetic, lifestyle, and environmental aspects, as well as the innovative role of artificial intelligence (AI) in prediction and diagnostics. Methods: A comprehensive literature search, covering studies from 2020 to the present, was conducted to evaluate the diversity of breast cancer risk factors and the latest advances in Artificial Intelligence (AI) in this field. The review prioritized high-quality peer-reviewed research articles and meta-analyses. Results: Our analysis reveals a complex interplay of genetic, lifestyle, and environmental risk factors for breast cancer, with significant variability across different populations. Furthermore, AI has emerged as a promising tool in enhancing the accuracy of breast cancer risk prediction and the personalization of prevention strategies. Conclusion: The review highlights the necessity for personalized breast cancer prevention and detection approaches that account for individual risk factor profiles. It underscores the potential of AI to revolutionize these strategies, offering clear recommendations for future research directions and clinical practice improvements.

Predicting Cardiovascular Rehabilitation of Patients with Coronary Artery Disease Using Transfer Feature Learning.

Cardiovascular diseases represent the leading cause of death worldwide. Thus, cardiovascular rehabilitation programs are crucial to mitigate the deaths caused by this condition each year, mainly in patients with coronary artery disease. COVID-19 was not only a challenge in this area but also an opportunity to open remote or hybrid versions of these programs, potentially reducing the number of patients who leave rehabilitation programs due to geographical/time barriers. This paper presents a method for building a cardiovascular rehabilitation prediction model using retrospective and prospective data with different features using stacked machine learning, transfer feature learning, and the joint distribution adaptation tool to address this problem. We illustrate the method over a Chilean rehabilitation center, where the prediction performance results obtained for 10-fold cross-validation achieved error levels with an NMSE of 0.03±0.013 and an R2 of 63±19%, where the best-achieved performance was an error level with a normalized mean squared error of 0.008 and an R2 up to 92%. The results are encouraging for remote cardiovascular rehabilitation programs because these models could support the prioritization of remote patients needing more help to succeed in the current rehabilitation phase.

Outlier Vehicle Trajectory Detection Using Deep Autoencoders in Santiago, Chile.

In the last decade, a large amount of data from vehicle location sensors has been generated due to the massification of GPS systems to track them. This is because these sensors usually include multiple variables such as position, speed, angular position of the vehicle, etc., and, furthermore, they are also usually recorded in very short time intervals. On the other hand, routes are often generated so that they do not correspond to reality, due to artifacts such as buildings, bridges, or sensor failures and where, due to the large amount of data, visual analysis of human expert is unable to detect genuinely anomalous routes. The presence of such abnormalities can lead to faulty sensors being detected which may allow sensor replacement to reliably track the vehicle. However, given the reliability of the available sensors, there are very few examples of such anomalies, which can make it difficult to apply supervised learning techniques. In this work we propose the use of unsupervised deep neural network models based on stacked autoencoders to detect anomalous routes in vehicles within Santiago de Chile. The results show that the proposed model is capable of effectively detecting anomalous paths in real data considering validation given by an expert user, reaching a performance of 82.1% on average. As future work, we propose to incorporate the use of Long Short-Term Memory (LSTM) and attention-based networks in order to improve the detection of anomalous trajectories.

Co-Training for Visual Object Recognition Based on Self-Supervised Models Using a Cross-Entropy Regularization.

Automatic recognition of visual objects using a deep learning approach has been successfully applied to multiple areas. However, deep learning techniques require a large amount of labeled data, which is usually expensive to obtain. An alternative is to use semi-supervised models, such as co-training, where multiple complementary views are combined using a small amount of labeled data. A simple way to associate views to visual objects is through the application of a degree of rotation or a type of filter. In this work, we propose a co-training model for visual object recognition using deep neural networks by adding layers of self-supervised neural networks as intermediate inputs to the views, where the views are diversified through the cross-entropy regularization of their outputs. Since the model merges the concepts of co-training and self-supervised learning by considering the differentiation of outputs, we called it Differential Self-Supervised Co-Training (DSSCo-Training). This paper presents some experiments using the DSSCo-Training model to well-known image datasets such as MNIST, CIFAR-100, and SVHN. The results indicate that the proposed model is competitive with the state-of-art models and shows an average relative improvement of 5% in accuracy for several datasets, despite its greater simplicity with respect to more recent approaches.

Wavelet-Based Entropy Measures to Characterize Two-Dimensional Fractional Brownian Fields.

The aim of this work was to extend the results of Perez et al. (Physica A (2006), 365 (2), 282-288) to the two-dimensional (2D) fractional Brownian field. In particular, we defined Shannon entropy using the wavelet spectrum from which the Hurst exponent is estimated by the regression of the logarithm of the square coefficients over the levels of resolutions. Using the same methodology. we also defined two other entropies in 2D: Tsallis and the Rényi entropies. A simulation study was performed for showing the ability of the method to characterize 2D (in this case, α = 2 ) self-similar processes.

Fractal and stochastic geometry inference for breast cancer: a case study with random fractal models and Quermass-interaction process.

Fractals are models of natural processes with many applications in medicine. The recent studies in medicine show that fractals can be applied for cancer detection and the description of pathological architecture of tumors. This fact is not surprising, as due to the irregular structure, cancerous cells can be interpreted as fractals. Inspired by Sierpinski carpet, we introduce a flexible parametric model of random carpets. Randomization is introduced by usage of binomial random variables. We provide an algorithm for estimation of parameters of the model and illustrate theoretical and practical issues in generation of Sierpinski gaskets and Hausdorff measure calculations. Stochastic geometry models can also serve as models for binary cancer images. Recently, a Boolean model was applied on the 200 images of mammary cancer tissue and 200 images of mastopathic tissue. Here, we describe the Quermass-interaction process, which can handle much more variations in the cancer data, and we apply it to the images. It was found out that mastopathic tissue deviates significantly stronger from Quermass-interaction process, which describes interactions among particles, than mammary cancer tissue does. The Quermass-interaction process serves as a model describing the tissue, which structure is broken to a certain level. However, random fractal model fits well for mastopathic tissue. We provide a novel discrimination method between mastopathic and mammary cancer tissue on the basis of complex wavelet-based self-similarity measure with classification rates more than 80%. Such similarity measure relates to Hurst exponent and fractional Brownian motions. The R package FractalParameterEstimation is developed and introduced in the paper.

Image denoising with 2D scale-mixing complex wavelet transforms.

This paper introduces an image denoising procedure based on a 2D scale-mixing complex-valued wavelet transform. Both the minimal (unitary) and redundant (maximum overlap) versions of the transform are used. The covariance structure of white noise in wavelet domain is established. Estimation is performed via empirical Bayesian techniques, including versions that preserve the phase of the complex-valued wavelet coefficients and those that do not. The new procedure exhibits excellent quantitative and visual performance, which is demonstrated by simulation on standard test images.