RESUMO
Biochemical methods confirmed the presence of the heparin-ATP complex. Acid sulfonate and carboxyl groups proved to mediate heparin-ATP complex formation. The technique for preparation of the heparin complex at a 1 : 20 weight ratio of the components and different pH was developed. Intramuscular administration of resulting complex increased anticoagulant and fibrinolytic activities of animal (rat) plasma. The obtained data indicate the presence of physiologically active heparin-ATP complex providing for anticoagulant effects in the body.
Assuntos
Trifosfato de Adenosina/farmacologia , Anticoagulantes/isolamento & purificação , Anticoagulantes/farmacologia , Coagulação Sanguínea/efeitos dos fármacos , Heparina/farmacologia , Animais , Anticoagulantes/administração & dosagem , Concentração de Íons de Hidrogênio , Injeções Intramusculares , Masculino , RatosRESUMO
A soft synthetic semi-ring was used in reconstructive-plastic operations on 36 patients with rheumatic mitral insufficiency; it was sutured in the projection of the posterior cusp. The operative techniques and the immediate results are described. Lethality was 5.5%.