[The elimination of disorders in the acquisition of a conditioned active avoidance reaction by using the C-termination fragment of lysyl vasopressin]. / Ustranenie narushenii vyrabotki uslovnoi reaktsii aktivnogo izbeganiia C-kontsevym fragmentom lizilvazopressina.

In experiments with male white rats it was shown that 0.001 and 0.01 mg/kg of lysyl vasopressin C-terminal fragment--Pro-Lys-Gly (PLG) being injected intraperitoneally fails to influence the acquisition of active and passive avoidance and also T-maze food rewarded behaviour. The injection of PLG removed by disturbances of active avoidance caused by cyproheptadine and oxytocin. The inhibition of passive avoidance and food-rewarded behaviour was not removed by PLG.

[Evaluation of the effect of arginine vasopressin on the formation of the conditioned reaction of active avoidance in rats]. / Otsenka deistviia arginil-vazopressina na formirovanie uslovnoi reaktsii aktivnogo izbeganiia u krys.

The effect was studied of arginine-vasopressin (AVP) intraperitoneal administration in a doze of 0.001 mg/kg on elaboration of conditioned reaction (CR) of active avoidance in rats. Estimation of reaction dynamics by dynamic delta index allowed to increase the informational value of the experimental data with taking into account the direction of reaction shift and individual characteristic of the animal. AVP improved the elaboration of active avoidance CR, lowered variability of individual learning ability and did not influence the change of the number of intersignal reactions and short-latency escapes in the process of learning. It is suggested that the main site of AVP effect is the animal's reaction to conditioned sound stimulus.

[Effect of hormones of the neurohypophysis on different types of behavioral responses in the rat]. / Deistvie gormonov neirogipofiza na razlichnye tipy povedencheskikh reaktsii u krys.

In experiments on male rats arginyl-vasopressin (AVP), lysyl-vasopressin (LVP) and vasotocin (VT) in doses of 0.005-0.010 mg/kg decreased motor activity and emotional behaviour in the open field test. In a dose of 0.001 mg/kg AVP significantly accelerated the elaboration of active avoidance; oxytocin delayed it, but LVP and VT had no significant influence. AVP also somewhat attenuated the elaboration of passive avoidance. None of the four studied peptides significantly affected the rate of elaboration of conditioned food-rewarded reaction to place.