RESUMO
An 18-year-old female patient was referred with complaints of tearing and redness in the left eye for 3 months after a mild ocular trauma with a turkey feather. She was treated with topical antibiotics and corticosteroids with no improvement. Slit-lamp examination of the left eye showed a vascularized lesion with a polypoidal appearance due to multiple contiguous micronodules on the temporal and inferior bulbar conjunctiva. Results of the anterior and posterior segment examination were unremarkable in both eyes. A biopsy specimen of the conjunctival mass showed multiple tuberculoid granulomas composed of epithelioid histiocytes with associated Langhan's type multinucleate giant cells and a necrotic nodule surrounded by histiocytes and giant cells. The Mantoux test was positive with induration of 15mm. The patient was prescribed antituberculosis therapy. Three months after treatment initiation, the conjunctival lesions had resolved. Mycobacterium tuberculosis should be considered in cases of unilateral chronic recalcitrant conjunctivitis. Biopsy of a conjunctival mass is of utmost importance to establish a definite diagnosis.
Assuntos
Doenças da Túnica Conjuntiva , Conjuntivite , Tuberculose Ocular , Feminino , Humanos , Adolescente , Tuberculose Ocular/complicações , Tuberculose Ocular/diagnóstico , Tuberculose Ocular/tratamento farmacológico , Conjuntivite/patologia , Granuloma/complicações , Granuloma/diagnóstico , Granuloma/patologia , Túnica Conjuntiva/patologia , Doenças da Túnica Conjuntiva/diagnóstico , Doenças da Túnica Conjuntiva/etiologia , Doenças da Túnica Conjuntiva/patologiaRESUMO
Metal-organic frameworks have shown interesting features for biomedical applications, such as drug delivery and imaging agents. The benchmarked mesoporous iron(III) trimesate MIL-100 MOF nanocarrier combines progressive release of high drug cargoes with absence of visible in vivo toxicity. Although in a previous study pharmacokinetics and biodistribution of MIL-100 nanoparticles were evaluated in the long term (from 24h to 1 month), the crucial times for drug targeting and delivery applications are shorter (up to 24h). Thus, this work aims to study the blood circulating profile and organ accumulation of MIL-100 nanocarrier at early times after administration. For this purpose, after intravenous administration to rats, both constitutive components of MIL-100 (trimesate and iron) were quantified by high performance liquid chromatography and a spectrophotometric method, respectively. The pharmacokinetic profile suggested that the nanoparticles act as a depot in the blood stream during the first hours before being cleared. Accumulation took mainly place in the liver and, in some extent, in the spleen. Nevertheless, histological studies demonstrated the absence of morphological alterations due to the presence of the particles in these organs. Liver function was however slightly altered as reflected by the increased plasma aspartate aminotransferase concentrations. Finally trimesate was progressively eliminated in urine.
Assuntos
Compostos de Ferro/administração & dosagem , Compostos de Ferro/metabolismo , Nanopartículas/administração & dosagem , Nanopartículas/metabolismo , Administração Intravenosa , Animais , Disponibilidade Biológica , Feminino , Ratos , Ratos Wistar , Fatores de TempoRESUMO
The aim of this paper is to report the autopsy findings of an Idiopathic Infantile Arterial Calcification-new-born male and describe its follow-up. Y.R, a 23-days-old male, hasn't any relevant personal past medical or family history. The baby was weighing 3.2 kg at birth. He was breast fed and appeared to be perfectly normal. In the last 24 hours, he presented to the family doctor with vomitis, refuse of feeds without fever or diarrhea. He was diagnosed as having gastroenteritis and was medicated accordingly. A few hours later, he had an hematemese episode associated with facial cyanosis. Death occurred despite cardio-pulmonary resuscitation. Forensic autopsy was required. The macroscopic examination showed a bilateral pleural liquid effusion without any other abnormalities. Microscopic investigation revealed a generalized arterial calcification of all organs. Idiopathic arterial calcification is primarily a disease of infancy. It is characterized pathologically by generalized arterial calcification within the internal elastic lamina, associated with intimal fibrous proliferation. Death occur often in the first sixth months due to heart failure.
Assuntos
Artérias/patologia , Calcificação Vascular/patologia , Autopsia , Biópsia , Causas de Morte , Evolução Fatal , Humanos , Recém-Nascido , MasculinoRESUMO
BACKGROUND: Acute localized exanthematous pustulosis (ALEP) is a rare and localized variant of acute generalized exanthematous pustulosis (AGEP). Only 15 cases of ALEP have been reported to date in the literature, with all cases following drug administration. We report 6 paediatric cases of ALEP occurring in springtime, with no associated drug administration in any case. PATIENTS AND METHODS: Over the last three years (2011, 2012 and 2013), we observed 6 cases of ALEP in 6 Tunisian children aged between 9 and 14 years. All cases were observed during the spring months. Diagnosis of ALEP was based in all cases on the EuroSCAR criteria and on the definition of ALEP proposed by Prange et al. A drug-related aetiology was ruled out in all cases, with exposure to a specific planned plant (Thapsia garganica) being retained as an aetiological factor in one case. DISCUSSION: Drug administration is the most frequent though not the sole cause of ALEP. The seasonal nature of this dermatosis may suggest other causes, mainly viral infection, plant contact or airborne allergens.
Assuntos
Pustulose Exantematosa Aguda Generalizada/diagnóstico , Dermatoses Faciais/diagnóstico , Pustulose Exantematosa Aguda Generalizada/tratamento farmacológico , Pustulose Exantematosa Aguda Generalizada/epidemiologia , Pustulose Exantematosa Aguda Generalizada/etiologia , Pustulose Exantematosa Aguda Generalizada/patologia , Adolescente , Corticosteroides/uso terapêutico , Antibacterianos/uso terapêutico , Biópsia , Criança , Dermatoses Faciais/tratamento farmacológico , Dermatoses Faciais/epidemiologia , Dermatoses Faciais/etiologia , Dermatoses Faciais/patologia , Feminino , Flores/efeitos adversos , Humanos , Leucócitos/patologia , Masculino , Estações do Ano , Thapsia/efeitos adversos , Tunísia/epidemiologiaAssuntos
Dermatoses Faciais/diagnóstico , Hiperpigmentação/diagnóstico , Ceratose Seborreica/diagnóstico , Acantólise , Idoso de 80 Anos ou mais , Biópsia , Carcinoma/diagnóstico , Diagnóstico Diferencial , Dermatoses Faciais/patologia , Dermatoses Faciais/cirurgia , Humanos , Hiperpigmentação/patologia , Ceratose Seborreica/patologia , Ceratose Seborreica/cirurgia , Masculino , Melanoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Verrugas/diagnósticoRESUMO
INTRODUCTION: Parathyroid carcinoma (PTC) is a rare parathyroid tumor. We report a case of PTC revealed by erythema nodosum (EN). CASE STUDY: A 53-year-old woman was admitted for EN exploration. Biology found hypercalcemia (3 mmol/L) and 184.89 ng/L parathormonemia. Histology following cervicotomy diagnosed PTC. Postoperative course was free of complications. At eight months' follow-up, there was no recurrence of EN. DISCUSSION/CONCLUSION: PCT is rare and life threatening. Paraneoplastic EN is rare, and has not previously been reported in association with PCT. Solid neoplasia and hemopathy should be systematically explored for in case of recurrent EN or resistance to conventional treatment.
Assuntos
Carcinoma/diagnóstico , Eritema Nodoso/etiologia , Síndromes Paraneoplásicas/etiologia , Neoplasias das Paratireoides/diagnóstico , Carcinoma/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Síndromes Paraneoplásicas/diagnóstico , Neoplasias das Paratireoides/cirurgiaRESUMO
Sacrococcygeal teratomas (SCT) are uncommon neonatal tumours which are usually benign. Our interest was aroused by encountering patients with reportedly benign SCT which later, after surgery, recurred as malignant tumours. We conducted a retrospective study of 17 patients treated for benign SCT during a period of 9 years. Of these patients, 4 developed malignant recurrence (3 females and 1 male) with a mean age of 19 months. The average time to recurrence was 17 months. Recurrence presented as a gluteal mass in one case, urinary and digestive compression signs in another case and as elevated alpha-fetoprotein levels in the two remaining cases. Histologically, one of the original tumors included tiny immature foci but none contained a malignant component after reading slides. Recurrences were as endodermal sinus tumour in all cases. After surgery and adjuvant chemotherapy, only one child died from complications related to chemotherapy. The other three were alive and well at mean follow-up of 5 years. These results emphasise the need for close clinical and biological follow-up for at least 2 years in all patients who had undergone excision of a neonatal SCT.
Assuntos
Tumor do Seio Endodérmico/patologia , Segunda Neoplasia Primária/patologia , Neoplasias da Coluna Vertebral/patologia , Teratoma/patologia , Tumor do Seio Endodérmico/terapia , Feminino , Humanos , Lactente , Masculino , Segunda Neoplasia Primária/terapia , Estudos Retrospectivos , Região Sacrococcígea , Neoplasias da Coluna Vertebral/terapiaRESUMO
We describe a case of a 55-year-old man who presented with pulmonary embolism and who was found to have nephrotic syndrome due to idiopathic membranous nephropathy. There are no other signs of nephrotic syndrome such as edema.
RESUMO
INTRODUCTION: Benign osteoblastoma (OB) is an unusual primary bone tumor. The preferred locations are the posterior arch of vertebrae and long bones. We report herein an extremely rare location of an OB in the mastoid process of the temporal bone. CASE REPORT: A 22-year-old woman presented with painful left retro-auricular swelling. Computed tomography features were suggestive of an aggressive osteolytic lesion of the left mastoid. The pathologic examination of bone curettage material revealed a benign OB. A complete resection of the tumor was performed later, with no evidence of recurrence at 1 year. DISCUSSION/CONCLUSION: To our knowledge, this is the 14th reported case of OB confined to the mastoid process of temporal bone. Its histological diagnosis can be difficult and osteosarcoma is its principal differential diagnosis. Although generally regarded as benign, OB has potential for recurrence and local invasion. As such, complete resection, whenever possible, is preferred over conventional curettage.
Assuntos
Neoplasias Ósseas/diagnóstico , Processo Mastoide , Osteoblastoma/diagnóstico , Feminino , Humanos , Adulto JovemRESUMO
Gougerot Sjögren syndrome is rare during childhood. Diagnosis in adult patients is usually based on sets of criteria combining clinical, serological, and salivary gland histopathological findings. In the pediatric age group, clinical manifestations might be different from the adult form. We report on 3 cases of childhood Gougerot Sjögren syndrome.
Assuntos
Glândulas Salivares/patologia , Síndrome de Sjogren/diagnóstico , Adolescente , Antimaláricos/uso terapêutico , Artralgia/etiologia , Bromoexina/uso terapêutico , Quimioterapia Combinada , Expectorantes/uso terapêutico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Soluções Oftálmicas/administração & dosagem , Síndrome de Sjogren/complicações , Síndrome de Sjogren/tratamento farmacológico , Síndrome de Sjogren/patologia , Resultado do Tratamento , Xeroftalmia/etiologia , Xerostomia/etiologiaRESUMO
Myofibroblastic proliferations of the bladder in adults are unusual lesions with a benign course. These proliferations, whether spontaneous or secondary to instrumentation, have identical morphology and behaviour. Histologically, similar lesions have been reported in the literature using different names, such as inflammatory pseudotumour, pseudosarcomatous fibromyxoid tumour, nodular fasciitis, postoperative spindle cell nodule... Recently, some authors proposed that these lesions are similar enough to be considered the same entity, designated as "pseudosarcomatous myofibroblastic proliferation" and insisted on the necessity to distinguish them from the inflammatory myofibroblastic tumour of the childhood. The latter, recently recognized as tumour, has a malignant potential and is capable of giving metastases. We describe the case of a 17-year-old man who presented a vesical mass. The histopathological study concluded to a pseudosarcomatous myofibroblastic proliferation. We discuss, through a literature review, the relationship of this lesion with inflammatory myofibroblastic tumour and its main differential diagnoses.
Assuntos
Doenças da Bexiga Urinária/patologia , Adolescente , Humanos , MasculinoAssuntos
Artralgia/etiologia , Hemangioma/diagnóstico , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/patologia , Neoplasias Musculares/diagnóstico , Músculo Esquelético , Criança , Hemangioma/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Neoplasias Musculares/cirurgia , Radiografia , Resultado do TratamentoRESUMO
Joint metastasis is very rare. It usually presents as a monoarthritis. It is generally located in the knee and secondary to lung cancer. Prognosis is poor, with a mean survival term of less than six months. We report the case of a right shoulder joint metastasis from a bronchopulmonary squamous cell carcinoma in a 55-year-old male smoker. The patient presented with an atypical chronic post-traumatic arthritis, not improved by symptomatic treatment. The diagnosis was based on synovial biopsy performed during open surgery. The primitive lung cancer was confirmed by chest CT scan and bronchial biopsy.
Assuntos
Artrite Infecciosa/diagnóstico por imagem , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/secundário , Neoplasias Pulmonares/diagnóstico , Neoplasias de Células Escamosas/secundário , Articulação do Ombro/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Achados Incidentais , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias de Células Escamosas/diagnóstico por imagem , Neoplasias de Células Escamosas/patologia , RadiografiaAssuntos
Anormalidades Múltiplas , Rim/anormalidades , Ureter/anormalidades , Obstrução Ureteral/congênito , Anormalidades Múltiplas/diagnóstico por imagem , Anormalidades Múltiplas/patologia , Anormalidades Múltiplas/cirurgia , Criança , Criptorquidismo , Humanos , Masculino , Ultrassonografia , Ureter/embriologia , Obstrução Ureteral/diagnóstico por imagem , Obstrução Ureteral/patologia , Obstrução Ureteral/cirurgiaAssuntos
Meios de Contraste/efeitos adversos , Hipersensibilidade a Drogas/etiologia , Eosinofilia/etiologia , Iotalamato de Meglumina/efeitos adversos , Infarto do Miocárdio/imunologia , Idoso , Hipersensibilidade a Drogas/imunologia , Eosinofilia/imunologia , Feminino , Humanos , Infarto do Miocárdio/complicações , SíndromeAssuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Bufexamac/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Toxidermias/etiologia , Exantema/induzido quimicamente , Administração Cutânea , Pré-Escolar , Dermatite Alérgica de Contato/diagnóstico , Dermatite Atópica/tratamento farmacológico , Feminino , Humanos , Testes do EmplastroRESUMO
Pseudotumorous oncocytosis of the parotid gland is very uncommon and frequently misdiagnosed since it generally presents as a true tumor. The clinical presentation and imaging features of a 6-cm diameter left parotid mass led to the diagnosis of a tumor in a 73-year-old man. At pathology examination of the partial parotidectomy specimen the "tumor" was found to be a metaplastic oncocytic lesion. We discuss the diagnostic criteria, differential diagnosis, and etiopathogeny of this lesion.
Assuntos
Adenoma Oxífilo/diagnóstico , Neoplasias Parotídeas/diagnóstico , Adenoma Oxífilo/patologia , Adenoma Oxífilo/cirurgia , Idoso , Transformação Celular Neoplásica/patologia , Diagnóstico Diferencial , Humanos , Masculino , Glândula Parótida/patologia , Glândula Parótida/cirurgia , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/cirurgiaRESUMO
Solid cystic papillary tumors of the pancreas are rare; they occur most commonly in young women. Despite their characteristic microscopic appearance, their immunophenotype is not specific. Their prognosis is excellent after complete surgical resection. The study aim was to report two cases in female patients who were 15 and 20 years old; the first tumor was discovered fortuitously and the second girl presented with abdominal pain and vomiting. Both tumors were encapsulated and located in the tail of the pancreas. The histological study showed the papillary architecture mixed with solid areas. Immunohistochemical staining was positive only for vimentin in one case and positive for cytokeratin, chromogranin, synaptophysin, neuron specific enolase, vimentin and protein S100 in the second case.