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1.
Int J Ment Health Nurs ; 25(5): 444-51, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27339029

RESUMO

The international literature suggests workplace violence in mental health settings is a significant issue, yet little is known about the frequency, nature, severity and health consequences of staff exposure to violence in Australian mental health services. To address this gap, we examined these aspects of workplace violence as reported by mental health services employees in Victoria, Australia. The project used a cross-sectional, exploratory descriptive design. A random sample of 1600 Health and Community Services Union members were invited to complete a survey investigating exposure to violence in the workplace, and related psychological health outcomes. Participants comprised employees from multiple disciplines including nursing, social work, occupational therapy, psychology and administration staff. A total of 411 members responded to the survey (26% response rate). Of the total sample, 83% reported exposure to at least one form of violence in the previous 12 months. The most frequently reported form of violence was verbal abuse (80%) followed by physical violence (34%) and then bullying/mobbing (30%). Almost one in three victims of violence (33%) rated themselves as being in psychological distress, 54% of whom reported being in severe psychological distress. The more forms of violence to which victims were exposed, the greater the frequency of reports of psychological distress. Workplace violence is prevalent in mental health facilities in Victoria. The nature, severity and health impact of this violence represents a serious safety concern for mental health employees. Strategies must be considered and implemented by healthcare management and policy makers to reduce and prevent violence.


Assuntos
Serviços de Saúde Mental/estatística & dados numéricos , Violência no Trabalho/estatística & dados numéricos , Adulto , Serviços Comunitários de Saúde Mental/estatística & dados numéricos , Estudos Transversais , Feminino , Pessoal de Saúde/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Enfermagem Psiquiátrica/estatística & dados numéricos , Assistentes Sociais/estatística & dados numéricos , Estresse Psicológico/psicologia , Inquéritos e Questionários , Vitória/epidemiologia , Adulto Jovem
2.
Bioorg Med Chem Lett ; 21(14): 4215-9, 2011 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-21669521

RESUMO

Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.


Assuntos
Inibidores de Metaloproteinases de Matriz , Inibidores de Proteases/química , Zinco/química , Sítios de Ligação , Domínio Catalítico , Cristalografia por Raios X , Metaloproteinase 13 da Matriz/metabolismo , Inibidores de Proteases/síntese química , Inibidores de Proteases/farmacologia , Estereoisomerismo , Relação Estrutura-Atividade
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