RESUMO
Granulosa cell tumour is among the rarest forms of testicular cancer. Only 21 cases have been reported to date and only 4 have metastasised. All documented metastases are intra-abdominal. We present the first case of granulosa cell tumour of the testis metastasising to bone (tibia), presenting 6 years after orchidectomy. This highlights the need to maintain a high index of suspicion for extra-abdominal metastases during long-term follow-up in patients with previous testicular granulosa cell tumour.
Assuntos
Neoplasias Ósseas/secundário , Tumor de Células da Granulosa/secundário , Neoplasias Testiculares/patologia , Tíbia , Biópsia , Neoplasias Ósseas/diagnóstico , Diagnóstico Diferencial , Seguimentos , Tumor de Células da Granulosa/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias Testiculares/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
1. p-Aminophenol is the major metabolite produced by urodele amphibian tissues in vitro. The deacetylation enzyme system involved is located in the liver microsomal fraction of Amphiuma means. 2. Paracetamol was deacetylated to p-aminophenol by organ cultures of liver, kidney, pancreas and stomach epithelium from adult A. means, by liver, stomach epithelium, bladder and lung cultures from neotenic larval Ambystoma tigrinum, and by adult Triturus cristatus carnifex in vivo. 3. Liver cultures from all seven urodele amphibian species metabolized paracetamol and produced p-aminophenol, but no evidence was found of paracetamol metabolism by liver cultures from any of five anuran amphibian species. 4. The significance of p-aminophenol production from paracetamol and of this difference within the Amphibia are discussed.