Adult granulosa cell tumour of the testis and bony metastasis. A report of the first case of granulosa cell tumour of the testicle metastasising to bone.

Granulosa cell tumour is among the rarest forms of testicular cancer. Only 21 cases have been reported to date and only 4 have metastasised. All documented metastases are intra-abdominal. We present the first case of granulosa cell tumour of the testis metastasising to bone (tibia), presenting 6 years after orchidectomy. This highlights the need to maintain a high index of suspicion for extra-abdominal metastases during long-term follow-up in patients with previous testicular granulosa cell tumour.

A comparative study of the deacetylation of paracetamol by urodele and anuran amphibian organ cultures.

1. p-Aminophenol is the major metabolite produced by urodele amphibian tissues in vitro. The deacetylation enzyme system involved is located in the liver microsomal fraction of Amphiuma means. 2. Paracetamol was deacetylated to p-aminophenol by organ cultures of liver, kidney, pancreas and stomach epithelium from adult A. means, by liver, stomach epithelium, bladder and lung cultures from neotenic larval Ambystoma tigrinum, and by adult Triturus cristatus carnifex in vivo. 3. Liver cultures from all seven urodele amphibian species metabolized paracetamol and produced p-aminophenol, but no evidence was found of paracetamol metabolism by liver cultures from any of five anuran amphibian species. 4. The significance of p-aminophenol production from paracetamol and of this difference within the Amphibia are discussed.