[Effect of combined hormonal oral contraception on the somatic and psychic status of women of reproductive age].

The paper is devoted to the topical problem of maintaining somatic and psychic health of the women of reproductive age by rational pregnancy planning and prevention of abortions by modern methods of contraception including combined oral hormonal contraception. Unfortunately, this approach is rarely employed in this country (5-6%). Results of retrospective analysis of medical documentation, clinical efficacy and safety of modern combined oral hormonal contraception are presented.

[Features of lipoxygenase from cells of Mortierella species mushrooms]. / Osobennosti lipoksigenzay iz kletok gribov roda Mortierella.

The specific activity of lipoxygenase from several strains of the zygomycete Mortierella varied from 1.02 to 2.02 microMol diene per min per mg protein). The enzyme equally used linoleic or arachidonic acid as a substrate. An increase in lipoxygenase activity was observed after adding corn oil to the culture medium. Tests with inhibitors having different chemical structures revealed that the lipoxygenase activity from Mortierella cells was inhibited only by esculetin, ethanol and nordihydroguaiaretic acid (NDGA). NDGA inhibited the enzyme in vitro (IC50 = 142 microM), but its addition in the exponential phase of growth activated the enzyme.

[Regulation of expression of adrenergic receptors by steroid hormones]. / Reguliatsiia ékspressii adrenergicheskikh retseptorov steroidnymi gormonami.

Steroid hormones regulate density of adrenergic receptors in peripheral tissues and in the brain. The hormones affect transcription of the adrenergic receptors genes, the receptor protein synthesis and modifications. Steroid-induced changes in adrenergic receptors densities may be an important link for the effects of steroid hormones on hormone-dependent functions and behaviour.

[THe development of systems for the early rehabilitation of patients with ischemic heart disease following aortocoronary bypass]. / Razrabotka kompleksov rannei reabilitatsii bol'nykh ishemicheskoi bolezn'iu serdtsa posle aortokoronarnogo shuntirovaniia.

Two rehabilitation complexes are described for coronary heart disease patients early after aortocoronary shunting. The first complex includes "dry" effervescent baths, magnetolaser therapy applied to the heart area, cryomassage of the abdomen. The second complex consisted of the above modalities plus dry air baths. Indications and contraindications to these complexes are specified.