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LaNb0.8 M0.2 O4-δ (where M=As, Sb, V, and Ta) oxides with pentavalent elements of different ionic sizes were synthesized by a solid-state reaction method. The vibrational properties of these oxides have been investigated. These studies revealed that the substituent element influences both Debye temperature value as well as the Raman active vibrational modes. Additionally, the low-temperature vibrational properties of LaNb0.8 Sb0.2 O4-δ have been determined to show the phase transition occurrence at 260â K which is lower than previously reported.
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Óxidos , Análise Espectral Raman , Análise Espectral Raman/métodos , Temperatura , Transição de Fase , Óxidos/química , Temperatura BaixaRESUMO
The male beard is one of the most visually salient and sexually dimorphic traits and a hypothesized potential marker of other traits, such as dominance, masculinity, social status, and self-confidence. However, as men can easily alter their facial hair, beards may provide unreliable information about the beard owner's characteristics. Here, we examined whether beards are honest signals of biological (testosterone levels) and psychological (self-reported dominance) traits. Young (M = 21.29, SD = 1.54) and healthy men (N = 97) participated in the study. Their beards were measured directly (using digital calipers) and by self-report. Participants provided saliva samples before and after acute exercise (to assess their testosterone and cortisol levels) and reported their dominance on a 5-item scale. The results showed that beard length (directly measured and self-reported) was not related to testosterone levels or dominance; thus, no evidence was found to support the hypothesis that beards are honest (or dishonest) signals of the beard owners' testosterone levels and dominance.
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Status Social , Testosterona , Face , Humanos , Masculino , Masculinidade , Saliva , Comportamento Sexual , Predomínio SocialRESUMO
Two-dimensional (2D) magnets such as chromium trihalides CrX3 (X = I, Br, Cl) represent a frontier for spintronics applications and, in particular, CrCl3 has attracted research interest due its relative stability under ambient conditions without rapid degradation, as opposed to CrI3. Herein, mechanically exfoliated CrCl3 flakes are characterized at the atomic scale and the electronic structures of pristine, oxidized, and defective monolayer CrCl3 phases are investigated employing density functional theory (DFT) calculations, scanning tunneling spectroscopy (STS), core level X-ray photoemission spectroscopy (XPS), and valence band XPS and ultraviolet photoemission spectroscopy (UPS). As revealed by atomically resolved transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) analysis, the CrCl3 flakes show spontaneous surface oxidation upon air exposure with an extrinsic long-range ordered oxidized O-CrCl3 structure and amorphous chromium oxide formation on the edges of the flakes. XPS proves that CrCl3 is thermally stable up to 200 °C having intrinsically Cl vacancy-defects whose concentration is tunable via thermal annealing up to 400 °C. DFT calculations, supported by experimental valence band analysis, indicate that pure monolayer (ML) CrCl3 is an insulator with a band gap of 2.6 eV, while the electronic structures of oxidized and Cl defective phases of ML CrCl3, extrinsically emerging in exfoliated CrCl3 flakes, show in-gap spin-polarized states and relevant modifications of the electronic band structures.
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OBJECTIVES: Facial attractiveness is thought to reflect an individual's biological condition. This seems to be largely explained by the relationship between facial appearance and body adiposity, a trait that affects various aspects of body homeostasis, including fertility and immunity. The aim of this study was to test if, a part of adipose tissue amount, also levels of hormones secreted by adipose tissue are reflected in women's appearance, focusing on the two most abundant adipokines. Due to the opposing effects of adiponectin and leptin on health, we hypothesized that leptin negatively and adiponectin positively correlate with women's attractiveness. METHODS: The study sample included 174 young, healthy women (Mage = 28.50, SDage = 2.38). Serum leptin and adiponectin levels were measured. Estradiol (E2), testosterone (T), and BMI levels were controlled in the analyses. Face photographs were taken and facial attractiveness ratings, assessed by men, were gathered in online questionnaires. RESULTS: Perceived facial attractiveness correlated negatively with leptin level and leptin/adiponectin ratio, but did not correlate with adiponectin level. The results were similar, when controlled for E2, T, and BMI. Adipokines levels did not mediate or moderate the relationship between facial attractiveness and BMI. CONCLUSIONS: The results showed that perceived facial attractiveness is predicted by adipose-derived hormones detrimental for health, like leptin, but is not related with beneficial hormones, such as adiponectin. However, the levels of these two adipokines do not impact the relationship between perceived facial attractiveness and adiposity, and thus do not explain the relationship between facial attractiveness, body adiposity, and biological condition.
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Adipocinas/sangue , Beleza , Face/fisiologia , Adiposidade , Adulto , Antropologia Física , Feminino , Saúde , Humanos , Leptina/sangue , Masculino , Homens/psicologiaRESUMO
Facial appearance has been suggested to provide an honest cue of an individual's biological condition. However, there is little direct evidence that facial attractiveness reflects actual health. Here we tested if facial appearance is related with metabolic health biomarkers. Face photographs of 161 healthy, young women (Mage = 28.59, SDage = 2.34) were assessed in terms of perceived attractiveness and health. Metabolic health was evaluated based on levels of markers of lipid and glucose metabolism balance, liver functioning, and inflammation. BMI, testosterone (T), and estradiol (E2) levels were controlled. Facial attractiveness, but not health, was negatively related with lipid profile components detrimental to health (total cholesterol, LDL, triglycerides) but not with relatively protective for health HDL. When controlled for BMI, E2, and T, only the relationship between attractiveness and triglycerides remained significant. Facial appearance was unrelated with glucose metabolism, liver functioning, and inflammatory markers. The results suggest, that for healthy women of reproductive age, such measures as BMI and sex hormone levels may be better predictors of attractiveness, compared to measures of metabolic health. Markers of lipid, glucose homeostasis, liver functioning or low-grade inflammation may be rather indicators of future health, of lesser importance in mating context, thus only modestly reflected in facial appearance.
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Biomarcadores/metabolismo , Saúde , Metabolismo , Adulto , Face , Feminino , Humanos , Análise de Componente Principal , Análise de RegressãoRESUMO
BACKGROUND: Women's morphological femininity is perceived to develop under the influence of sex hormones and to serve as a cue of estradiol level, fertility and health in mating context. However, as the studies on direct relationship between femininity and sex steroid levels have reported mixed results, it is still not well understood what factors contribute to inter-women variation in morphological femininity. Epidemiological studies show that indicators of adverse conditions during intrauterine growth and development in utero, such as low birthweight or relative thinness at birth, influence women's physiology ovarian functioning and may be associated with life-time exposure to estradiol in women. Thus, here we tested if birth parameters are also related with the level of morphological femininity in adult women. RESULTS: One hundred sixty-five healthy women of mean age 28.47 years (SD = 2.39) participated in the study. Facial femininity was estimated based on facial width-to-height ratio (fWHR) and facial shape sexual dimorphism measured in the photos. Body femininity was estimated based on waist-to-hip ratio (WHR) and breast size. Birth weight and birth length were obtained from medical records and ponderal index at birth was calculated. No relationship between birth parameters and facial or body femininity in women of reproductive age was found, also when controlled for adult sex steroid levels and BMI. CONCLUSIONS: The results suggest that, although previous research showed that birth parameters predict reproductive development and adult oestradiol level, they do not explain the variance in morphological femininity in women of reproductive age, trait that is thought to be a cue of a woman's estradiol level and fertility in mating context.
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Peso ao Nascer , Face/anatomia & histologia , Feminilidade , Caracteres Sexuais , Adulto , Mama , Feminino , Fertilidade , Humanos , Recém-Nascido , Gravidez , Relação Cintura-QuadrilRESUMO
The digit ratio (2D:4D) is said to be a potential marker of exposure to prenatal sex steroids. Some studies suggest that the 2D:4D is also linked with the testosterone response to challenging situations due to organizational effect of prenatal hormonal milieu on adult endocrine functioning. However, up to date, there were only four studies (conducted on small samples) that examined the 2D:4D and the testosterone response to a challenging situation (i.e. physical exertion or aggressive context). Here, we examined the relationship between the 2D:4D and the testosterone change under an acute exercise among 97 men. We found that the digit ratios (the right 2D:4D, the left 2D:4D, and the right minus left 2D:4D) were neither predictors of pre-exercise testosterone, nor the change in testosterone level after a cycling task. Our results add a contradictory to previous studies evidence in a discussion on the links of the 2D:4D and the testosterone change.
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Exercício Físico/fisiologia , Dedos/anatomia & histologia , Saliva/química , Testosterona/análise , Adulto , Humanos , Masculino , Adulto JovemRESUMO
Magnetic crystals formed by 2D layers interacting by weak van der Waals forces are currently a hot research topic. When these crystals are thinned to nanometric size, they can manifest strikingly different magnetic behavior compared to the bulk form. This can be the result of, for example, quantum electronic confinement effects, the presence of defects, or pinning of the crystallographic structure in metastable phases induced by the exfoliation process. In this work, an investigation of the magnetism of micromechanically cleaved CrCl3 flakes with thickness >10 nm is performed. These flakes are characterized by superconducting quantum interference device magnetometry, surface-sensitive X-ray magnetic circular dichroism, and spatially resolved magnetic force microscopy. The results highlight an enhancement of the CrCl3 antiferromagnetic interlayer interaction that appears to be independent of the flake size when the thickness is tens of nanometers. The estimated exchange field is 9 kOe, representing an increase of ≈900% compared to the one of the bulk crystals. This effect can be attributed to the pinning of the high-temperature monoclinic structure, as recently suggested by polarized Raman spectroscopy investigations in thin (8-35 nm) CrCl3 flakes.
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Conversion coatings are one of the primary types of galvanic coatings used to protect steel structures against corrosion. They are created through chemical reactions between the metal surface and the environment of the phosphating. This paper investigates the impact that the addition of new metal cations to the phosphating reaction environment has on the quality of the final coating. So far, standard phosphate coatings have contained only one primary element, such as zinc in the case of zinc coatings, or two elements, such as manganese and iron in the case of manganese coatings. The structural properties have been determined using a scanning electron microscope (SEM), X-ray diffraction (XRD), and electrochemical tests. New manganese coatings were produced through a reaction between the modified phosphating bath and the metal (Ba, Zn, Cd, Mo, Cu, Ce, Sr, and Ca). This change was noticeable in the structure of the produced manganese phosphate crystallites. A destructive effect of molybdenum and chromium was demonstrated. Microscopic analysis, XRD analysis and electrochemical tests suggest that the addition of new metal cations to the phosphating bath affects the corrosion resistance of the modified coating.
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Increased reproductive success is among the most commonly proposed adaptive functions of romantic love. Here, we tested if hormonal changes associated with falling in love may co-vary with hormonal profiles that predict increased fecundity in women. We compared blood serum levels of estradiol (E2, E2/T), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (fT), and cortisol (CT), measured in the early follicular phase of the menstrual cycle in single women (N = 69) and in women at the beginning of a romantic heterosexual relationship who reported being in love with their partner (N = 47). Participants were healthy, regularly cycling women aged 24 to 33 who did not use hormonal contraception. We found that women in love had higher levels of gonadotropins (FSH, LH) and lower testosterone levels compared to single women who were not in love. These groups of women did not, however, differ in terms of estradiol, prolactin, or cortisol levels.
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Hormônios Esteroides Gonadais/sangue , Amor , Adulto , Feminino , Humanos , Reprodução , Parceiros Sexuais , Adulto JovemRESUMO
Fluctuating asymmetry (FA), a morphological marker of developmental stability, may be related to an individual's biological condition, e.g., health or fertility. The aim of this study was to test if the level of a woman's FA was related to her fertility and reproductive potential as measured by reproductive hormone levels. Fifty-three healthy, non-pregnant, naturally cycling women (mean age = 23.42, SD = 1.85 years), participated in the study, conducted in Wroclaw (Poland) in May 2015. Early-follicular phase serum levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were measured. FA was calculated based on anthropometric measures of six bilateral body traits, and the composite FA index was used in statistical analyses. No relationship was observed between FA and the levels of FSH, LH, and AMH (p > .05), controlled for potential confounders. However, the level of E2 was positively correlated with FA (p < .05). Thus, in young women, FA was not related to hormones levels related to ovarian reserve, but more symmetrical women had lower E2 levels. As FA is an index of developmental stability, environmental, and genetic stress, the results of the study confirm previous research suggesting that developmental conditions may be related to women's endogenous estrogen levels.
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Hormônio Antimülleriano/sangue , Estradiol/sangue , Fertilidade , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Adulto , Antropometria , Constituição Corporal , Feminino , Voluntários Saudáveis , Humanos , Adulto JovemRESUMO
Manganese phosphate coating could be used to protect the surface of steel products. However, it is essential to determine the effects which process parameters, as well as the types of additives used, have on the efficiency of coating deposition. Thus, we present here a process of phosphatization of low-alloy steel (for 15 min at 95 °C) in manganese/nickel baths followed by a passivation process with the use of a silicon and zircon compounds. The microstructure and morphology of the surface were analyzed by SEM EDX and XRD methods. The obtained results showed that the manganese phosphate could be effectively formed at 95 °C in the solution containing nickel and guanidine derivatives. Anodic polarization of manganese coating was investigated in 0.5 M KCl by the analysis of polarization resistance. The effects of the activation process on corrosion properties of the coating have been examined. It was observed that an increased concentration of activating substances in the activation bath results in the enhancement of corrosion resistance.
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OBJECTIVES: More symmetric organisms are perceived as more attractive. Fluctuating asymmetry (FA) i.e. small, random deviations from perfect bilateral symmetry, is supposed to inform about developmental instability. According to the good genes hypothesis, a low level of FA is a putative cue to an organism's biological quality. An important aspect of this quality is the immune system functioning. The aim of this study was to evaluate the relationship between immune system functioning and body symmetry in healthy people. MATERIALS AND METHODS: The composite body FA (cFA) was assessed on the basis of six bilateral traits (on hands and feet). The ISF was determined by many innate (total complement and lysozyme activity, neutrophils function) and adaptive immune parameters (T CD3 and B CD19 lymphocytes, total IgA and IgG and response to flu vaccine). A total of 98 men and 92 women were subjected to flu (among them 37 men and 30 women also to tetanus) vaccination. The blood samples were collected before and 4 weeks after the antigens exposure. Immunomodulatory factors: participant's age, body fat, and free testosterone level, were controlled. RESULTS: Apart from the weak positive association between CD3 or CD19 and cFA in men, we found no association between the level of body symmetry and the rest of the analyzed immune parameters for both sexes. DISCUSSION: Our results are the opposite of the good genes hypothesis prediction and suggest that in western, healthy populations, human mate preferences for more symmetric bodies are not related to immune competence.
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Constituição Corporal , Sistema Imunitário , Imunocompetência , Adulto , Antropologia Física , Antropometria , Anticorpos Antivirais/sangue , Constituição Corporal/imunologia , Constituição Corporal/fisiologia , Proteínas do Sistema Complemento/análise , Feminino , Dedos/anatomia & histologia , Pé/anatomia & histologia , Humanos , Sistema Imunitário/imunologia , Sistema Imunitário/fisiologia , Imunocompetência/imunologia , Imunocompetência/fisiologia , Vacinas contra Influenza/imunologia , Masculino , Fenótipo , Análise de Regressão , Adulto JovemRESUMO
Examining the effects of acute stress across multiple modalities (behavioral, physiological, and endocrinological) can increase our understanding of the interplay among stress systems, and may improve the efficacy of stress detection. A multimodal approach also allows for verification of the biological stress response, which can vary between individuals due to myriad internal and external factors, thus allowing for reliable interpretation of behavioral markers of stress. Here, controlling for variables known to affect the magnitude of the stress response, we utilized the Trier Social Stress Test (TSST) to elicit an acute stress response in 80 healthy adult men and women. The TSST involves an interview-style oral presentation and critical social evaluation, and is highly effective in inducing psychosocial stress. Participants completed the study in individual 2â¯h sessions, during which we collected voice, polygraph and salivary hormone measures in baseline, stress, and relaxation phases. Our results show sizeable systematic increases in voice pitch (mean, minimum and variation in fundamental frequency, F0), hormone levels (cortisol) and decreases in skin temperature and hand movement during psychosocial stress, with striking similarities between men and women. However, cortisol and skin temperature only weakly predicted changes in voice pitch during stress, in either women or men, respectively. Thus, while our results provide compelling evidence that psychosocial stress manifests itself behaviorally by increasing voice pitch and its variability alongside simultaneous activation of physiological and endocrinological stress systems, our results also highlight a relatively weak degree of intra-individual 'response coherence' across these stress systems, with dissociations among different stress measures related most strongly to sex.
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Técnicas de Diagnóstico Neurológico , Hidrocortisona/análise , Comportamento Social , Estresse Fisiológico/fisiologia , Estresse Psicológico/diagnóstico , Voz/fisiologia , Adulto , Teste de Esforço , Feminino , Mãos , Humanos , Hidrocortisona/metabolismo , Masculino , Movimento/fisiologia , Saliva/química , Saliva/metabolismo , Temperatura Cutânea/fisiologia , Fala/fisiologia , Medida da Produção da Fala/métodos , Estresse Psicológico/metabolismo , Estresse Psicológico/fisiopatologia , Estresse Psicológico/psicologiaRESUMO
The observations that testosterone might be immunosuppressive, form the basis for the immunocompetence handicap hypothesis (ICHH). According to ICHH only high-quality individuals can maintain high levels of testosterone and afford the physiological cost of hormone-derived immunosuppression. The animal and human studies that attempted to support the ICHH by precisely defined impairment of immunity associated with high testosterone levels are inconclusive. Furthermore, human studies have used only selected immune functions and varying testosterone fractions. This is the first study examining the relationship between multiple innate and adaptive immunity and serum levels of free testosterone, total testosterone, DHT and DHEA in ninety-seven healthy men. Free testosterone and marginally DHT levels were positively correlated with the strength of the influenza post-vaccination response. Total testosterone and DHEA showed no immunomodulatory properties. Our findings did not support ICHH assumptions about immunosuppressive function of androgens. In the affluent society studied here, men with higher levels of free testosterone could afford to invest more in adaptive immunity. Since the hormone-immune relationship is complex and may depend on multiple factors, including access to food resources, androgens should be treated as immunomodulators rather than implicit immunosuppressants.
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Imunocompetência , Testosterona/sangue , Adulto , Humanos , Imunidade , Masculino , Adulto JovemRESUMO
According to the good genes hypothesis and energy allocation theory, human adult body height may reflect biological quality. An important aspect of this quality is immune system functioning (ISF). The aim of this study was to evaluate the relationship between ISF and body height in healthy people. The ISF was determined by several important innate (total complement and lysozyme activity, neutrophil function) and adaptive immune parameters (lymphocytes, IgA and IgG, and response to the flu vaccine). Overall, 96 males and 97 females were subjected to flu vaccination, and of these, 35 males and 34 females were subjected to tetanus. Blood samples were collected before and four weeks after vaccination. Immunomodulatory factors, participant's age, body fat, and free testosterone levels, were controlled. There was no association between body height and all analysed immune parameters for both sexes. That might suggest that in Western society, a women's preference for taller men is not related to 'good genes for immune competence'. We propose the novel Immunity Priority Hypothesis that explains the lack of relationship between adult body stature and ISF. This hypothesis, however, does not contradict the signalling role of a man's body height as a morphological marker of biological quality.
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Estatura , Sistema Imunitário , Feminino , Humanos , Vacinas contra Influenza/administração & dosagem , Masculino , Toxoide Tetânico/administração & dosagemRESUMO
BACKGROUND: Male gender and adiposity are considered to be risk factors for Staphylococcus aureus carriage. We tested whether colonization is related to free testosterone (fT) level and adiposity, measured with body mass index (BMI) and body fat percentage (BFP), in healthy adults. METHODS: Blood sample and throat swabs were taken twice (at 4-week intervals) from healthy men and women aged 18-36 years. fT level, height, weight, and BFP were measured. Participants were classified as persistent carriers, intermittent carriers (excluded from the analyses), and noncarriers. The final sample was 152 participants: 85 men and 67 women. RESULTS: BFP, but not BMI, correlated positively with S aureus colonization (P = .02) in men. BMI became a significant predictor of carriage only when comparing groups within and above norms (P = .04). There was no relationship for BMI nor BFP in women. Higher fT level was related to persistent carriage (P = .02) in women, there was no relationship for fT level in men. CONCLUSION: Risk factors for S aureus carriage are sex dependent. Within-sex variation in colonization is related to fT level in women, whereas in men it is related to the amount of body fat.
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Portador Sadio/epidemiologia , Faringe/microbiologia , Infecções Estafilocócicas/epidemiologia , Staphylococcus aureus/isolamento & purificação , Adolescente , Adulto , Feminino , Voluntários Saudáveis , Humanos , Masculino , Obesidade/complicações , Fatores de Risco , Fatores Sexuais , Testosterona/sangue , Adulto JovemRESUMO
Despite a long history of empirical research, the potential vocal markers of stress remain unclear. Previous studies examining speech under stress most consistently report an increase in voice pitch (the acoustic correlate of fundamental frequency, F0), however numerous studies have failed to replicate this finding. In the present study we tested the prediction that these inconsistencies are tied to variation in the severity of the stress response, wherein voice changes may be observed predominantly among individuals who show a cortisol stress response (i.e., an increase in free cortisol levels) above a critical threshold. Voice recordings and saliva samples were collected from university psychology students at baseline and again immediately prior to an oral examination. Voice recordings included both read and spontaneous speech, from which we measured mean, minimum, maximum, and the standard deviation in F0. We observed an increase in mean and minimum F0 under stress in both read and spontaneous speech, whereas maximum F0 and its standard deviation showed no systematic changes under stress. Our results confirmed that free cortisol levels increased by an average of 74% (ranging from 0 to 270%) under stress. Critically, increases in cortisol concentrations significantly predicted increases in mean F0 under stress for both speech types, but did not predict variation in F0 at baseline. On average, stress-induced increases in voice pitch occurred only when free cortisol levels more than doubled their baseline concentrations. Our results suggest that researchers examining speech under stress should control for individual differences in the magnitude of the stress response.
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Hidrocortisona/metabolismo , Individualidade , Percepção da Altura Sonora/fisiologia , Fala/fisiologia , Voz/fisiologia , Adulto , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Saliva/metabolismo , Estresse Psicológico/sangue , Adulto JovemRESUMO
According to the compensatory prophylaxis hypothesis, women in the luteal phase, characterized by a high progesterone level, which suppresses various mechanisms of immune response, should exhibit higher disgust sensitivity, compared to the follicular phase. In this study we test the hypothesis on the compensatory role of disgust sensitivity at the luteal phase of the menstrual cycle, when immune functions are expected to change due to a rise in progesterone level. Disgust sensitivity, progesterone level (P) and white blood cell count (WBC), a general marker of immunocompetence, were measured in 30 healthy women of reproductive age. Disgust sensitivity was evaluated with: 1) Disgust Scale Revised (DS-R) containing three subscales: Core Disgust, Animal Reminder and Contamination Disgust, 2) Pathogen Disgust and Moral Disgust domains of the Three-Domain Disgust Scale. Measurements were conducted twice - in menstruation (the lowest P) and in the mid-luteal phase (the highest P). The results were analyzed longitudinally and using cross-sectional comparisons. Progesterone level, WBC count, and the level of disgust sensitivity in Animal Domain were higher in the mid-luteal phase comparing to menstruation. The level of disgust sensitivity (DS-R score, Animal, Contamination, Pathogen Disgust) correlated only with P (not WBC) and only in the mid-luteal phase (not in menstruation) in between-subjects comparisons. On the base of these results, we hypothesize that the level of disgust sensitivity in the whole menstrual cycle of a woman is "adjusted" to the luteal phase with the highest P level i.e. when immunosuppression is the greatest.
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Hostilidade , Leucócitos/fisiologia , Ciclo Menstrual/fisiologia , Progesterona/sangue , Adulto , Feminino , Humanos , Contagem de Leucócitos/métodos , Adulto JovemRESUMO
OBJECTIVES: Total leukocyte count (white blood cells-WBC) and the count of each subpopulation vary across the menstrual cycle, but results of studies examining the time and direction of these changes are inconsistent and methodologically flawed. Besides, no previous study focused on leukocyte count on the day of ovulation. METHODS: Blood samples were obtained from 37 healthy and regularly cycling women aged 19.8-36.1 years. Samples were taken three times: during menstruation (M), ovulation (O), and in the mid-luteal phase (ML). WBC, neutrophils, lymphocytes, mixed cells, progesterone (P,) and estradiol (E) were measured in each of the three target phases of the cycle. RESULTS: Compared to menstruation, WBC (P = 0.002) and neutrophils (P < 0.001) increased around ovulation and remained stable in the mid-luteal phase, whereas lymphocyte and mixed cell counts did not change throughout the menstrual cycle. There were some correlations of sex hormone variation with leukocyte changes between M and O (positive for E and WBC, negative for P and WBC and for P and neutrophil count; P < 0.05), but not between O and ML. CONCLUSIONS: Peripheral leukocyte changes taking place in the second half of the cycle are already observable on the day of ovulation and they are associated with sex hormone variation. We speculate that these changes may lead to increased immune protection against pathogens at a time when fertilization and implantation typically occur. Am. J. Hum. Biol. 28:721-728, 2016. © 2016 Wiley Periodicals, Inc.