Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Not Clinically Useful in Predicting Prognosis in Early Stage Cervical Cancer.

BACKGROUND: An objective of this study was to determine the prognostic role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (CC) stages IA2-IB1. METHODS: The study included 484 patients who underwent radical hysterectomy with pelvic node dissection. The associations of preoperative NLR and PLR with clinicopathologic characteristics and oncological outcomes were analyzed. The cut-off values of NLR (=1.8) and PLR (=119) were set as medians. RESULTS: The clinicopathologic analysis showed that NLR was associated with age (p=0.010), tumor size (p=0.045), and adjuvant treatment (p=0.005), and PLR was associated with only adjuvant treatment (p=0.033). DFS and OS were not significantly different between patients with high and low NLR (p=0.670 and p=0.934) or high and low PLR (p=0.780 and p=0.306). The independent prognostic factors associated with OS were lymph node status and anemia, and with DFS were histology, deep stromal invasion, and lymph node status. CONCLUSIONS: NLR and PLR have no use as prognostic biomarker for DFS and OS in early-stage CC. However, NLR and PLR might be of use in determining the risk for adjuvant treatment.

Pregnancy outcome and predictive factors for adverse pregnancy outcomes of cephalopelvic disproportion pregnancies in a resource-limited setting with an efficient referral system.

OBJECTIVE: Small local hospitals with inexperiencedpersonnel often have adverse incidence that could be prevented. A good referral system could reduce this unnecessary death rate. The present study was conducted to determine the pregnancy outcomes of cephalopelvic disproportion (CPD) cases that were referred for cesarean section at a tertiary center and presented the predictivefactorsfor adverse pregnancy outcomes. MATERIAL AND METHOD: A retrospective study that descriptively presented the adverse pregnancy outcome in referred CPD pregnancies and analyzed for predictive factor of overall adverse pregnancy outcome. RESULTS: One hundred ninety five referred CPD pregnancies were included in this study. The mean duration ± SD from CPD diagnosis to childbirth was 232.32±103.75 minutes. Pregnancy additional complication was found in 42/195 (21.5%) cases, but there were no maternal or neonatal mortalities. The NICU admission and postpartum hemorrhage rates were 21.5% and 12.3%, respectively. Obesity BMI was associated with an increased risk of overall adverse maternal outcomes (OR 3.12). Previously complicated pregnancy and cervical dilatation at CPD diagnosis were significant predictors for overall neonatal adverse outcomes. The highest risk wasforpregnant women who were cesarean delivered at 10 cm cervical dilatation (OR 2.84 vs. cervical dilatation ≤5 cm, p-value 0.002). CONCLUSION: A referral system is one of the modalities to avoid maternal and neonatal mortality for CPD pregnant women in a resource-limited setting. We suggest that early referral before advanced progression of cervical dilatation, especially in obese pregnant women and in complicated pregnancies, may improve the pregnancy outcomes.