Prevalence of e-cigarette use from a nationally representative sample in New Zealand.

OBJECTIVE: To explore the prevalence of e-cigarette use in New Zealand in a nationally representative sample aged 15 years and over. METHODS: The Health and Lifestyles Survey (HLS) is a biennial face-to-face in-house survey of New Zealand adults aged 15 years or over. The HLS was completed by 3854 participants in 2016. RESULTS: 17% of adults have tried e-cigarettes, while only 2% reported current use. The prevalence of ever use of e-cigarettes was greater in young and middle-aged adults, compared with older adults, Maori compared with NZ European, and current and former smokers, compared to never smokers. Current smokers and recent quitters displayed the highest levels of e-cigarette use, with never smokers reporting low ever use (2.8%) and no regular use. Following adjusted analyses only current smokers and recent quitters were more likely to report current or daily e-cigarette use. CONCLUSION: Although 17% of adults report having tried e-cigarettes, very few report current use. It is possible that difficulty of use, compounded by lack of support, is preventing conversion to regular use or successful use as a quitting aid. Public health initiatives should inform individuals how to correctly use e-cigarettes optimally for smoking cessation, ideally targeting this messaging toward younger and middle-aged adults, Maori, current smokers, and recent quitters.

Dual use of electronic cigarettes and tobacco in New Zealand from a nationally representative sample.

OBJECTIVE: There is strong interest in the use of electronic cigarettes (e-cigarettes) globally. Not much is known about the dual use of e-cigarettes and combustible tobacco cigarettes, or if there are demographic differences among dual users and e-cigarette only users. This paper reports on the demographics of dual users and e-cigarette only users in New Zealand in a nationally representative sample. METHODS: The Health and Lifestyles Survey (HLS) is a biennial face-to-face in-house survey of New Zealand adults aged 15 years or over. The HLS was completed by 3,854 participants in 2016. RESULTS: There is clear evidence of significant dual use in the current sample: most current e-cigarette users (63.9%) were dual users. Respondents 45 years and older were twice as likely to be dual users as those aged 15 to 34 years. CONCLUSION: The current study found evidence for substantial dual use of e-cigarettes and combustible tobacco cigarettes among adult e-cigarette users, particularly among users aged 45 years and over. Implications for public health: Public health initiatives should provide clear advice that e-cigarettes should be used as a smoking cessation tool and not as a way to allow the consumption of combustible tobacco to continue.

A genetic deletion of the serotonin transporter differentially influences the behavioural effects of MDMA.

BACKGROUND: While (±)-3,4-methylenedioxymethamphetamine (MDMA) primarily induces serotonin release, it also affects dopamine and noradrenaline transmission. It is, however, unclear what role each of these neurotransmitters play in the behavioural profile of MDMA. METHODS: In this study we used the drug discrimination (DD) and the acoustic startle (ASR) paradigms to examine the behaviour of rats with and without a genetic deletion of the serotonin transporter SERT (SERT-/- and SERT+/+ rats). In DD, rats were trained to respond on different levers following an injection of 1.5 mg/kg MDMA, or saline. After acquisition, they were given a challenge dose of 0.5 mg/kg amphetamine (AMPH). In the ASR paradigm, SERT+/+ and SERT-/- rats were given 0, 5 or 10 mg/kg MDMA. RESULTS: In DD, significantly fewer SERT-/- rats acquired MDMA discrimination. When the acquirers were challenged with AMPH, SERT+/+ showed partial, while SERT-/- rats showed full generalisation to MDMA. In the ASR paradigm, MDMA significantly reduced prepulse inhibition and startle habituation in SERT+/+ rats, while having no effect in SERT-/- rats. CONCLUSION: Together these data suggest that in wildtype rats the interoceptive cues of MDMA are primarily mediated by serotonin and to a lesser extent by dopamine and noradrenaline, while the effects in the startle paradigm are almost exclusively mediated via serotonin. Together, these data contribute to our understanding of the complex pharmacodynamics of MDMA.