RESUMO
OBJECTIVES: To evaluate the significance of exclusively unifocal, unilateral, interictal epileptiform patterns on scalp electroencephalography (EEG) in surgical candidates with medically intractable extratemporal epilepsy. METHODS: We reviewed 126 patients with refractory extratemporal partial seizures who underwent epilepsy surgery at our center. All were followed for at least 2 years after resections. Surgery was based on ictal EEG recordings. We examined ictal onsets and surgical outcome in subjects whose preoperative, interictal scalp EEGs during long-term monitoring (LTM) demonstrated only unilateral, well-defined focal discharges, and outcome in patients whose interictal EEGs during LTM showed bilateral, non-localized, or multifocal epileptiform patterns. RESULTS: We found that 26 subjects exhibited only unilateral, unifocal, interictal epileptiform patterns. In all 26 cases (100%) clinical seizures arose from the regions expected by the interictal findings (P<0.0001, Sign test). At last follow-up 77% (20/26) of these patients were seizure-free, while 23% (6/26) had >75% reduction in seizures. This compares to the remaining patients, of whom 34% (34/100) were seizure-free, 41% (41/100) had >75% reduction in seizures, and 25% (25/100) had <75% reduction in seizures (P=0.0001, Fisher's Exact test). CONCLUSIONS: Strictly unifocal, interictal epileptiform patterns on scalp EEG, though seen in a minority of subjects, may be an important, independent factor in evaluating subjects with intractable extratemporal, localization-related epilepsy for surgical therapy. This finding is highly predictive of both ictal onsets and successful postsurgical outcome.
Assuntos
Encéfalo/fisiopatologia , Epilepsia do Lobo Temporal/fisiopatologia , Adolescente , Adulto , Idoso , Criança , Eletroencefalografia , Epilepsia do Lobo Temporal/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , PrognósticoRESUMO
Our purpose is to determine predictors of outcome in patients with refractory temporal lobe epilepsy and normal high resolution magnetic resonance imaging (MRI) who undergo surgical therapy. We identified 23 patients who underwent temporal lobectomy and had normal pre-operative MRI, including surface coil phased array temporal lobe imaging. All were followed at least 2 years after surgery. We graded outcome as seizure-free, > 75% reduction in seizures, or < 75% reduction in seizures. We examined pre-operative interictal and ictal electroencephalographic (EEG) findings, age of onset, gender, duration of epilepsy, risk factors, family history, physical findings, age at operation, side of operation, and pathology of resected tissue in order to determine if any of these factors were associated with outcome. Overall, 48% (11/23) of patients were seizure-free, 39% (9/23) had > 75% reduction in seizures, while 13% (3/23) had < 75% reduction in seizures. Only the EEG findings were useful in predicting outcome. When ictal onsets arose from basal-temporal regions, 61% (11/18) of patients were seizure-free, while none (0/5) were seizure-free when seizures arose from mid-posterior temporal regions (P = 0.04). Interictally, if all epileptiform patterns were localized exclusively to one basal-temporal region, a finding that invariably correlated with ictal onsets, 78% (7/9) of patients were seizure-free, while only 29% (4/14) were seizure-free if discharges were bilateral or multifocal (P = 0.04). We conclude that surgery may be a reasonable treatment for some patients with intractable temporal lobe seizures and normal MRI. The best outcomes occur when seizure onsets and interictal epileptiform patterns are exclusive to one basal-temporal region. Unfavorable outcomes are most likely to occur when ictal origins are from mid-posterior temporal regions and when interictal discharges are bitemporal or multifocal in distribution.
Assuntos
Eletroencefalografia , Epilepsia do Lobo Temporal/cirurgia , Adolescente , Adulto , Criança , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
The urinary ratio of 6-beta-hydroxycortisol/cortisol has been used as a noninvasive probe for human cytochrome P450 3A4 isoforms (CYP3A4). Ethnic-related differences in the ratio have not been evaluated. The aim of this study was to determine if there are differences in the ratio between Asian and Caucasian women over a menstrual cycle. First-morning urine samples were collected every other day starting from the second day of menstruation for a complete menstrual cycle from 15 Asians and 16 Caucasian women who were 18 to 40 years old, healthy, nonsmoking, and alcohol and drug free, including oral contraceptives. Urine concentrations of 6-beta-hydroxycortisol and cortisol were measured by high-pressure liquid chromatography (HPLC). For statistical analysis, three phases of the menstrual cycle were evaluated: menstruation (days 1-4), follicular or postmenstruation (days 6-10), and the luteal phase (days 21-24) based on the average menstrual cycle (28 days). Statistical analysis was performed by an independent sample t-test using the Bonferroni correction for repeated measures. Large intersubject and intrasubject variations of the 6-beta-hydroxycortisol/cortisol ratios were observed during the menstrual cycles in both ethnic groups. Asian women had a statistically significant lower ratio than Caucasian women did for all three phases of the menstrual cycle: 2.2 +/- 1.1 versus 5.1 +/- 3.5, 2.1 +/- 1.1 versus 6.0 +/- 4.9, and 2.8 +/- 1.6 versus 5.6 +/- 3.0 for the menstruation, follicular, and luteal phases, respectively. The two- to threefold lower 6-beta-hydroxycortisol/cortisol ratios in Asian women suggest that Asian women may have a lower CYP3A activity compared with Caucasian women. Differences in ethnicity may mask potential gender-related effects if ethnic background is not evaluated as a contributing factor.
Assuntos
Povo Asiático , Hidrocortisona/análogos & derivados , População Branca , Adolescente , Adulto , Análise de Variância , Ásia/etnologia , Citocromo P-450 CYP3A , Sistema Enzimático do Citocromo P-450/metabolismo , Feminino , Humanos , Hidrocortisona/urina , Ciclo Menstrual/urina , Oxigenases de Função Mista/metabolismoRESUMO
The purpose of this study was to determine predictors of probable outcome following reoperation for medically intractable partial epilepsy. We reviewed outcome at least 1 year after reoperation in 21 patients with intractable seizures, for whom an earlier operation had failed. We examined age of onset of epilepsy, duration of seizures, gender, details of the history and clinical examination, pre-operative magnetic resonance (MRI) findings, electroencephalographic (EEG) studies obtained before and after the failed surgery, presence or absence of lateralizing neuro-psychological deficits, sites of operation and pathology of resected tissue to identify the factors associated with outcome. We found two factors that were significantly related to outcome: (1) no individual with a history of central nervous system (CNS) infection which predated the onset of epilepsy had a seizure-free outcome after reoperation (P = 0.04). (2) Reoperations that extended previous resections, based on new ictal EEG recordings that were concordant with both EEG ictal onsets and MRI findings obtained before the first, failed surgery resulted in a seizure-free outcome or >95% reduction in seizures for 100% (7/7) of such patients. This compares to 29% (4/14) of the remaining individuals without such concordance who had a similar outcome (P = 0.009). Site of operation (temporal or extratemporal) did not, in and of itself, predict outcome. A portion of patients who fail surgery for intractable partial seizures will achieve significant improvement following reoperation. Furthermore, we may be able to identify those individuals most likely to have an excellent result from a second operation.
Assuntos
Encéfalo/cirurgia , Epilepsia/diagnóstico , Epilepsia/cirurgia , Adolescente , Adulto , Encéfalo/anatomia & histologia , Criança , Eletroencefalografia , Feminino , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Masculino , Valor Preditivo dos Testes , ReoperaçãoRESUMO
Advances in neuroimaging techniques, particularly high-resolution magnetic resonance imaging (MRI), have proved invaluable in identifying structural brain lesions in patients with epilepsy. The assumption that such focal lesions invariably predict the site of seizure origin may not be correct, however. We report a series of 20 adults with medically intractable partial epilepsy, where high-resolution brain MRI disclosed a unilateral, focal, hippocampal, or neocortical lesion as the only abnormality in each case; nevertheless, based on electroencephalographic (EEG) recordings, ictal onsets arose from a completely different location than that of the MRI lesion. All patients underwent epilepsy surgery, with the operations based on ictal EEG findings, and all were followed at least 2 years after the resection. After the most recent follow-up examination, 50% (10/20) of the patients were completely seizure-free, 35% (7/20) had at least a 75% reduction in the number of seizures, and 15% (3/20) had less than a 75% reduction in the number of seizures. We conclude that the identification of a focal, structural, hippocampal, or neocortical lesion on brain MRI is not always indicative of the site of seizure origin in partial epilepsy. Furthermore, in cases of discordance between MRI and EEG data, a good outcome after epilepsy surgery is possible if EEG ictal onsets are definitive.
Assuntos
Epilepsias Parciais/fisiopatologia , Hipocampo/patologia , Neocórtex/patologia , Adolescente , Adulto , Eletroencefalografia , Epilepsias Parciais/patologia , Feminino , Hipocampo/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neocórtex/fisiopatologiaRESUMO
PURPOSE: This study was undertaken to determine what changes, if any, occur in the electroencephalogram (EEG) and in neuropsychological test findings of adults with medically intractable complex partial epilepsy over a 10-year period. METHODS: We studied 35 adults, with a mean age of 32 years (range, 16-59 years) at time of initial testing. We compared the distribution of epileptiform patterns documented on the initial pair of waking and sleeping EEGs to those observed on another pair obtained 10 years later. During this same 10-year period, we also examined changes in the Wechsler Adult Intelligence Scale (WAIS) and on the tests from the Neuropsychological Battery for Epilepsy. RESULTS: The EEGs of 28 (80%) of patients at the tenth year were identical to those seen initially. Five (14%) of patients demonstrated EEGs after 10 years with either no discharges or only unilateral discharges, where bilateral discharges were seen a decade earlier. Only two (6%) of patients had EEGs at the tenth year that showed bilateral discharges where only unilateral discharges were seen originally. We found no general change in intelligence or neuropsychological functioning after 10 years, although a few subtle losses were noted on several neuropsychological measures. CONCLUSIONS: For most adults with medically intractable complex partial epilepsy, the EEG and neuropsychological test scores remain reasonably stable over a decade.
Assuntos
Eletroencefalografia , Epilepsias Parciais/diagnóstico , Testes Neuropsicológicos/estatística & dados numéricos , Adolescente , Adulto , Progressão da Doença , Feminino , Seguimentos , Humanos , Testes de Inteligência , Masculino , Pessoa de Meia-IdadeRESUMO
To assess the clinical utility of high-resolution inter-ictal single photon emission tomography (SPET) of regional cerebral perfusion and high-resolution magnetic resonance imaging (MRI) of the brain with a phased-array temporal lobe coil, 35 patients with presumed partial epilepsy were evaluated prospectively by these techniques in addition to prolonged video/electroencephalographic (EEG) monitoring. Twenty of these patients had surgical treatment of partial epilepsy with outcome determinations spanning from 12 months to 3 years at follow-up. There were four categories of imaging findings as compared to scalp/sphenoidal EEG localization. Category I included 12 patients (34% of total) in whom there was complete imaging and EEG concordance. Category II included 4 patients (11%) in whom MRI and EEG were concordant but SPET was divergent or normal. Category III included 13 patients (37%) in whom SPET and EEG were concordant but MRI was divergent or normal. Category IV included 4 patients (11%) in whom neither SPET nor MRI was concordant with EEG. In this study, the relative sensitivities of SPET and MRI for localization of partial epilepsy based on prolonged scalp/sphenoidal video/EEG recordings were 76% and 49%, respectively. We conclude that these neuroimaging techniques (phased-array MRI and inter-ictal cerebral perfusion SPET) are complementary and useful in the pre-operative evaluation of patients with partial epilepsy.
Assuntos
Eletroencefalografia , Epilepsias Parciais/diagnóstico , Imageamento por Ressonância Magnética , Tomografia Computadorizada de Emissão , Gravação de Videoteipe , Adolescente , Adulto , Idoso , Cisteína/análogos & derivados , Epilepsias Parciais/diagnóstico por imagem , Epilepsias Parciais/terapia , Epilepsia Parcial Complexa/diagnóstico por imagem , Epilepsia do Lobo Temporal/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Compostos de Organotecnécio , Compostos Radiofarmacêuticos , Tecnécio Tc 99m Exametazima , Lobo Temporal/diagnóstico por imagem , Fatores de Tempo , Resultado do TratamentoRESUMO
We reviewed outcome at least 1 year after temporal lobectomy in 44 patients with bitemporal, independent, interictal epileptiform patterns on EEG. All 44 underwent preoperative intracranial monitoring. Twenty-two (50%) were seizure-free, 14 (32%) had at a least 75% reduction in seizures, and eight (18%) had less than a 75% reduction in seizures. We analyzed age of seizure onset, duration of epilepsy, gender, side of operation, history and clinical findings, findings on MRI, results of intracranial EEG-video monitoring, presence or absence of lateralizing neuropsychological deficits, and pathology of resected tissue to identify factors associated with outcome. Three factors emerged as independently associated with a good outcome: concordance of MRI abnormality and side of operation (p = 0.01), history of febrile seizures (p = 0.04), and 100% lateralization of intracranially recorded ictal onsets to the side of operation (p = 0.05). A seizure-free outcome was much more likely to occur if more than one of these factors was present: with at least two factors co-existing, 83% (15/18) of patients were seizure-free, while only 35% (7/20) were seizure-free with a single factor present (p = 0.0009). Of the six patients without any of the three factors, none were seizure-free. We conclude that it is possible to predict reasonably which patients with bitemporal epileptiform abnormalities will have a good outcome after surgery.
Assuntos
Eletroencefalografia , Epilepsia/fisiopatologia , Epilepsia/cirurgia , Adolescente , Adulto , Epilepsia/diagnóstico , Feminino , Lateralidade Funcional , Humanos , Imageamento por Ressonância Magnética , Masculino , Prontuários Médicos , Pessoa de Meia-Idade , Convulsões Febris/complicações , Lobo Temporal/cirurgia , Resultado do TratamentoRESUMO
PURPOSE: We wished to compare outcome 5 years after temporal lobectomy in 28 patients selected for surgery on the basis of interictal EEG patterns with that in 46 patients who underwent EEG-video monitoring studies as part of their preoperative evaluation during the same era. METHODS: The 28 nonmonitored patients had interictal EEG patterns that demonstrated a consistent, unilateral, anterior-midtemporal epileptiform focus, without discordant findings from other studies. Outcomes were assessed for years 4 and 5 after operation. RESULTS: Twenty-six of 28 (92.9%) nonmonitored patients were seizure-free or had at least 75% reduction in seizures. Twenty-nine of 46 (63.0%) monitored patients were seizure-free or had at least 75% reduction in seizures. Preoperative interictal EEGs of 29 of these patients showed independently localized bitemporal, extratemporal, midposterior temporal, or diffuse epileptiform patterns. The remaining 17 monitored patients had preoperative strictly unilateral anterior-midtemporal interictal discharges, and their outcome was comparable to the nonmonitored group, with 15 (88.8%) seizure-free or with at least 75% reduction in seizures. CONCLUSIONS: A proportion of candidates for epilepsy surgery can be selected without ictal recordings provided that interictal EEGs demonstrate consistent unilateral anterior-midtemporal epileptiform discharges and that other data are not discordant.
Assuntos
Eletroencefalografia/métodos , Epilepsia Parcial Complexa/cirurgia , Monitorização Fisiológica , Lobo Temporal/cirurgia , Adolescente , Adulto , Astrocitoma/patologia , Mapeamento Encefálico , Neoplasias Encefálicas/patologia , Coristoma/patologia , Eletrodos Implantados , Epilepsia Parcial Complexa/diagnóstico , Epilepsia Parcial Complexa/patologia , Feminino , Seguimentos , Lateralidade Funcional/fisiologia , Gliose/patologia , Hamartoma/patologia , Humanos , Masculino , Cuidados Pré-Operatórios , Lobo Temporal/patologia , Lobo Temporal/fisiopatologia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
OBJECTIVE: To test the hypothesis that seizure origin may be predicted from scalp-recorded electroencephalographic interictal epileptiform patterns that occur exclusively or preponderantly over a single focal region. PATIENTS AND METHODS: Fifty-nine of 98 patients (>=16 years old) with intractable epilepsy who underwent sphenoidal/scalp electroencephalographic video monitoring were identified as having interictal epileptiform discharges preponderantly (>=75% of all discharges) or exclusively over a single unilateral region (basal-temporal, midposterior temporal, frontopolar, superior frontal, central). Ictal recordings in 48 patients could be interpreted as demonstrating focal origins, and the ictal findings were compared with the interictal findings. Eleven patients had uninterpretable ictal recordings or no seizures during monitoring and were not further considered. RESULTS: All seizures arose from the expected region in 39 of the 48 patients (Fisher's exact test, P<.001). Interictal discharges occurred exclusively over a single region in 23 of the 48 patients, and all seizures arose from the expected region in 22 of the 23 patients (P<.001). Seventeen patients among this group of 23 had exclusively unilateral basal-temporal discharges, and all seizures arose from the expected side, with the exception of one seizure that arose from the opposite side in one patient, with her other seizure arising from the expected side (P<.001). All seizures arose from the expected region in three patients who exhibited all interictal discharges arising from a single superior frontal region, in two patients with discharges only over a single midposterior temporal region, and in one patient with exclusively unilateral frontopolar discharges. CONCLUSIONS: Interictal discharges that demonstrate a consistent unilateral focal preponderance over a single region, regardless of location, generally predict seizure origin. If the discharges are exclusive to a single region, there is a greater than 95% probability that all recorded seizures will originate from the expected region.
Assuntos
Epilepsia/fisiopatologia , Adolescente , Adulto , Idoso , Eletroencefalografia , Epilepsia/patologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-IdadeRESUMO
Two families with a point mutation in mtDNA associated with myoclonic epilepsy and ragged-red fiber disease showed pronounced clinical heterogeneity. The mothers of the two families had adult-onset myopathy with ragged-red fibers, partial deficiency of cytochrome c oxidase, and sensory neuropathy. Members of the first family had variable clinical features of progressive ataxic-myoclonic encephalomyopathy and of the other family, primarily adult-onset myopathy. There was a point mutation from A to G at nucleotide pair 8344 located in the tRNALys gene of the mtDNA of all patients tested, three in Family 1, and the mother of Family 2. This clinical heterogeneity may reflect the effects of varying proportions of mutant and wild-type mtDNA in the different organ systems in each individual.
Assuntos
DNA Mitocondrial/genética , Síndrome MERRF/genética , Mutação Puntual , RNA de Transferência de Lisina/genética , Adenina , Adulto , Sequência de Bases , Biópsia , Citrato (si)-Sintase/metabolismo , Deficiência de Citocromo-c Oxidase , DNA Mitocondrial/isolamento & purificação , Complexo IV da Cadeia de Transporte de Elétrons/metabolismo , Família , Feminino , Guanina , Humanos , Síndrome MERRF/enzimologia , Síndrome MERRF/patologia , Masculino , Pessoa de Meia-Idade , Mitocôndrias Musculares/enzimologia , Dados de Sequência Molecular , Músculos/enzimologia , Músculos/patologia , NADH Desidrogenase/metabolismo , Oligodesoxirribonucleotídeos , Linhagem , Fenótipo , Reação em Cadeia da Polimerase/métodos , Succinato Desidrogenase/metabolismoRESUMO
The present case study documents an unprecedented opportunity for correlative investigation of brain structure and function by quantitatively investigating the basilar dendritic systems of supragranular pyramidal cells in several cortical areas from a subject who had undergone electrical stimulation mapping 2 years prior to death. Electrical stimulation mapping results provided valuable functional information about the cortical areas removed for postmortem histological analysis. Morphometric analyses distinguished between proximal (first, second, and third order) and ontogenetically later developing distal (fourth order and above) basilar dendritic branches. In general, perisylvian language association stimulation sites (classical Wernicke's and Broca's areas) were characterized by different dendritic patterns than motor strip sites. In primary motor strip tissue blocks, proximal segments were longer than distal segments. In "higher order" elaborative cortical zones, distal segments were longer than proximal segments. Proximal segments outnumbered distal segments in primary motor zones, but the numerical difference between proximal and distal segments was reduced in the association areas. Finally, fourth order segments had significantly more dendritic spines than third order segments in all sites. These dendritic findings suggest a somewhat later ontogenetic development in classical Broca's and Wernicke's areas than in primary motor cortex.
Assuntos
Córtex Cerebral/anatomia & histologia , Dendritos/ultraestrutura , Fala/fisiologia , Adulto , Mapeamento Encefálico , Contagem de Células , Córtex Cerebral/fisiologia , Dendritos/fisiologia , Estimulação Elétrica , Lobo Frontal/anatomia & histologia , Lobo Frontal/fisiologia , Lateralidade Funcional , Humanos , Masculino , Córtex Motor/fisiologia , Pia-Máter , Lobo Temporal/anatomia & histologia , Lobo Temporal/fisiologiaRESUMO
This article reviews the results of surgical treatment of temporal lobe epilepsy based on retrospective reviews: more recent surveys from 91 centers on the outcomes from the surgical treatment of epilepsy and preliminary data from the authors' institution's 5-year retrospective review of nearly 100 surgical patients matched to medically treated epileptics. Surgical outcomes from resections in other areas, including extratemporal resections, and the efficacy of lesionectomy versus epilepsy surgery for structural lesions are detailed elsewhere in this issue.
Assuntos
Epilepsia do Lobo Temporal/cirurgia , Lobo Temporal/cirurgia , Humanos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Gabapentin was studied as an open-label 'add-on' antiepileptic drug in 35 patients with partial seizures. Follow-up at 6 months, 12 months, 18 months, and 24 months is reported. There was a trend toward improvement in simple (SPS) and complex partial seizures with it reaching significance for SPS at 12 and 24 months and for the weighted combination of seizures at 3 months. Five of nine patients were subsequently successfully converted to gabapentin monotherapy. Of those five, one is now seizure free and three are significantly improved since baseline. One remains with unchanged seizure frequency compared to baseline, but is experiencing less toxicity than at that time. This long-term observation suggests that the short-term effect demonstrated in blinded studies continues and that indeed some patients with refractory epilepsy can be maintained on gabapentin alone. Based on these findings, double-blind monotherapy trials of this drug are presently being conducted.
Assuntos
Acetatos/uso terapêutico , Aminas , Anticonvulsivantes/uso terapêutico , Ácidos Cicloexanocarboxílicos , Epilepsias Parciais/tratamento farmacológico , Ácido gama-Aminobutírico , Acetatos/efeitos adversos , Adolescente , Adulto , Anticonvulsivantes/efeitos adversos , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Gabapentina , Humanos , Masculino , Pessoa de Meia-Idade , Projetos de Pesquisa , Fatores de TempoAssuntos
Epilepsia/cirurgia , Adulto , Neoplasias Encefálicas/cirurgia , Criança , Corpo Caloso/cirurgia , Epilepsia/diagnóstico , Epilepsia/tratamento farmacológico , Glioma/cirurgia , Humanos , Neuroblastoma/cirurgia , Testes Neuropsicológicos , Complicações Pós-Operatórias , Lobo Temporal/cirurgiaAssuntos
Anticonvulsivantes/administração & dosagem , Epilepsias Parciais/tratamento farmacológico , Epilepsia Generalizada/tratamento farmacológico , Complicações na Gravidez/tratamento farmacológico , Estado Epiléptico/tratamento farmacológico , Adulto , Anticonvulsivantes/toxicidade , Criança , Relação Dose-Resposta a Droga , Epilepsias Parciais/classificação , Epilepsias Parciais/diagnóstico , Epilepsia Generalizada/classificação , Epilepsia Generalizada/diagnóstico , Feminino , Humanos , Gravidez , Complicações na Gravidez/diagnóstico , Estado Epiléptico/diagnósticoRESUMO
Cortical resection surgery for epilepsy is costly, involves risk, and does not result in significant seizure relief in a number of patients. Therefore, it is important to develop methods which will as accurately as possible identify in advance those persons who will or will not be helped by this procedure. From a review of the literature and from a presentation of original data, it is concluded that psychological/neuropsychological variables are valid predictors of cessation of seizures following surgery but that they are only infrequently used. A multidisciplinary, multivariate statistical approach, using EEG findings and psychological/neuropsychological variables in combination, provides the most accurate predictions which are superior to those derived from using either EEG variables or psychological/neuropsychological variables alone. This approach also avoids much of the predictive instability encountered when single variables are evaluated. Since psychological/neuropsychological variables are obtained at low cost and are non-invasive, further evaluation of their role as predictors of seizure relief following surgery is needed.
Assuntos
Dano Encefálico Crônico/cirurgia , Epilepsia/cirurgia , Testes Neuropsicológicos , Equipe de Assistência ao Paciente , Complicações Pós-Operatórias/diagnóstico , Adolescente , Adulto , Dano Encefálico Crônico/psicologia , Mapeamento Encefálico , Córtex Cerebral/cirurgia , Eletroencefalografia , Epilepsia/psicologia , Humanos , Exame Neurológico , Complicações Pós-Operatórias/psicologiaAssuntos
Anticonvulsivantes/administração & dosagem , Epilepsia/diagnóstico , Terminologia como Assunto , Adulto , Anticonvulsivantes/farmacocinética , Anticonvulsivantes/toxicidade , Criança , Diagnóstico Diferencial , Relação Dose-Resposta a Droga , Esquema de Medicação , Eletroencefalografia , Epilepsia/classificação , Epilepsia/tratamento farmacológico , Epilepsia/etiologia , HumanosRESUMO
In an effort to determine the long-term efficacy of surgical therapy for epilepsy, a control group of patients was identified. Both the surgically treated and non-surgical groups were evaluated before and after 5- or 10-year follow-ups for seizure frequency in the preceding 2 years. To date 39 patients have had bona fide partial seizures, with or without secondary generalization, and EEGs with focal epileptiform patterns. Prior to first evaluation, these patients had had seizures for an average of 10 years and were treated with an average of 54 AEDs with documented therapeutic serum levels in most; one-third of the patients participated in experimental studies. After treatment for another 5 years with an average of 2.5 AEDs or 10 years with an average of 4.0 AEDs, no one was seizure free. Fifteen percent had a 75% decrease in seizure frequency and 85% continued to have no significant improvement in seizure control. Thus despite vigorous treatment, these patients who might have been considered surgical candidates continued to have uncontrolled seizures.
Assuntos
Anticonvulsivantes/uso terapêutico , Epilepsias Parciais/tratamento farmacológico , Adolescente , Adulto , Encéfalo/efeitos dos fármacos , Encéfalo/fisiopatologia , Encéfalo/cirurgia , Criança , Pré-Escolar , Eletroencefalografia/efeitos dos fármacos , Epilepsias Parciais/fisiopatologia , Epilepsias Parciais/cirurgia , Epilepsia Parcial Complexa/tratamento farmacológico , Epilepsia Parcial Complexa/fisiopatologia , Epilepsia Parcial Complexa/cirurgia , Epilepsia Generalizada/tratamento farmacológico , Epilepsia Generalizada/fisiopatologia , Epilepsia Generalizada/cirurgia , Epilepsia Tônico-Clônica/tratamento farmacológico , Epilepsia Tônico-Clônica/fisiopatologia , Epilepsia Tônico-Clônica/cirurgia , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Masculino , Exame Neurológico/efeitos dos fármacos , Complicações Pós-Operatórias/fisiopatologiaRESUMO
Distinguishing characteristics of seizures of frontal origin have not been clearly delineated. We describe a case of seizures of proven fronto-orbital origin to provide further definition of characteristics of seizures arising in that lobe. A 36-year-old man had medically intractable seizures since age 8 years. Clinically the seizures were stereotyped, with cessation of activity followed by turning of head and body to the right and then by struggling, kicking, and vocalizations indicating fear. Total seizure duration was approximately 30 s, with an apparent abrupt return of consciousness. The interictal scalp EEGs were similar to those of primary generalized epilepsy, with bisynchronous though asymmetric epileptiform activity anteriorly. Ictal scalp recordings were not localizing. Recordings from bilateral frontal and temporal subdural electrodes showed an electrical focus in the right fronto-orbital region which was confirmed by electrocorticography (ECoG) at the time of craniotomy. The right fronto-orbital cortex was resected and on pathologic examination showed gliotic tissue and intracytoplasmic neuronal inclusions of periodic acid-Schiff (PAS)-positive granules consistent with lipofuscinosis. The patient has remained seizure-free for 6 years after operation.