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1.
Chem Biodivers ; 10(4): 703-10, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23576356

RESUMO

Three new triterpene glucosides, named congmuyenosides C-E (1-3, resp.), along with four known ones, were isolated from an EtOH extract of Aralia elata (Miq.) Seem. leaves. The structures of the new compounds were identified as 3-O-{ß-D-glucopyranosyl-(1→3)-ß-D-glucopyranosyl-(1→3)-[ß-D-glucopyranosyl-(1→2)]-ß-D-glucopyranosyl}caulophyllogenin (1), 3-O-{ß-D-glucopyranosyl-(1→3)-ß-D-glucopyranosyl-(1→3)-[ß-D-glucopyranosyl-(1→2)]-ß-D-glucopyranosyl}hederagenin 28-O-ß-D-glucopyranosyl ester (2), 3-O-{ß-D-glucopyranosyl-(1→3)-ß-D-glucopyranosyl-(1→3)-[ß-D-glucopyranosyl-(1→2)]-ß-D-glucopyranosyl}echinocystic acid 28-O-ß-D-glucopyranosyl ester (3) on the basis of spectral analyses, including MS, (1) H-NMR, (13) C-NMR, DEPT, HSQC, HMBC, NOESY, and HSQC-TOCSY experiments. All isolates obtained were evaluated for their cytotoxic activities against three human tumor cell lines (HepG2, SKOV3, and A549). Compound 3 showed significant cytotoxicity against A549 cell line (IC50 9.9±1.5 µM).


Assuntos
Aralia/química , Glucosídeos/química , Triterpenos/química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Glucosídeos/isolamento & purificação , Glucosídeos/toxicidade , Células Hep G2 , Humanos , Espectroscopia de Ressonância Magnética , Conformação Molecular , Folhas de Planta/química , Triterpenos/isolamento & purificação , Triterpenos/toxicidade
2.
No Shinkei Geka ; 33(4): 351-5, 2005 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-15830541

RESUMO

The purpose of this investigation was to analyze three-dimensional images of the optic nerve obtained by magnetic resonance angiography (MRA) in cases of anterior communicating artery aneurysm and craniopharingioma. Four ruptured anterior communicating artery aneurysms, five non-ruptured anterior communicating artery aneurysms and two craniopharingiomas were examined. The images were taken using MR/i Hispeed Plus 1.5T Infinity version, and analyzed by Advantage Work station AW4.1. The routine MR imaging parameters are shown in Table. The imaging time was about 10 minutes. Analysis was made by reformation of images parallel to the optic nerve obtained from the original MRA images. The optic nerve and brain tumor were traced with paintbrush from one sheet to another of the reformed images after subtraction of the blood vessels around the anterior communicating artery in these reformed images, and then three-dimensional images were constructed. Three-dimensional images of the blood vessels were reconstructed from MIP (maximum intensity projection) images using the threshold method. The optic nerve and anterior communicating arterial aneurysm or brain tumor were both observed in the overlapped 3D-SSD (shaded surface display) images. The analysis time was about 15 minutes. Three-dimensional images of the optic nerve and anterior communicating artery aneurysm or brain tumor were able to be made in all cases. As a preoperative investigation for anterior communicating artery aneurysm or suprasellar brain tumor, we considered that three-dimensional imaging of the optic nerve is useful in the operative approach because the optic nerve acts as a merkmal for the anterior communicating aneurysm or brain tumor.


Assuntos
Craniofaringioma/diagnóstico , Imageamento Tridimensional , Aneurisma Intracraniano/diagnóstico , Angiografia por Ressonância Magnética , Nervo Óptico/patologia , Neoplasias Hipofisárias/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Aneurisma Roto/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
3.
No Shinkei Geka ; 32(2): 121-5, 2004 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-15031972

RESUMO

The purpose of this investigation was to study the incidence rate of rupture with respect to the site and size of multiple cerebral aneurysms that include both ruptured and unruptured aneurysms. Site and size were investigated in 58 cases of this type of multiple cerebral aneurysm. All cerebral aneurysms were examined with MR angiography, 3D-CT angiography and digital subtraction angiography, as well as seeing measured using 3D-CT or digital subtraction angiography. As regards the site of the 58 ruptured cerebral aneurysms under study, 18 were internal carotid aneurysms (C2 or C3: 4 cases, IC-PC: 12 cases, IC-ancho.: 1 case, IC terminal: 1 case), 25 were anterior communicating aneurysms, 10 were middle cerebral aneurysms, 4 were anterior cerebral aneurysms and 1 case was a VA-PICA aneurysm. The ruptured internal carotid aneurysms were 4.0-21.0 mm in size, the anterior communicating aneurysms were 1.8-13 mm, the middle cerebral aneurysms were 2.0-21.3 mm, the anterior cerebral aneurysms were 3.2-9.1 mm, and the VA-PICA aneurysm was 4.4 mm. The sites of the 89 unruptured cerebral aneurysms break down as follows: 29 were internal carotid aneurysms (C2 or C3: 4 cases, IC-PC: 10 cases, IC-ancho.: 10 cases, IC terminal: 5 cases), 18 were anterior communicating aneurysms, 34 were middle cerebral aneurysms, and there were 5 cases of posterior circulation aneurysm. In size, the unruptured internal carotid aneurysms were 1.0-18.3 mm, the anterior communicating aneurysms were 1.0-6.5 mm, the middle cerebral aneurysms were 1.0-10.3 mm, the anterior cerebral aneurysms were 1.0-3.3 mm, and the posterior circulation aneurysms were 2.2-17.3 mm. Out of 58 ruptured cerebral aneurysms, 44 were of the largest size category, and 53 (91.4%) were in the largest size category and/or anterior communicating aneurysms. The accumulated incidence rate of rupture of anterior communicating aneurysms rose suddenly upon reaching 2 mm in size, and after reaching 3 mm, these aneurysms accounted for a nearly uniform 55%-60% of the incidence rate of rupture. The accumulated incidence rate of rupture of IC-PC aneurysms rose drastically at 4 mm in size with the data describing a parabolic slope when graphed. IC-PC aneurysms represented a uniform 55% of the incidence rate of rupture after reaching 8 mm in size. The accumulated incidence rate of rupture of middle cerebral aneurysms rose in a gently sloping parabola beginning at 4 mm, and stabilized at 20% upon reaching 10 mm. These results suggest that each site is associated with a characteristic size and rate of aneurismal rupture. Special attention should thus be paid to large and anterior communicating aneurysms when operating on multiple cerebral aneurysms.


Assuntos
Aneurisma Roto/epidemiologia , Aneurisma Roto/patologia , Artérias Cerebrais/patologia , Aneurisma Intracraniano/epidemiologia , Aneurisma Intracraniano/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Aneurisma Roto/diagnóstico , Diagnóstico por Imagem , Feminino , Humanos , Incidência , Aneurisma Intracraniano/diagnóstico , Masculino , Pessoa de Meia-Idade , Ruptura Espontânea
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