The Nanoscale Structure and Stability of Organic Photovoltaic Blends Processed with Solvent Additives.

Controlling the nanomorphology in bulk heterojunction photoactive blends is crucial for optimizing the performance and stability of organic photovoltaic (OPV) technologies. A promising approach is to alter the drying dynamics and consequently, the nanostructure of the blend film using solvent additives such as 1,8-diiodooctane (DIO). Although this approach is demonstrated extensively for OPV systems incorporating fullerene-based acceptors, it is unclear how solvent additive processing influences the morphology and stability of nonfullerene acceptor (NFA) systems. Here, small angle neutron scattering (SANS) is used to probe the nanomorphology of two model OPV systems processed with DIO: a fullerene-based system (PBDB-T:PC71BM) and an NFA-based system (PBDB-T:ITIC). To overcome the low intrinsic neutron scattering length density contrast in polymer:NFA blend films, the synthesis of a deuterated NFA analog (ITIC-d52) is reported. Using SANS, new insights into the nanoscale evolution of fullerene and NFA-based systems are provided by characterizing films immediately after fabrication, after thermal annealing, and after aging for 1 year. It is found that DIO processing influences fullerene and NFA-based systems differently with NFA-based systems characterized by more phase-separated domains. After long-term aging, SANS reveals both systems demonstrate some level of thermodynamic induced domain coarsening.

Comparing Radar-Based Breast Imaging Algorithm Performance with Realistic Patient-Specific Permittivity Estimation.

Radar-based breast imaging has shown promise as an imaging modality for early-stage cancer detection, and clinical investigations of two commercial imaging systems are ongoing. Many imaging algorithms have been proposed, which seek to improve the quality of the reconstructed microwave image to enhance the potential clinical decision. However, in many cases, the radar-based imaging algorithms have only been tested in limited numerical or experimental test cases or with simplifying assumptions such as using one estimate of permittivity for all patient test cases. In this work, the potential impact of patient-specific permittivity estimation on algorithm comparison is highlighted using representative experimental breast phantoms. In particular, the case studies presented help show that the permittivity estimate can impact the conclusions of the algorithm comparison. Overall, this work suggests that it is important that imaging algorithm comparisons use realistic test cases with and without breast abnormalities and with reconstruction permittivity estimation.

Sensitivity and Specificity Estimation Using Patient-Specific Microwave Imaging in Diverse Experimental Breast Phantoms.

Many new clinical investigations of microwave breast imaging have been published in recent years. Trials with over one hundred participants have indicated the potential of microwave imaging to detect breast cancer, with particularly encouraging sensitivity results reported from women with dense breasts. The next phase of clinical trials will involve larger and more diverse populations, including women with no breast abnormalities or benign breast diseases. These trials will need to address clinical efficacy in terms of sensitivity and specificity. A number of challenges exist when using microwave imaging with broad populations: 1) addressing the substantial variance in breast composition observed in the population and 2) achieving high specificity given differences between individuals. This paper analyses these challenges using a diverse phantom set which models the variance in breast composition and tumor shape and size seen in the population. The data show that the sensitivity of microwave breast imaging in breasts of differing density can suffer if patient-specific beamforming is not used. Moreover, the results suggest that achieving high specificity in dense breasts may be difficult, but that patient-specific beamforming does not adversely affect the expected specificity. In summary, this paper finds that patient-specific beamforming has a tangible impact on expected sensitivity in experimental cases and that achieving high specificity in dense breasts may be challenging.

Diagnosing Breast Cancer with Microwave Technology: remaining challenges and potential solutions with machine learning.

Currently, breast cancer often requires invasive biopsies for diagnosis, motivating researchers to design and develop non-invasive and automated diagnosis systems. Recent microwave breast imaging studies have shown how backscattered signals carry relevant information about the shape of a tumour, and tumour shape is often used with current imaging modalities to assess malignancy. This paper presents a comprehensive analysis of microwave breast diagnosis systems which use machine learning to learn characteristics of benign and malignant tumours. The state-of-the-art, the main challenges still to overcome and potential solutions are outlined. Specifically, this work investigates the benefit of signal pre-processing on diagnostic performance, and proposes a new set of extracted features that capture the tumour shape information embedded in a signal. This work also investigates if a relationship exists between the antenna topology in a microwave system and diagnostic performance. Finally, a careful machine learning validation methodology is implemented to guarantee the robustness of the results and the accuracy of performance evaluation.

Parameter Search Algorithms for Microwave Radar-Based Breast Imaging: Focal Quality Metrics as Fitness Functions.

Inaccurate estimation of average dielectric properties can have a tangible impact on microwave radar-based breast images. Despite this, recent patient imaging studies have used a fixed estimate although this is known to vary from patient to patient. Parameter search algorithms are a promising technique for estimating the average dielectric properties from the reconstructed microwave images themselves without additional hardware. In this work, qualities of accurately reconstructed images are identified from point spread functions. As the qualities of accurately reconstructed microwave images are similar to the qualities of focused microscopic and photographic images, this work proposes the use of focal quality metrics for average dielectric property estimation. The robustness of the parameter search is evaluated using experimental dielectrically heterogeneous phantoms on the three-dimensional volumetric image. Based on a very broad initial estimate of the average dielectric properties, this paper shows how these metrics can be used as suitable fitness functions in parameter search algorithms to reconstruct clear and focused microwave radar images.