Bibliometric Analysis of Global Scientific Production on COVID-19 and Vaccines.

This bibliometric analysis aims to analyze the global scientific production of COVID-19 and vaccines. First, a search for scientific articles was performed using the advanced query in the Web of Science™ database, more precisely in its core collection, on 18 February 2023. Data from 7754 articles were analyzed using the Bibliometrix R package and the Biblioshiny application. The evaluated articles were published mainly in 2022 (60%). The scientific journals that published the most about COVID-19 and vaccines were "Vaccines", "Vaccine" and "Human Vaccines & Immunotherapeutics". The University of Oxford was the most productive institution, with the authors of the articles mainly originating from the United States, China and the United Kingdom. The United States, despite having carried out the most significant number of collaborations, published mainly with local researchers. The 15 most cited articles and the KeyWords Plus™ evidenced the focus of the published articles on the safety and efficacy of vaccines against COVID-19, as well as on the evaluation of vaccine acceptance, more specifically on vaccine hesitancy. Research funding came primarily from US government agencies.

Inibidores da Janus Kinase na alopecia areata: uma nova possibilidade terapêutica / Janus Kinase inhibitors in alopecia areata: new terapeutic possibilities

Objetivo: Analisar as produções científicas sobre a efetividade dos inibidores da enzima Janus-Kinase (iJAK) no tratamento da Alopecia Areata. Métodos: Realizou-se uma revisão integrativa de artigos publicados no período de 2015 a 2020, nos idiomas inglês, português e espanhol que contemplassem a temática. A busca na literatura foi realizada por meio dos bancos de dados da Biblioteca Virtual em Saúde e Pubmed, utilizando-se a combinação dos descritores "Alopecia areata" e "tratamento". Resultados: A partir da análise das publicações e considerando os critérios de inclusão pré-estabelecidos, foram selecionados vinte e um artigos, de um total de mil quatrocentos e cinquenta e oito publicações. Considerações Finais: Diante dos resultados, os iJAK são drogas favoráveis e de crescente importância no arsenal do médico dermatologista no tratamento da Alopecia Areata. Seus efeitos colaterais, quando presentes, foram transitórios e sem grande morbidade. Porém, estudos prospectivos e comparativos são necessários para ratificar a eficácia e segurança desses medicamentos a longo prazo no tratamento da Alopecia Areata(AU).

Objective:Analyze scientific productions on the effectiveness of Janus-Kinase (iJAK) enzyme inhibitors in the treatment of Alopecia Areata. Methods:An integrative review of articles published from 2015 to 2020, in English, Portuguese and Spanish, was carried out. The literature was searched through the Virtual Health Library databases and Pubmed, using the combination of the descriptors "Alopecia areata" and "treatment". Results:From the analysis of publications and considering pre-established inclusion criteria, twenty-one articles were selected from a total of one thousand four hundred and fifty-eight publications. Final Considerations:In view of the results, the iJAK are favorable drugs and of growing importance in the arsenal of the dermatologist in the treatment of Alopecia Areata. Their side effects, when present, were transitory and without great morbidity. However, prospective and comparative studies are necessary to confirm the efficacy and long-term safety of these drugs in the treatment of Alopecia Areata(AU).