RESUMO
The need for efficient and cost-effective cholera vaccine hasn't lost its actuality in view of the emergence of new strains leading to severe clinical forms of cholera and capable to replace strains of the seventh.cholera pandemic, and in connection with the threat of cholera spreading beyond the borders of endemic countries. In this review data from literature sources are presented about the use of outer membrane proteins, vesicles, cell ghosts of the cholera causative agent in specific prophylaxis and diagnostics of the disease.
Assuntos
Proteínas da Membrana Bacteriana Externa , Estruturas da Membrana Celular , Vacinas contra Cólera , Cólera , Vibrio cholerae , Proteínas da Membrana Bacteriana Externa/química , Proteínas da Membrana Bacteriana Externa/imunologia , Proteínas da Membrana Bacteriana Externa/metabolismo , Estruturas da Membrana Celular/química , Estruturas da Membrana Celular/imunologia , Estruturas da Membrana Celular/metabolismo , Cólera/diagnóstico , Cólera/epidemiologia , Cólera/imunologia , Cólera/metabolismo , Vacinas contra Cólera/química , Vacinas contra Cólera/imunologia , Vacinas contra Cólera/metabolismo , Humanos , Vibrio cholerae/química , Vibrio cholerae/imunologia , Vibrio cholerae/metabolismoRESUMO
Recently, due to spread of dangerous and especially dangerous infections much attention is given to development of complex approaches to their prophylaxis and therapy. Data on use of immune modulators, cytokines, probiotics, preparations of plant origin for non-specific prophylaxis of especially dangerous infections are analyzed in the review, and expediency of their combined use with specific and emergency prophlaxis of these diseases is evaluated.
