1.
Int J Surg Pathol
; 29(3): 289-293, 2021 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32608312
RESUMO
E-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123-targeted therapies are becoming available.
Assuntos
Antígenos CD/análise , Medula Óssea/patologia , Caderinas/análise , Células Dendríticas/patologia , Neoplasias Hematológicas/diagnóstico , Mielofibrose Primária/patologia , Transformação Celular Neoplásica , Diagnóstico Diferencial , Evolução Fatal , Feminino , Neoplasias Hematológicas/patologia , Humanos , Leucemia Eritroblástica Aguda/diagnóstico , Leucemia Eritroblástica Aguda/patologia , Pessoa de Meia-Idade , Mielofibrose Primária/diagnóstico
2.
Lancet
; 380(9848): 1202, 2012 Sep 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23021289