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1.
Chemistry ; 26(66): 15051, 2020 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-33174290

RESUMO

Invited for the cover of this issue is the group of Dirk Menche at the University of Bonn. The image depicts the natural product leupyrrin A1 and a synthetic leupylog in balance on an IC50 weighing scale. Read the full text of the article at 10.1002/chem.202002622.

2.
Chemistry ; 26(66): 15074-15078, 2020 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-32608026

RESUMO

Leupyrrins are highly potent antifungal agents. A structure-activity-relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the discovery of highly potent but drastically simplified leupylogs that incorporate a stable and readily available aromatic side chain. For their synthesis a concise strategy is described that enables a short and versatile access.

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