Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald-Hartwig and Suzuki-Miyaura cross-coupling reactions.

This work presents the simple synthesis of a green and novel Palladium based magnetic nanocatalyst with effective catalytic properties and reusability. These heterogeneous catalysts were prepared by the anchoring of Pd(0) on the surface of ZrFe2O4 MNPs coated with a di-substituted adenine (Ade) compound as a green linker. The as-synthesized ZrFe2O4@SiO2@Ade-Pd MNPs were methodically characterized over different physicochemical measures like VSM, EDX, Map, SEM, TEM, ICP, and FT-IR analysis. The catalytic activity of ZrFe2O4@SiO2@Ade-Pd was carefully examined for the room-temperature Carbon-Carbon coupling reaction in acetonitrile as a solvent. It is worth noting that the synthesized solid catalyst can be easily recovered with a bar magnet and reused for five cycles without decrease of catalytic activity.

The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles.

Autoimmune diseases are complex, chronic inflammatory conditions initiated by the loss of immunological tolerance to self-antigens. Nowadays, there is no effective and useful therapy for autoimmune diseases, and the existing medications have some limitations due to their nonspecific targets and side effects. During the last few decades, it has been established that mesenchymal stem cells (MSCs) have immunomodulatory functions. It is proposed that MSCs can exert an important therapeutic effect on autoimmune disorders. In parallel with these findings, several investigations have shown that MSCs alleviate autoimmune diseases. Intriguingly, the results of studies have demonstrated that the effective roles of MSCs in autoimmune diseases do not depend on direct intercellular communication but on their ability to release a wide spectrum of paracrine mediators such as growth factors, cytokines and extracellular vehicles (EVs). EVs that range from 50 to 5,000 nm were produced by almost any cell type, and these nanoparticles participate in homeostasis and intercellular communication via the transfer of a broad range of biomolecules such as modulatory proteins, nucleic acids (DNA and RNA), lipids, cytokines, and metabolites. EVs derived from MSCs display the exact properties of MSCs and can be safer and more beneficial than their parent cells. In this review, we will discuss the features of MSCs and their EVs, EVs biogenesis, and their cargos, and then we will highlight the existing discoveries on the impacts of EVs from MSCs on autoimmune diseases such as multiple sclerosis, arthritis rheumatic, inflammatory bowel disease, Type 1 diabetes mellitus, systemic lupus erythematosus, autoimmune liver diseases, Sjögren syndrome, and osteoarthritis, suggesting a potential alternative for autoimmune conditions therapy.

A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity.

Aging is a biological process determined through time-related cellular and functional impairments, leading to a decreased standard of living for the organism. Recently, there has been an unprecedented advance in the aging investigation, especially the detection that the rate of senescence is at least somewhat regulated via evolutionarily preserved genetic pathways and biological processes. Hematopoietic stem cells (HSCs) maintain blood generation over the whole lifetime of an organism. The senescence process influences many of the natural features of HSC, leading to a decline in their capabilities, independently of their microenvironment. New studies show that HSCs are sensitive to age-dependent stress and gradually lose their self-renewal and regeneration potential with senescence. MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally inhibit translation or stimulate target mRNA cleavage of target transcripts via the sequence-particular connection. MiRNAs control various biological pathways and processes, such as senescence. Several miRNAs are differentially expressed in senescence, producing concern about their use as moderators of the senescence process. MiRNAs play an important role in the control of HSCs and can also modulate processes associated with tissue senescence in specific cell types. In this review, we display the contribution of age-dependent alterations, including DNA damage, epigenetic landscape, metabolism, and extrinsic factors, which affect HSCs function during aging. In addition, we investigate the particular miRNAs regulating HSCs senescence and age-associated diseases. Video Abstract.

Exploring tourism business model importance with the emergence of blockchain system: directions for tourism industry of China.

The study aims to explore the importance of the tourism business model with the emergence of the blockchain platform in China. The study focused on the importance of the tourism business model of china, studied the need to improve the tourism business infrastructure, and traced the value of the blockchain system in the tourism industry of china. For this, the researchers used a semi-structured interview approach to conduct a qualitative research design. About nine Chinese tourism and travel industry experts were interwar after initial screening using purposive sampling techniques. The respondents' responses were analyzed by applying a thematic analysis approach, and by this, the researchers extracted the main themes on study topicality to fill the gap in the literature. The study's novelty is in its topicality and context, for which it also provides viable, practical directions for stakeholders.

Innovative application of new media in visual communication design and resistance to innovation.

It has become essential to create and apply new media in visual communication design due to social media existence. This study aims to investigate the role of innovative applications of new media in visual communication design in educational institutions. Traditional media design in visual communication lacks to disseminate information more effectively, which requires innovative change. Therefore, this study attempts to highlight the role of innovative application of new media in visual communication by considering visual expression design with information technology (IT), flexible layout, diversified modes of transmission, and interactivity of integration. For this purpose, this study adopted a quantitative research approach in which a cross-sectional research design is followed. A questionnaire survey is carried out to collect data from educational institutions in China. Partial Least Square-Structural Equation Modeling (PLS-SEM) is used for data analysis. Results of the study indicated that innovative applications of new media have central importance in visual communication. However, resistance to innovative change has a negative role in the relationship between innovative applications of new media and visual communication design. Results of the study highlighted that visual expression design with IT, flexible layout, diversified modes of transmission, and interactivity of integration have a positive effect on visual communication design. Therefore, among the educational intuitions of China, implementing innovative applications related to the new media can lead to visual communication design. The results of this study provided several insights for the practitioners to promote communication methods among educational institutions.

Assessing the management student's entrepreneurial intentions: Role of entrepreneurship education and technology transfer.

Entrepreneurship education is considered as an important way to influence the competitiveness of any country or industry. Therefore, entrepreneurship education provides opportunities to progress to a more competitive educational environment. This paper examines the impact of students' entrepreneurship education in China on their entrepreneurial intentions. Perceived entrepreneurial capacity, education in entrepreneurship, and attitudes toward entrepreneurship are all factors in the model developed to predict entrepreneurial intention. Structured equation modeling (SEM) is being used to test 98 management students from various universities in China. The findings show that there is statistically significant and positive relationship among entrepreneurship learning, entrepreneurial attitude, entrepreneurship education, and management students' entrepreneurial intention. Perceived behavioral control and perceive social rule significantly improve management students' entrepreneurial intention. Moreover, technology transfer correlates statistically with students' entrepreneurial intentions. Thus, universities are being encouraged to offer entrepreneurial training modules to increase their students' entrepreneurial intent.