[Structure and dynamics of depressive disorders in patients with a new coronavirus infection]. / Struktura i dinamika depressivnykh rasstroistv u patsientok, perenesshikh novuyu koronavirusnuyu infektsiyu (COVID-19).

OBJECTIVE: To analyze the dynamics of depressive disorders in patients who underwent COVID-19. MATERIAL AND METHODS: The study included female patients (n=30) with mean age 35.4±3.0 years, who received inpatient treatment of depressive spectrum symptoms in accordance with ICD-10 rubrics F31-F34 and who have undergone COVID-19 (U04.9, U07.1, U07.2). Clinical-psychopathological and statistical methods were used. RESULTS: Among all patients, who underwent inpatient treatment for affective disorders, the most common symptoms were: low mood (96.7%), anxiety (83.3%), decreased interest in daily activities (40%), loss of appetite (36.7%). In patients who have had depressive symptoms before COVID-19, an increase in the number of affective spectrum symptoms (suicidal thoughts - 83.3%), as well as in asthenic manifestations in the form of increased fatigue (60%), sleep disorders (73.3%), feelings of fatigue, weakness (60%), emotional lability (40%). CONCLUSION: In patients with depressive disorders who underwent COVID-19, hypothymia is most often accompanied by anxiety, suicidal thoughts, as well as asthenic manifestations in the form of fatigue, sleep disturbances, and emotional lability. An increase in the number of asthenic spectrum symptoms in patients with depressive disorders may indicate a possible link between COVID-19 and affective pathology. The impact of coronavirus infection on the structure and dynamics of depressive disorders requires further study, taking into account the severity of affective symptoms, the impact of psychopharmacotherapy, and the severity of the infectious disease.

[Predictors of suicidal behaviour in adolescents with depressive disorders]. / Prediktory suitsidal'nogo povedeniia u podrostkov s depressivnymi rasstroistvami.

A review of recent publications is devoted to risk factors for suicidal behavior in adolescents with depressive disorders. The authors summarized Russian and international studies on the clinical course of affective disorders, in particular bipolar disorders, their clinical heterogeneity and incompleteness in adolescence. Particular attention is given to the complexity of early identification of predictors of suicidal behavior in depressive disorders due to comprehensiveness of exogenous and endogenous effects characteristic of adolescence. The role of genetic loading for affective disorders, problems of children having parents with affective disorders, social and psychological factors (violence in families, school bullying etc.) and risks of suicidal behavior are described. It is of great significance to investigate premorbid adjustment, subaffective manifestations of disorders in adolescence to predict the trajectory of the disease, its complications in the form of suicidal behavior and opportunities for early intervention.

[The nature of an anticoagulant isolated from peonies in the central zone of Russia]. / K voprosu o prirode antikoagulianta, poluchennogo iz pionov srednei polosy Rossii.

The nature of the anticoagulant isolated from the Chinese peony roots has been determined. Physicochemical analysis (infrared and mass spectroscopy, and polyacrylamide gel electrophoresis) demonstrated the presence of a glycopeptide in Paeonia suffraticosae roots. This glycopeptide shares a structural similarity with heparin.

[Heparin from the meadowsweet (Filipendula ulmaria) and its properties]. / Geparin iz tavolgi viazolistnoi, ego svoistva.

In the present work, the nature of an anticoagulant from Philipendula ulmaria was studied. A method for purification of this anticoagulant was developed. Using diverse methods it was shown that the molecular weight, data on element (sulphur, nitrogen, and hydrogen) content, spectral characteristics in the infrared region of the spectrum, and electrophoretic properties of the product indicate its similarity to heparin of animal origin.

[Psychological profile of personality of patients with bronchial asthma and chronic obstructive bronchitis]. / Psikhologicheskii profil' lichnosti bol'nykh bronkhial'noi astmoi i khronicheskim obstruktivnym bronkhitom.

Psychological personality profiles were evaluated in 87 patients with bronchial asthma and chronic obstructive bronchitis treated by means of acupuncture. The data point to the improvement of psychological state and reduction of pathological types in patients that run parallel with their clinical improvement. The transition from one pathological state to another having a more benign course was also observed.

[Effect of reflexotherapy on the functional state of the sympathoadrenal system in patients with bronchial asthma]. / Vliianie refleksoterapii na funktsional'noe sostoianie simpatiko-adrenalovoi sistemy u bol'nykh bronkhial'noi astmoi.

Activity of sympathoadrenal system in patients with infectious-allergic bronchial asthma treated with reflexotherapy by monitoring alterations in spontaneous and L-DOPA stimulated daily excretion of adrenaline, noradrenaline, dopamine and L-DOPA with urine. Before and after the reflexotherapy course spontaneous excretion of catecholamines and L-DOPA with urine was found to be similar to the physiologically normal level. The test with per oral administration of 250 mg of L-DOPA showed that before the reflexotherapy the course of consumption of L-DOPA was impaired and, hence, the functional state of sympathoadrenal system was altered. The reflexotherapy improved the L-DOPA consumption suggesting normalization of catecholamine metabolism. The data obtained suggest that normalization of sympathoadrenal system activity is one of important effects of the acupuncture therapy.