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2.
Pathologica ; 110(1): 1-2, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-30259907
3.
Cytopathology ; 29(3): 241-246, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29577488

RESUMO

INTRODUCTION: Ectopic thymic tissue can arise as an asymptomatic neck mass, which may be detected on imaging studies. The aim of this study was to determine the incidence of ectopic thymic tissue in paediatric FNAs and to the correlate clinical, radiological and cytomorphological findings. METHODS: FNAs in children with neck and mediastinal lesions performed between January 2012 and July 2016 were reviewed for cases of ectopic thymus. These were then evaluated and correlated with the cytology findings. RESULTS: Of 739 FNAs, 13 (1.8%) cases from 11 patients showed ectopic thymic tissue. The targeted lesions were in the thyroid (n = 7), submandibular region (n = 1), superior mediastinum (n = 1) and paratracheal region (n = 1). The most common indication was for microcalcifications concerning for papillary thyroid carcinoma on ultrasound (n = 6). Imaging findings included fusiform lesions with linear and punctuate bright echoes. The cytology evaluation showed small lymphocytes with discohesive epithelioid cells in most cases, and proteinaceous fluid in the cystic case. There were rare macrophages and Hassall's corpuscles. Flow cytometry and/or immunostains were performed in all cases, supporting thymic origin. CONCLUSION: Ectopic thymic tissue is rarely present as a neck mass or thyroid nodule on FNA biopsy. The ultrasound imaging findings reveal a well-defined fusiform lesion with punctate bright echoes that could be misinterpreted as papillary thyroid carcinoma. The aspirates show a small lymphoid population, immunophenotypically compatible with thymic T-cells, in addition to scattered epithelial cells. Therefore, knowledge of the typical ultrasonographic and cytopathological features can help make a definitive diagnosis and avoid more invasive procedures in paediatric patients.


Assuntos
Timo/patologia , Glândula Tireoide/patologia , Adolescente , Biópsia por Agulha Fina/métodos , Criança , Pré-Escolar , Células Epiteliais/patologia , Feminino , Humanos , Lactente , Masculino , Mediastino/patologia , Câncer Papilífero da Tireoide/patologia , Nódulo da Glândula Tireoide/patologia , Ultrassonografia/métodos
4.
J Digit Imaging ; 30(5): 555-560, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28116576

RESUMO

Digital pathology is becoming technically possible to implement for routine pathology work. At our institution, we have been using digital pathology for second opinion intraoperative consultations for over 10 years. Herein, we describe our experience in converting to a digital pathology platform for primary pathology diagnosis. We implemented an incremental rollout for digital pathology on subspecialty benches, beginning with cases that contained small amounts of tissue (biopsy specimens). We successfully scanned over 40,000 slides through our digital pathology system. Several lessons (both challenges and opportunities) were learned through this implementation. A successful conversion to digital pathology requires pre-imaging adjustments, integrated software and post-imaging evaluations.


Assuntos
Diagnóstico por Imagem/métodos , Processamento de Imagem Assistida por Computador/métodos , Patologia Clínica/métodos , Sistemas de Informação em Radiologia , Telepatologia/métodos , Estudos de Viabilidade , Humanos
5.
BJR Case Rep ; 1(2): 20150002, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-30363177

RESUMO

We report the imaging findings and histopathology of a rare case of sacral hibernoma in a female presenting with right buttock pain while sitting. The lesion was occult on radiographs and CT scan. A small, rounded right S2 lesion was hypointense on T 1 weighted images and hyperintense on short tau inversion-recovery images. It demonstrated homogeneous contrast enhancement. The lesion was biopsied, and histopathology revealed an intraosseous hibernoma composed of brown fat cells. Intraosseous hibernomas are rare and demonstrate non-specific imaging findings requiring biopsy for diagnosis, although most hibernomas are incidental and asymptomatic. Initial treatment with microwave ablation and cementoplasty improved the patient's symptoms temporarily but cementoplasty caused radicular symptoms, and eventually, cement removal, bone curettage, grafting and sacral nerve root decompression were required for symptom remission.

6.
J Oral Pathol Med ; 42(3): 201-7, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22672182

RESUMO

Kaposi sarcoma (KS), an AIDS defining condition, remains one of the most commonly HIV-associated neoplasms. While the use of highly active antiretroviral therapy (HAART) has brought about a dramatic decrease in the prevalence and incidence of AIDS-KS worldwide, this has not been the case in resource-poor sub-Saharan African countries, where HIV has reached epidemic proportions and human herpesvirus-8 infection is endemic. Oral involvement is a common manifestation of AIDS-associated KS and may be an early presenting finding of HIV infection. The clinical manifestation of oral KS can vary and may have an unpredictable course ranging from mild to fulminant. Rapidly progressive facial lymphoedema associated with extensive advanced oral KS portends a poor prognosis. Oral KS may regress with antiretroviral therapy or may flare up as part of the immune reconstitution inflammatory syndrome. The oral lesions of AIDS-KS are best managed with HAART together with systemic chemotherapy. This article provides a review of contemporary knowledge of the biology, pathology, clinical features and management of oral AIDS-KS.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/patologia , Neoplasias Bucais/patologia , Sarcoma de Kaposi/patologia , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Antirretrovirais/uso terapêutico , Terapia Antirretroviral de Alta Atividade , Infecções por HIV/patologia , Herpesvirus Humano 8/fisiologia , Humanos , Linfedema/patologia , Neoplasias Bucais/tratamento farmacológico , Sarcoma de Kaposi/tratamento farmacológico
8.
Clin Exp Dermatol ; 35(1): 68-72, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19874352

RESUMO

The importance of immunohistochemistry (IHC) to our understanding, ability to confidently diagnose and treat Kaposi's sarcoma (KS) has grown steadily in the past few decades. IHC has been performed on many KS specimen types, with > 100 different primary antibodies. Therefore, it is not surprising that IHC has helped unravel the histogenesis, understand the pathogenesis and facilitate the diagnosis of KS and identify novel therapeutic targets in the disease. This paper reviews the literature on the use of IHC in the study of KS.


Assuntos
Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologia , Pele/patologia , Anticorpos Antivirais/metabolismo , Antígenos Virais/metabolismo , Diferenciação Celular , Células Cultivadas , Humanos , Imuno-Histoquímica , Estadiamento de Neoplasias , Sarcoma de Kaposi/genética , Neoplasias Cutâneas/genética
11.
J Laryngol Otol ; 122(9): 993-7, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17524171

RESUMO

BACKGROUND: Oral involvement is a common manifestation of acquired immunodeficiency syndrome related Kaposi's sarcoma, and it occurs in approximately one-third of afflicted patients. METHODS: We report an unusual case of Kaposi's sarcoma of the hard palate which invaded the underlying maxillary bone. RESULTS: The patient underwent excisional biopsy and was subsequently treated with localised radiation and systemic chemotherapy including liposomal doxorubicin. CONCLUSIONS: The presentation, differential diagnosis, radiographic appearance and management of this serious complication are discussed. Our case highlights the need for a multidisciplinary approach, consisting of ENT, oncology and infectious disease consultation, to ensure appropriate management of maxillofacial, intraosseous, acquired immunodeficiency syndrome related Kaposi's sarcoma.


Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Maxila/patologia , Neoplasias Palatinas/patologia , Palato Duro/patologia , Sarcoma de Kaposi/patologia , Humanos , Masculino , Pessoa de Meia-Idade
15.
Transfus Med ; 12(2): 85-106, 2002 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11982962

RESUMO

Ticks are effective vectors of viral, bacterial, rickettsial and parasitic diseases. Many of the tick-borne diseases (TBDs) are of significance to transfusion medicine, either because of the risks they pose to the blood supply or the necessity for blood products required in their treatment. The transmission of tick-borne pathogens via blood transfusion is of global concern. However, among transfusion medicine practitioners, experience with most of these microorganisms is limited. Transfusion transmission of TBDs has been documented largely by means of single case reports. A better understanding of the epidemiology, biology and management of this group of diseases is necessary in order to assess the risks they pose to the blood supply and to help guide effective prevention strategies to reduce this risk. Unique methods are required to focus on donor selection, predonation questioning, mass screening and inactivation or eradication procedures. The role of the transfusion medicine service in their treatment also needs to be better defined. This article reviews the growing body of literature pertaining to this emerging field of transfusion medicine and offers some recommendations for transfusionists in dealing with TBDs.


Assuntos
Doenças Transmitidas por Carrapatos/microbiologia , Doenças Transmitidas por Carrapatos/transmissão , Reação Transfusional , Animais , Bancos de Sangue/normas , Doadores de Sangue , Humanos , Controle de Infecções/métodos , Controle de Infecções/normas , Infecções/diagnóstico , Infecções/microbiologia , Infecções/transmissão , Doenças Transmitidas por Carrapatos/epidemiologia
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