1.
Bioorg Med Chem Lett
; 20(17): 5089-94, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20674352
RESUMO
A series of acyloxyalkyl and amidooxyalkyl ketones appended to a carbobenzyloxy aspartic acid core have been prepared. The most potent of these new inhibitors was 4i with a K(i) of 0.5 microM. These two series provide an improved understanding of the binding requirements for the hydrophobic prime side of ICE.