[Development of an algorithm for the appointment of biofeed-back therapy and Cytoflavin for the treatment of osteochondrosis in elderly patients.]

Continuous improvement of protocols for the treatment of various ailments, in particular, osteochondrosis, is one of the important tasks of providing medical care to elderly patients. Supplementation of treatment with Cytoflavin and biofeed-back therapy seems to be a promising solution, however, it is necessary to develop an algorithm to predict it effectiveness in patients taking into account their initial clinical and psychophysiological status. As a result of the treatment, predictors of the effectiveness of the use of Cytoflavin and biofeed-back therapy have been identified and an algorithm for their administration has been developed.

[Biofeed back therapy and Cytoflavin in the system of medical support of the training process of elderly hockey players.]

One of the ways to improve the condition of the elderly body is the method of auto-training with biofeedback, as a means of correcting deviations in the functioning of the regulatory apparatus, as well as improving antioxidant protection and eliminating the effects of oxidative stress using Cytoflavin therapy. These methods seem to be a simple and effective means of correcting negative changes in the FS of elderly hockey players after a training cycle and ensuring the possibility of a more complete recovery of their body. The difference in the points of application made it possible to combine the intake of Cytoflavin and biofeedback training into a single complex correctional and restorative technique. Purpose of the research: to consider the organizational and methodological aspects of introducing a comprehensive methodology for correcting the functional state of elderly hockey players into the system of support of their training process. Based on the results of the study, we have obtained convincing data on the positive effect of the inclusion of Cytoflavin and biofeedback training in the system of medical support for the training process of elderly hockey players. The organizational and methodological aspects of introducing a comprehensive methodology for correcting the functional state of older hockey players into the system of support for their training process considered in this article make it possible to solve a number of problems facing medical workers regarding continuous monitoring of the functional state of older hockey players, proactive diagnosis of their negative deviations, as well as a system of reabilitation.

[Approaches to psychopharmacological correction of the functional state of elderly people in playing with game sports.]

The observed increase number of elderly actively employed persons. This indicates the need to study both classical geriatric aspects and new ways to maintain the proper level of their functional states. The current level of knowledge about the methods of adjusting functional states provides ample opportunity to correct violations in systems that are the most susceptible to factors of intense sports activity. According to the results of a comprehensive survey of a group of elderly ice hockey players, the most pronounced changes in the functioning of the central nervous system and antioxidant defense were determined. In this target group it is rationally to combine the use of the complex metabolic drug Cytoflavin with neurotropic antioxidant activity and the biological feedback method, as one of the most effective and safe ways to increase efficiency, having an extensive evidence base.

[Cytoflavin as a modulator of rehabilitation treatment of patients with ischemic stroke complicated by post-intensive care syndrome]. / Tsitoflavin kak komponent reabilitatsionnogo lecheniya patsientov s ishemicheskim insul'tom, oslozhnennym PIT-sindromom.

OBJECTIVE: To assess an effect of cytoflavin on the results of rehabilitation treatment and the increase in exercise tolerance in patients with stroke complicated by post-intensive care syndrome (PICS). MATERIAL AND METHODS: The data of 53 patients who underwent neurorehabilitation in the ICU after ischemic stroke were analyzed. Depending on the treatment regimen, the patients were divided into two groups. Group 1 (main, n=36) received cytoflavin (iv drip in a volume of 10 ml of a solution for injections per 200 ml of a 0.9% solution of sodium chloride) for 10 days in addition to the complex of neurorehabilitation measures. Group 2 (control, n=17) included patients, who had only a standard set of neurorehabilitation measures for 10 days. The efficacy of the therapy was evaluated using indirect calorimetry, and the oxygen and energy load price index was calculated. To assess the tolerability of rehabilitation methods, a verticalization test was used. Treatment tolerance was assessed by the incidence of adverse reactions in each group. RESULTS AND CONCLUSION: The components of the energytropic effect of cytoflavin can have a positive modulating effect, increasing the tolerance of rehabilitation measures for the treatment of PICS in patients with ischemic stroke. Further research is required.

[Study of the most significant for the correction components of the functional condition of elderly hockey players.]

Presents the results of a dynamic integrated study of the vegetative, metabolic and psycho-physiological components of the functional state of elderly hockey players before and after participating in competitions. The study involved 42 male hockey players aged 55-64 years. It has been established that the indicators of the vegetative regulation of cardiac activity are the most stable component of the functional state in the group of elderly athletes. At the same time, after participating in competitions, a statistically significant decrease in the simple sensorimotor response and an increase in lipid peroxidation processes were revealed. It is proved that the use of therapeutic regulators of the functional state (in particular, pharmaco-, psycho- and physiotherapeutic) should be directed to the components of the central nervous system and the antioxidant defense system, as the most sensitive and susceptible to suffering.

[SUBSTANTIATION OF INDICATIONS FOR BIOFEEDBACK THERAPY AND CYTOFLAVIN APPLICATION IN TREATMENT OF OSTEOCHONDROSIS NEUROLOGICAL COMPLICATIONS IN ELDERLY PATIENTS].

The aim of the study was to assess the impact of cytoflavin and bioflavin therapy on the dynamics of clinical and psychophysiological status of patients with Osteochondrosis. 150 patients with osteochondrosis of a backbone were investigated. The patients were divided into two groups using method of randomization: the main group - 75 patients - and control group -75 patients. All patients received a standard treatment (non-steroidal anti-inflammatory drugs, myorelaxants, chondroprotectors, as well as physiotherapy). The main group in addition to standard treatment received biofeedback therapy and cytoflavin. The results showed that cytoflavin and biofeedback therapy significantly enhanced the positive effect of standard treatment and significantly increased the quality of life of patients. It is recommended to treat elderly patients with neurological complications of spinal osteochondrosis with Cytoflavin in combination with biofeedback therapy Before prescribing biofeedback therapy and Cytoflavin it is necessary to take into account a number of positive and negative predictors of their effectiveness in reducing severity of pain syndrome.

[Evaluation of bio-inverse communication and Cytoflavin effects on the dynamics of the clinical and psychophysiological condition of elderly patients with osteochondrosis].

We conducted a study of 150 patients on the basis of polyclinic № 91 in St. Petersburg. The effect of Cytoflavin and bio-inverse communication therapy on the dynamics of the condition of elderly patients with osteochondrosis was evaluated. A number of positive effects from such an addition to existing therapy, potentiating the nominal effect, were revealed.

[Dynamics of indicators of the functional state of the central nervous system in Navy operators treated with cytoflavin after a long working cycle]. / Dinamika pokazatelei funktsional'nogo sostoianiia tsentral'noi nervnoi sistemy u operatorov Voenno-morskogo flota posle dlitel'nogo rabochego tsikla na fone priema tsitoflavina.

AIM: To evaluate the efficacy of cytoflavin in the correction of functional state and working ability of Navy operators after a long working cycle. MATERIAL AND METHODS: Results of the examination of 25 Navy operators, aged from 27 to 42 years, were analyzed at baseline and after treatment with cytoflavin. The Rusalov questionnaire for Individuality Formal Dynamic Properties and EEG were used to evaluate the state of participants. RESULTS AND CONCLUSION: The results demonstrate the ability of cytoflavin to exert the positive effect on the energetic component of the functional state of Navy operators after a long working cycle, increasing the psychomotor activity and optimizing the spontaneous electrical activity of the brain. The activation of energetic potential, physical activity and emotional reactions by cytoflavin is correlated with the growth of the central nervous system reserves in Navy operators treated after a long working cycle.

[Peculiarities of clinical and psychophysiological status of elderly patients with osteochondrosis.]

We conducted a study of 220 patients in polyclinic № 91 in St. Petersburg. It was revealed that elderly patients with osteochondrosis are characterized by a high prevalence and severity of osteochondrosis against the background of metabolic disorders in the structures of the spine. At the same time, the actual condition of the spine does not always determine the severity of the pain syndrome. The effect of osteochondrosis on the development of comorbid pathology has been clarified. The ways of correction of the clinical and psychophysiological status of elderly patients with osteochondrosis such as appointment of Cytoflavin, behavioral therapy and biofeed back therapy are suggested.

[The influence of cytoflavin on the recovery of cognitive function in elderly people with alcohol abuse]. / Vliyanie tsitoflavina na vosstanovlenie kognitivnykh funktsii u stradayushchikh alkogolizmom pozhilykh lits.

AIM: To assess effects and to study an influence of cytoflavin on the changes of cognitive functions in the complex treatment of elderly patients with alcoholism. MATERIAL AND METHODS: A prospective cohort randomized parallel study was carried out in the group of 74 elderly patients with alcoholism. RESULTS AND CONCLUSION: Significant positive changes (p<0.05) in the clinical/neurological status of patients was observed during the optimized and combined treatment with the inclusion of cytoflavin in the treatment scheme. There was a rapid and marked improvement in the indices of neuropsychological tests compared to the patients of the comparison group.

[Application of immunomodulators in the treatment of mandibular fractures in elderly patients with incomplete secondary adentia].

The aim of the work was to study the experience of using complex pharmacotherapy in the treatment of mandibular fractures in elderly patients with incomplete secondary periodontitis, which were divided into two groups. In the first group, patients (n = 46; average age 69.0 ± 3.6) were treated using the authors' original device combined with application of antimicrobial MetrogilDenta gel onto gums two times a day during ten days. Patients in the second group (n = 52; average age 61.0 ± 3.1) were treated with the same device combined with (i) application of MetrogilDenta antimicrobial gel onto gums two times a day during ten days, (ii) application of 1.5 ml of Cycloferon 5% liniment by cotton pellet for 20 min during the same 10 days (30 minutes after the antimicrobial gel), and (iii) intramuscular injections of 6 mg of synthetic immunomodulator Polyoxidonium once a day for 3 days, then once every two days (for a total of 17 days). It is established that the use of the combination of interferon inducers of immunomodulator group--Cycloferon in the form of liniment and synthetic immunomodulator Polyoksidonium together with MetrogilDenta antimicrobial gel--led to the most pronounced regression of inflammatory and destructive processes in periodontal tissues (in 7.1%, d = 0.05), optimized the state of local immunity of the oral cavity, and normalized microflora in periodontal pockets in elderly patients with incomplete secondary adentia.

[Use of metabolic drugs and psychotherapy in dental implantation in elderly patients].

The estimation of efficiency of metabolic drugs and psychotherapy in dental implantation in the elderly was carried out. On the basis of the study results an important pathogenetic significance of use of metabolic drug cytoflavin and cognitive therapy in the treatment of partially adentia at elderly patients was justified. It was proved that the optimization of the internal picture of health by means of the implementation of information and regulatory functions, and emotional reinforcement of the therapeutic process in patients receiving cytoflavin and cognitive therapy would improve the effectiveness of the treatment, to increase "survival" performance of implants and to approach to understanding the underlying mechanisms of forming health in elderly patients with partial adentia.

[Therapy of chronic apical periodontitis in the elderly age].

The article is devoted to the actual problem in modern medicine therapy of chronic apical periodontitis in the elderly age. It is shown that periodontitis remains till today the leading cause of tooth extraction in the elderly age; in addition, periodontitis can lead to serious complications such as periostitis, phlegmon, osteomyelitis, which creates additional scientific interest in the study of the above complications at the junction of the two specialties--gerontology and stomatology. In elderly patients regeneration after the periodontal infectious processes takes more time, in this case the traditional approach to treatment of inflammation in the periodontium shows frequent lack of regression of the focus of periapical destruction. Based on the results of the study it is proved that prolonged antiseptic and immune-stimulating effect of therapeutic paste PED used in conjunction with 5% liniment cycloferon, leads to a rapid and marked reduction in inflammatory activity in the affected area both at granulating, and at granulomatous forms of chronic periodontitis, and is accompanied by a significantly larger share of the achieved remission.

[The clinico-epidemiological characteristics of opisthorchiasis foci in the Yamalo-Nenets Autonomous Okrug and the treatment results with praziquantel]. / Kliniko-épidemiologicheskaia kharakteristika ochagov opistorkhoza v Iamalo-Nenetskom avtonomnom okruge i rezul'taty lecheniia prazikvantelem.

A clinical and epidemiological study of opisthorchiasis foci in the Yamalo-Nenets Autonomous Okrug was carried out. 764 people were surveyed, including 473 aborigines of the north, 207 denizens, and 84 migrants. Opisthorchiasis infection rate in villages was 40.5-45.7%. The intensity of infection was lower than 200 eggs per g faeces. The modelling of opisthorchiasis prevalence performed after Muench showed the highest correlation with the "simple" and "reversible" models. Factors determining the infection spread and limiting its intensity and those influencing the effect of chemotherapy were defined. Theoretically determined radical suppressive low-dose praziquantel chemotherapy was carried out. The efficacy of the drug, 25, 30, 40 and 50 mg/kg, varied from 76.5 to 92.0% (mean 88.1%), and the decrease of the egg density was more than 60%. The incidence of side effects of the therapy averaged 45.3%.

[The comparative characteristics of the clinico-immunological indices in different contingents of opisthorchiasis patients in a hyperendemic focus. 4. The transplacental transmission of Opisthorchis felineus antigens]. / Sravnitel'naia kharakteristika kliniko-immunologicheskikh pokazatelei raznykh kontingentov bol'nykh opistorkhozom v giperéndemichnom ochage. Soobshchenie 4. Transplatsentarnaia peredacha antigenov Opisthorchis felineus.

25 women in labour with chronic opisthorchiasis have been examined. They were representatives of native (7), local (8) and migrated population of the focus. Control group comprised 10 women from the local population free of invasion. Their immune status was assessed by the level of IgA, IgG, IgM, circulating immune complexes (CIC) and specific antibodies in the serum obtained from peripheral and funic veins, as determined by enzyme immunoassay (ELISA). To detect opisthorchis antigens in the serum modified radial immunodiffusion test was used. Antibody titres in ELISA, IgG and CIC levels were the highest in migrated women. Antibody titres in ELISA and IgG level in the newborn of migrated women were also considerably higher than in other newborn. Serum IgM level in all groups of newborn was considerably lower than in their mothers and IgA was altogether undetectable. In 3 native and 2 local women the results of immunodiffusion test were positive. It is suggested that transplacental migration of opisthorchis throughout the neonatal period may lead to tolerance formation.

[Clinico-immunologic indices of various patient contingents in a focus of chronic opisthorchiasis. 3. Dynamics of the indices following praziquantel treatment]. / Kliniko-immunologicheskie pokazateli u raznykh kontingentov bol'nykh khronicheskim opistorkhozom v ochage. Soobshchenie 3. Dinamika pokazatelei posle lecheniia prazikvantelem.

Studies of the time course of the immune status characteristics after praziquantel treatment and of the nature of its side-effects on various groups of opisthorchiasis patients in the focus established significant differences in their immune response to specific treatment. The lack of alterations in the T- and B-immunity systems in aboriginal population of the focus may suggest its tolerance to helminthic antigens. The trend towards cellular immunity stimulation and a significant increase in the levels of circulating immune complexes and specific antibodies in the serum were observed in aboriginal population of the focus. The comers showed significant initial alterations of the immunity status before treatment, pointing to their sensitization to parasitic antigens. Suppression of the infection normalizes several cellular and humoral immunity characteristics--the number of T-helpers, T-lymphocytes, B-lymphocytes, Th/Tc indices, T-lymphocyte functional activity, thus eliminating immune depression. The increased IgG, CIC and specific antibody levels significantly exceeding the normal level, occurrence or enhancement of allergic reactions point to the necessity of performing a desensitizing therapy and using effective cholagogic drugs in the multimodality treatment to rapidly eliminate the parasitic antigen.

[Comparative characteristics of clinical and immunologic indicators of various groups of opisthorchiasis patients in a focus. Aboriginal population]. / Sravnitel'naia kharakteristika kliniko-immunologicheskikh pokazatelei raznykh kontingentov bol'nykh opistorkhozom v ochage. Korennoe naselenie.

Clinical and immunological observations of people belonging to two population groups--aborigens (khanty, mansi, komi) and 40 immigrants--were performed in opisthorchiasis foci of the Tyumen region. Rapid clinical reinvasion of unimmune immigrants (in a 3-4 year period) was established; the aborigens featured subclinical invasion pattern. T-system immunity in immigrants was suppressed, while in the aboriginal group insignificant reduction of the number of T-helpers and significant increase in the number of T-suppressors, lack of apparent mobilization of humoral immunity factors--reduction of the absolute B-lymphocytes number, normal A, G immunoglobulines and CIC levels-were observed. Such T--B immune systems' ratio may indicate immune tolerance of a suppressor type. The observed indicators of aborigens' tolerance to helminths' antigens point to the necessity of differentiated approach to chemotherapy prescription (especially of the repeated courses) in the endemic invasion foci.