RESUMO
PURPOSE: This study was undertaken to evaluate the clinical and microbiological effects of an erythritol powder air-polishing device (EPAP) as a supplement to scaling and root planing (SRP) therapy in patients with moderate chronic periodontitis. METHODS: Clinical and microbiological evaluations were performed at 21 sites treated with SRP (control) and 21 sites treated with SRP+EPAP (test). All examinations were performed before treatment, 1 month after treatment, and 3 months after treatment. RESULTS: There were no significant clinical differences between the test group and the control group. Microbiological analysis revealed that the relative expression level of Porphyromonas gingivalis was significantly lower in the test group than in the control group at 1 month after treatment. Clinical and microbiological results showed improvements at 1 month compared to baseline; in contrast, the results at 3 months after treatment were worse than those at 1 month after treatment. CONCLUSIONS: In this study, both SRP and SRP+EPAP were clinically and microbiologically effective as non-surgical periodontal treatments. In particular, the SRP+EPAP group showed an antimicrobial effect on P. gingivalis, a keystone bacterium associated with the onset of chronic periodontitis, in a short-term period. Periodic periodontal therapy, at intervals of at least every 3 months, is important for sustaining the microbiological effects of this treatment.
RESUMO
A palladium-catalyzed ortho-acylation of N-benzyltriflamides from the alcohol oxidation level via C-H bond activation is described. These transformations have been applied to a wide range of substrates, and typically proceed with excellent levels of chemoselectivity and with high functional group tolerance.
Assuntos
Álcoois/química , Amidas/química , Cetonas/síntese química , Catálise , Cetonas/química , Estrutura Molecular , Oxirredução , Paládio/químicaRESUMO
A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives.
Assuntos
Acetamidas/química , Ácidos Carboxílicos/química , Cromonas/síntese química , Compostos Organometálicos/química , Paládio/química , Acilação , Catálise , Cromonas/química , Descarboxilação , Estrutura MolecularRESUMO
A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range of O-methyl ketoximes and α-keto acids undergoes the decarboxylative cross-coupling reactions with high selectivities and good tolerance.
Assuntos
Cetoácidos/química , Oximas/química , Paládio/química , Acilação , CatáliseRESUMO
The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of ß-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC(50) values of 18.3 and 17.9 µM, respectively.
Assuntos
Complexo Antígeno-Anticorpo/imunologia , Degranulação Celular/efeitos dos fármacos , Lignanas/química , Animais , Basófilos/fisiologia , Linhagem Celular Tumoral , Imunoglobulina E/química , Imunoglobulina E/metabolismo , Lignanas/síntese química , Lignanas/farmacologia , Ratos , Relação Estrutura-Atividade , beta-N-Acetil-Hexosaminidases/metabolismoRESUMO
The rhodium-catalyzed oxidative acylation between secondary benzamides and aryl aldehydes via sp(2) C-H bond activation followed by an intramolecular cyclization is described. This method results in the direct and efficient synthesis of 3-hydroxyisoindolin-1-one building blocks.
Assuntos
Aldeídos/química , Benzamidas/química , Indóis/síntese química , Ródio/química , Acilação , Catálise , Ciclização , Hidroxilação , Estrutura Molecular , Oxirredução , EstereoisomerismoRESUMO
A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp(2) C-H bond cleavage is described. In the presence of [Cp*RhCl(2)](2), AgSbF(6), and silver carbonate as an oxidant, N,N-diethyl benzamides can be effectively carbonylated to yield ortho-acyl benzamides.
Assuntos
Aldeídos/química , Benzamidas/química , Carbono/química , Hidrogênio/química , Ródio/química , Acilação , Catálise , Estrutura Molecular , OxirreduçãoRESUMO
One-pot synthesis of symmetric 1,4-disubstituted 1,3-diynes from iodoarenes and propiolic acid via Sonogashira reaction followed by Pd-catalyzed decarboxylative homocoupling is developed in high yields. Also, this system allows the one-pot synthesis of unsymmetric 1,4-disubstituted 1,3-diynes by cross-coupling of two different 3-substituted propiolic acids.