[New data on the development of complications during epidemiological parotitis in children]. / Novoe v patogeneze razvitiia oslozhnenii pri épidemicheskom parotite u detei.

The main factors in the pathogenesis of complicated parotitis virus infection are increased virus reproduction in the salivary gland, inhibited by the production of alpha-interferon at early stages of the infectious process. Entry of the virus into the CNS is caused by slight penetration of antiparotitis antibodies through the blood-brain barrier and by poor formation of specific immune complexes at the site of primary virus reproduction and in the liquor. Interferon therapy of patients with parotitis virus infection corrects the chain of processes in the pathogenesis. In parotitic meningitis neovir stimulates gamma-interferon, which blocks the synthesis of parotitis antigen in the cell and stimulates (through antibody stimulation) the formation of specific immune complexes released with the saliva in the gland. Viferon is more active in parotitic orchitis due to prolongation of alpha-interferon activity.

[The use of a modified complement fixation reaction for the rapid diagnosis of viral infections in children]. / Ispol'zovanie modifitsrovannoi reaktsii sviazyvaniia komplementa dlia ékspresssnoi diagnostiki virusnykh infektsii u detei.

A system of diagnostic tests (complement enzyme assay) is developed, detecting viral and other antigens, toxins, antibodies, and specific immune complexes in liquid enzyme immunoassay based on the complement fixation test. The system is simple and economic, the results can be transferred into digital data, and the above factors can be detected individually in biological materials from patients. The system is effective, and in many cases (for example, in the diagnosis of enteroviral diseases) is the only method for rapid isolation and typing of the infection agents.